38 Questions
Which of the following is NOT a characteristic of an ideal antiviral drug?
Toxic
Which of the following is a target of anti-influenza drugs?
RNA polymerase
What is the primary goal of therapy and prophylaxis with antiviral drugs during a pandemic?
Reduce the number of deaths
Why is it more complex to employ drugs against viruses compared to bacteria?
Viruses can replicate exclusively in host cells
Which of the following is NOT a neuraminidase inhibitor?
Amantadine
Which drug is used to treat herpes simplex virus and chicken-pox virus?
Penciclovir
What is the mechanism of action of neuraminidase inhibitors?
They block the activity of neuraminidase
What is the goal of HIV treatment?
Reduce HIV-associated morbidity and prolong the duration and quality of survival
What is the role of thymidine kinase in the phosphorylation of CMV?
Thymidine kinase is absent in CMV
What makes retroviruses hard to eradicate?
Integration of their DNA into the host cell's genome is an essential step in the viral replication cycle
What is the mechanism of action of nucleos(t)ide reverse transcriptase inhibitors?
They arrest the synthesis of viral DNA by reverse transcriptase
Which type of drugs can suppress the synthesis of viral genome and viral particles production in HBV?
Acyclic nucleoside phosphonate analogues
What is the difference between HBV and HCV in terms of curability?
HCV is curable, while HBV is not curable
What is the mechanism of action of Ribavirin against viral replication?
It inhibits the production of viral nucleic acids
What is the advantage of using Interferon for treating viral infections?
It has low toxicity and modest antigenic properties
What is the mechanism of action of NTRIs in the treatment of HIV?
They lack a 3' hydroxyl group preventing further nucleotide attachment to viral DNA
What is the target of nonnucleoside reverse-transcriptase inhibitors (NNRTIs) in the treatment of HIV?
Reverse transcriptase
How do integrase inhibitors interfere with the replication of HIV?
They prevent the integration of viral DNA into the host chromosome by binding to integrase
What is the mechanism of action of protease inhibitors in the treatment of HIV?
They inhibit the activity of the HIV protease enzyme
Which enzyme is responsible for the first round of phosphorylation in CMV?
Viral kinase encoded by UL97 gene
What is the primary goal of antiretroviral therapy for HIV?
Reduce HIV-associated morbidity and prolong survival
What is the mechanism of action of nucleoside analogues and nucleotide analogues in the treatment of HIV?
Arrest the synthesis of viral DNA by reverse transcriptase
Which of the following drugs binds to gp120 to inhibit HIV-1 entry?
Fostemsavir
Which of the following is a nucleoside RT inhibitor used in the treatment of HBV?
Adefovir
What is the mechanism of action of Ribavirin against viral replication?
Inhibition of inosine monophosphate deidrogenase enzyme
Which of the following is NOT a characteristic of HBV infection?
Curable
What is the difference between HCV and HBV in terms of replication?
HCV replication occurs only in the cytoplasm
Which of the following human infectious diseases does NOT have drugs for treatment currently available?
Ebola virus infections
What are the characteristics of an ideal antiviral drug according to the text?
Water-soluble, chemically and metabolically stable, easily absorbed (apolar), carcinogenic
What is the primary goal of therapy and prophylaxis with antiviral drugs during a pandemic according to the text?
To reduce the number of individuals at risk of getting a disease (morbidity)
What is the primary target of neuraminidase inhibitors in the treatment of influenza?
The neuraminidase enzyme
Which of the following drugs is used to treat cytomegalovirus infections in patients with AIDS?
Ganciclovir
What is the mechanism of action of amantadine and rimantadine in the treatment of influenza?
Blocking the M2 viral proton pump
What is the primary advantage of acyclovir over guanosine in the treatment of herpes infections?
Lower concentration necessary to inhibit viral DNA polymerase
What is the mechanism of action of nonnucleoside reverse-transcriptase inhibitors (NNRTIs) in the treatment of HIV?
NNRTIs inhibit the activity of reverse transcriptase by binding to a hydrophobic pocket.
What is the mode of action of integrase inhibitors in the treatment of HIV?
Integrase inhibitors interfere with the strand transfer process of the viral DNA by competitively binding to the active site of integrase.
What is the target of protease inhibitors in the treatment of HIV?
Protease inhibitors inhibit the catalytic activity of HIV protease.
What is the new long-acting injection treatment option for HIV?
Cabotegravir and rilpivirine given as two separate injections every two months
"Test your knowledge on CMV and HIV treatment goals" - This quiz will assess your understanding of the first round of phosphorylation in CMV, the absence of thymidine kinase, and the role of UL97. It will also test your knowledge of the key treatment goals of HIV, including the maximization and preservation of immunological function.
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