Apixaban and Anti-Blood Clotting Mechanism Quiz

Apixaban primarily impacts the coagulation cascade by inhibiting specific clotting factors, while aspirin targets platelet function and aggregation via COX enzymes.

Combining apixaban with drugs that inhibit CYP3A4 or P-glycoprotein can lead to higher apixaban levels in the body, slowing down the breakdown of apixaban and prolonging its anticoagulant action, potentially increasing the risk of bleeding.

Apixaban works as a directly acting anticoagulant, making it easier for the blood to flow through the body and preventing blood clots.

<p>A common side effect associated with the mechanism of action of apixaban is an increased risk of bleeding or hemorrhage.</p> Signup and view all the answers

<p>P-glycoprotein is a protein that helps remove substances, including medications, from cells. Apixaban is a substrate for P-glycoprotein, meaning it is pumped out of cells by this protein. Combining with drugs that inhibit P-glycoprotein can prolong the anticoagulant action of apixaban.</p> Signup and view all the answers

<p>Antagonist of the AT1 receptor, leading to vasodilation and reduced aldosterone production, resulting in lower blood pressure.</p> Signup and view all the answers

<p>Hypertension and heart failure.</p> Signup and view all the answers

<p>Orthostatic hypotension and reduced capability for peripheral vasoconstriction, leading to lower blood pressure.</p> Signup and view all the answers

<p>ACE inhibitors inhibit the formation of angiotensin II, while ARBs inhibit the actions of angiotensin II mediated via the AT1 receptor. ACE inhibitors have a wider range of actions.</p> Signup and view all the answers

<p>By reducing aldosterone production, lowering sodium re-uptake in the kidney, and leading to vasodilation.</p> Signup and view all the answers