Podcast
Questions and Answers
What is the dosage range for Apixaban (Eliquis)?
What is the dosage range for Apixaban (Eliquis)?
- 5-10 mg/BID
- 10-15 mg/BID
- 1-2 mg/BID
- 2.5-5 mg/BID (correct)
What class of medication is Apixaban (Eliquis)?
What class of medication is Apixaban (Eliquis)?
Anti-coagulant
How does Apixaban (Eliquis) work?
How does Apixaban (Eliquis) work?
Acts as a selective site inhibitor of factor Xa inhibiting both free and bound factor, decreasing thrombin generation and development.
What is the peak time for Apixaban (Eliquis)?
What is the peak time for Apixaban (Eliquis)?
What is the duration of action for Apixaban (Eliquis)?
What is the duration of action for Apixaban (Eliquis)?
What are common adverse reactions to Apixaban (Eliquis)?
What are common adverse reactions to Apixaban (Eliquis)?
Which of the following are side effects of Apixaban (Eliquis)?
Which of the following are side effects of Apixaban (Eliquis)?
Before surgery, Apixaban (Eliquis) should be stopped ____ hours.
Before surgery, Apixaban (Eliquis) should be stopped ____ hours.
What should patients report when taking Apixaban (Eliquis)?
What should patients report when taking Apixaban (Eliquis)?
What should be avoided when taking Apixaban (Eliquis)?
What should be avoided when taking Apixaban (Eliquis)?
What are some nursing considerations when administering Apixaban (Eliquis)?
What are some nursing considerations when administering Apixaban (Eliquis)?
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Study Notes
Apixaban (Eliquis) Overview
- Dosage ranges from 2.5-5 mg taken twice daily (BID).
- Classified as an anti-coagulant, it helps prevent blood clots.
Mechanism of Action
- Selectively inhibits factor Xa, impacting both free and bound forms.
- Reduces thrombin generation, thereby decreasing clot development.
Pharmacokinetics
- Peak plasma concentration occurs within 3-4 hours after administration.
- Duration of action lasts approximately 24 hours, supporting once or twice-daily dosing.
Adverse Reactions
- Major concern includes bleeding, which can pose serious risks to patients.
- Other potential side effects include anaphylaxis, a severe allergic reaction.
Nursing Considerations
- Monitor patients for signs of bleeding, including gastrointestinal (GI), genitourinary (GU), and visible bruising.
- Evaluate for symptoms indicating conditions such as stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), or peripheral vascular disease.
- Discontinue medication 24 hours prior to any surgical procedures to minimize bleeding risk.
Patient Education
- Instruct patients to promptly report any appearance of pink or red urine.
- Advise reporting black or red stools, which may indicate gastrointestinal bleeding.
- Recommend avoiding nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin (ASA) to reduce bleeding risk.
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