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Questions and Answers
What is the therapeutic class of Apixaban (Eliquis)?
What is the therapeutic class of Apixaban (Eliquis)?
What is the pharmacologic classification of Apixaban (Eliquis)?
What is the pharmacologic classification of Apixaban (Eliquis)?
Factor Xa Inhibitor
What are the primary actions and uses of Apixaban (Eliquis)?
What are the primary actions and uses of Apixaban (Eliquis)?
Prevent and treat DVT, reduce risk of clots and strokes in a.Fib patients, blocks factor Xa.
Which of the following are adverse reactions of Apixaban (Eliquis)?
Which of the following are adverse reactions of Apixaban (Eliquis)?
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Which substances may interact with Apixaban (Eliquis)?
Which substances may interact with Apixaban (Eliquis)?
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What are some nurse responsibilities when administering Apixaban (Eliquis)?
What are some nurse responsibilities when administering Apixaban (Eliquis)?
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Patients on Apixaban (Eliquis) need to regularly monitor their INR levels.
Patients on Apixaban (Eliquis) need to regularly monitor their INR levels.
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What are some important teachings for patients taking Apixaban (Eliquis)?
What are some important teachings for patients taking Apixaban (Eliquis)?
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What are some contraindications for taking Apixaban (Eliquis)?
What are some contraindications for taking Apixaban (Eliquis)?
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What is the black box warning (BBW) for Apixaban (Eliquis)?
What is the black box warning (BBW) for Apixaban (Eliquis)?
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Study Notes
Apixaban (Eliquis) Overview
- Classified as an anticoagulant, Apixaban is primarily used to prevent and treat deep vein thrombosis (DVT).
- Acts as a Factor Xa Inhibitor, disrupting the coagulation cascade to prevent clot formation.
Actions and Uses
- Prevents and treats DVT; crucial in reducing the risk of clots and strokes in patients with atrial fibrillation (a.Fib).
- Blocks Factor Xa, an essential clotting factor in the coagulation pathway.
Adverse Reactions
- Common adverse effects include bleeding, which can lead to anemia and hematoma formation.
- Other potential reactions are thrombocytopenia (low platelet count) and syncope (fainting).
Drug Interactions
- Interacts with drugs metabolized by CYP3A4, including several oral anticoagulants and antiplatelet drugs.
- Caution with concurrent use of antidepressants, antifungals, and seizure medications, as these may increase bleeding risk or alter drug effectiveness.
Nurse Responsibilities
- Screen for history of bleeding disorders, assess complete blood count (CBC), and review medical history.
- Monitor patient adherence to medication regimens as well as heart rate and blood pressure.
Patient Teaching
- There is no available antidote for Apixaban, emphasizing the importance of understanding its long-term use.
- Patients should not abruptly discontinue the medication to reduce the risk of serious blood clot formation.
- Apixaban can be crushed for easier administration and is typically taken twice daily, every 12 hours; INR testing is unnecessary.
Contraindications
- Contraindicated during pregnancy, in patients older than 80 years, and with spinal epidurals due to increased bleeding risk.
- Exercise caution in individuals with blood disorders and when dealing with sharp instruments.
Black Box Warning (BBW)
- Stopping Apixaban increases the risk of developing serious blood clots.
- Patients undergoing anesthesia with a spinal column should not take Apixaban to avoid heightened bleeding risks.
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Test your knowledge on Apixaban (Eliquis) with these flashcards. Learn about its therapeutic class, pharmacologic actions, adverse reactions, and drug interactions. Ideal for pharmacy students and healthcare professionals.
