Antiviral Drugs for HIV Infection
18 Questions
10 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following describes the role of Interferons in the immune response against viral infections?

  • Interferons directly kill virus-infected cells.
  • Interferons inhibit cell division to prevent virus spread.
  • Interferons only stimulate B cells to produce antibodies.
  • Interferons activate signaling pathways leading to the production of cytokines. (correct)

    • What is the primary action of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in HIV treatment?

  • They inhibit the enzyme HIV protease.
  • They enhance the immune response to HIV.
  • They promote the integration of viral DNA into the host genome.
  • They block the reverse transcription of viral RNA into DNA. (correct)

    • What occurs after the recruitment of STAT proteins in the interferon signaling process?

  • Inhibition of viral replication.
  • Formation of new viral particles.
  • Increased production of antibodies.
  • Phosphorylation of STAT proteins. (correct)

    • Which type of antiviral drug does not directly inhibit reverse transcriptase activity?

    <p>Interferons</p> Signup and view all the answers

    What is the significance of interferons binding to specific cell surface receptors?

    <p>It triggers a cascade of cellular responses including the transcription of interferon-stimulated genes.</p> Signup and view all the answers

    Which of the following actions are associated with interferons?

    <p>Inhibit viral mRNA synthesis</p> Signup and view all the answers

    What is the role of 2',5'-Oligoadenylate synthetase (OAS) in the antiviral response?

    <p>Activates protein kinase R (PKR)</p> Signup and view all the answers

    Which adverse effect is NOT commonly associated with interferon therapy?

    <p>Elevated blood pressure</p> Signup and view all the answers

    What is the mechanism of action for NRTIs in treating HIV?

    <p>Inhibit viral reverse transcriptase</p> Signup and view all the answers

    Which of the following drugs is categorized as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)?

    <p>Nevirapine</p> Signup and view all the answers

    What is a significant side effect of Zidovudine therapy?

    <p>Neutropenia</p> Signup and view all the answers

    What distinguishes Non-Nucleoside Reverse Transcriptase Inhibitors from NRTIs?

    <p>Bind directly to the viral RT catalytic site</p> Signup and view all the answers

    Which statement accurately describes the effects of Tenofovir?

    <p>It is effective against HIV-1 and HIV-2</p> Signup and view all the answers

    What is one of the primary actions of protease inhibitors in HIV treatment?

    <p>Inhibit the cleavage of viral polyproteins</p> Signup and view all the answers

    Which condition is NOT typically treated with IFN-α-2b?

    <p>Acute bacterial infections</p> Signup and view all the answers

    Which class of anti-HIV drugs is known for requiring activation into triphosphate metabolites?

    <p>Nucleoside Reverse Transcriptase Inhibitors</p> Signup and view all the answers

    Which condition is associated with the adverse effect of lactic acidosis in anti-HIV drug therapy?

    <p>Use of NRTIs</p> Signup and view all the answers

    What is a major concern regarding resistance in NNRTIs for HIV therapy?

    <p>Resistance can occur due to mutations in reverse transcriptase</p> Signup and view all the answers

    Study Notes

    Antiviral Drugs – For HIV infection

    • Interferons are signaling proteins produced by host cells in response to pathogens.
    • Interferons bind to specific cell surface receptors and affect viral replication.
    • Antiviral drugs for HIV infection fall into several categories: NRTIs, NNRTIs, NtRTIs, Protease inhibitors, Entry/fusion inhibitors, CCR5 inhibitors, Integrase inhibitors, and Newer antiviral drugs.
    • NRTIs are activated into triphosphate metabolites by host cell kinase.
    • The triphosphate form of NRTIs competes with viral nucleoside triphosphate for viral RT.
    • NRTIs lack a 3’OH group or have –N3 in place of 3’ OH, which terminates DNA chain elongation.
    • Zidovudine is a thymidine analogue used for palliative treatment for HIV 1, 2 and HTLV I and II.
    • NNRTIs do not require activation through phosphorylation, binding directly to the catalytic site of viral RT and inactivating the enzyme to inhibit viral DNA synthesis.
    • Tenofovir, a nucleotide reverse transcriptase inhibitor (NtRTI), competitively inhibits HIV- RT enzyme.
    • Tenofovir is a prodrug hydrolysed in the liver to tenofovir and then phosphorylated to active tenofovir diphosphate.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Antiviral HIV Drugs PDF

    Description

    This quiz covers the various categories of antiviral drugs used in the treatment of HIV infection, including NRTIs, NNRTIs, and protease inhibitors. It also explains the mechanisms of action of interferons and how these drugs impact viral replication and DNA synthesis. Test your knowledge on HIV antiviral therapy!

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser