20 Questions
Which class of drugs slows down the protein synthesis and transcription of viral mRNA in an infected cell?
Interferon
What is the main target of protease inhibitors like Boceprevir and telaprevir?
Viral-specific posttranslational modifications
Which enzyme of influenza viruses is crucial in preventing intracellular and cell surface aggregation of viral glycoproteins?
Neuraminidase
What is the primary mechanism of action of lamivudine and adefovir in inhibiting viral replication?
Slowing down protein synthesis and transcription of viral mRNA
Which drug class targets specific posttranslational modifications of viral proteins?
Protease inhibitors
Which of the following drugs is a guanosine analog that causes premature DNA chain termination?
Acyclovir
How do amantadine and rimantadine inhibit viral replication?
By blocking the hydrogen channel formed by the viral M2 proton pore
Which drug is effective against many RNA viruses, including respiratory syncytial virus infections in infants?
Ribavirin
What is the mechanism of action of ribavirin in inhibiting viral replication?
Inhibiting GTP formation
Which of the following drugs is converted into di- and triphosphate forms by host cell kinases to cause premature DNA chain termination?
Valacyclovir
What is the mechanism of action of ribavirin 5`-phosphate derivatives?
Inhibit viral RNA polymerase
Which type of viruses can be targeted by reverse transcriptase inhibitors?
Retroviruses
What is the role of Remdesivir as an antiviral agent?
Inhibits viral RNA polymerase
Why are reverse transcriptase inhibitors phosphorylated to the active form by host kinases?
To inhibit viral reverse transcriptase
When is Remdesivir currently approved as a COVID-19 treatment?
Within 5 days of symptoms
What is the first step in the viral life cycle?
Viral attachment to the cell
Which type of antibodies bind to the viral attachment protein to prevent viral entry into cells?
Neutralizing antibodies
What is a common mechanism of inhibitors that target viral uncoating?
Interfering with disassembly of capsid
Which type of antiviral therapy involves the administration of specific antibodies?
Immunotherapy
For viruses that enter through endocytic vesicles, which process can be disrupted by inhibitors of viral uncoating?
Interaction with fusion protein
Test your knowledge on antiviral medications mechanisms such as how amantadine and rimantadine block the viral M2 proton pore and how nucleoside analogs like acyclovir inhibit viral replication. Identify how these medications interfere with the viral life cycle.
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