CMV and HIV Treatment Goals Quiz
38 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following is NOT a characteristic of an ideal antiviral drug?

  • Chemically and metabolically stable
  • Easily absorbed (apolar)
  • Water-soluble
  • Toxic (correct)

    • Which of the following is a target of anti-influenza drugs?

  • DNA polymerase
  • RNA polymerase (correct)
  • Reverse transcriptase
  • Protein kinase

    • What is the primary goal of therapy and prophylaxis with antiviral drugs during a pandemic?

  • Spread new virus subtypes
  • Protect people who play key roles in managing the response to pandemic
  • Reduce the number of deaths (correct)
  • Increase the number of individuals at risk of getting a disease

    • Why is it more complex to employ drugs against viruses compared to bacteria?

    <p>Viruses can replicate exclusively in host cells</p> Signup and view all the answers

    Which of the following is NOT a neuraminidase inhibitor?

    <p>Amantadine</p> Signup and view all the answers

    Which drug is used to treat herpes simplex virus and chicken-pox virus?

    <p>Penciclovir</p> Signup and view all the answers

    What is the mechanism of action of neuraminidase inhibitors?

    <p>They block the activity of neuraminidase</p> Signup and view all the answers

    What is the goal of HIV treatment?

    <p>Reduce HIV-associated morbidity and prolong the duration and quality of survival</p> Signup and view all the answers

    What is the role of thymidine kinase in the phosphorylation of CMV?

    <p>Thymidine kinase is absent in CMV</p> Signup and view all the answers

    What makes retroviruses hard to eradicate?

    <p>Integration of their DNA into the host cell's genome is an essential step in the viral replication cycle</p> Signup and view all the answers

    What is the mechanism of action of nucleos(t)ide reverse transcriptase inhibitors?

    <p>They arrest the synthesis of viral DNA by reverse transcriptase</p> Signup and view all the answers

    Which type of drugs can suppress the synthesis of viral genome and viral particles production in HBV?

    <p>Acyclic nucleoside phosphonate analogues</p> Signup and view all the answers

    What is the difference between HBV and HCV in terms of curability?

    <p>HCV is curable, while HBV is not curable</p> Signup and view all the answers

    What is the mechanism of action of Ribavirin against viral replication?

    <p>It inhibits the production of viral nucleic acids</p> Signup and view all the answers

    What is the advantage of using Interferon for treating viral infections?

    <p>It has low toxicity and modest antigenic properties</p> Signup and view all the answers

    What is the mechanism of action of NTRIs in the treatment of HIV?

    <p>They lack a 3' hydroxyl group preventing further nucleotide attachment to viral DNA</p> Signup and view all the answers

    What is the target of nonnucleoside reverse-transcriptase inhibitors (NNRTIs) in the treatment of HIV?

    <p>Reverse transcriptase</p> Signup and view all the answers

    How do integrase inhibitors interfere with the replication of HIV?

    <p>They prevent the integration of viral DNA into the host chromosome by binding to integrase</p> Signup and view all the answers

    What is the mechanism of action of protease inhibitors in the treatment of HIV?

    <p>They inhibit the activity of the HIV protease enzyme</p> Signup and view all the answers

    Which enzyme is responsible for the first round of phosphorylation in CMV?

    <p>Viral kinase encoded by UL97 gene</p> Signup and view all the answers

    What is the primary goal of antiretroviral therapy for HIV?

    <p>Reduce HIV-associated morbidity and prolong survival</p> Signup and view all the answers

    What is the mechanism of action of nucleoside analogues and nucleotide analogues in the treatment of HIV?

    <p>Arrest the synthesis of viral DNA by reverse transcriptase</p> Signup and view all the answers

    Which of the following drugs binds to gp120 to inhibit HIV-1 entry?

    <p>Fostemsavir</p> Signup and view all the answers

    Which of the following is a nucleoside RT inhibitor used in the treatment of HBV?

    <p>Adefovir</p> Signup and view all the answers

    What is the mechanism of action of Ribavirin against viral replication?

    <p>Inhibition of inosine monophosphate deidrogenase enzyme</p> Signup and view all the answers

    Which of the following is NOT a characteristic of HBV infection?

    <p>Curable</p> Signup and view all the answers

    What is the difference between HCV and HBV in terms of replication?

    <p>HCV replication occurs only in the cytoplasm</p> Signup and view all the answers

    Which of the following human infectious diseases does NOT have drugs for treatment currently available?

    <p>Ebola virus infections</p> Signup and view all the answers

    What are the characteristics of an ideal antiviral drug according to the text?

    <p>Water-soluble, chemically and metabolically stable, easily absorbed (apolar), carcinogenic</p> Signup and view all the answers

    What is the primary goal of therapy and prophylaxis with antiviral drugs during a pandemic according to the text?

    <p>To reduce the number of individuals at risk of getting a disease (morbidity)</p> Signup and view all the answers

    What is the primary target of neuraminidase inhibitors in the treatment of influenza?

    <p>The neuraminidase enzyme</p> Signup and view all the answers

    Which of the following drugs is used to treat cytomegalovirus infections in patients with AIDS?

    <p>Ganciclovir</p> Signup and view all the answers

    What is the mechanism of action of amantadine and rimantadine in the treatment of influenza?

    <p>Blocking the M2 viral proton pump</p> Signup and view all the answers

    What is the primary advantage of acyclovir over guanosine in the treatment of herpes infections?

    <p>Lower concentration necessary to inhibit viral DNA polymerase</p> Signup and view all the answers

    What is the mechanism of action of nonnucleoside reverse-transcriptase inhibitors (NNRTIs) in the treatment of HIV?

    <p>NNRTIs inhibit the activity of reverse transcriptase by binding to a hydrophobic pocket.</p> Signup and view all the answers

    What is the mode of action of integrase inhibitors in the treatment of HIV?

    <p>Integrase inhibitors interfere with the strand transfer process of the viral DNA by competitively binding to the active site of integrase.</p> Signup and view all the answers

    What is the target of protease inhibitors in the treatment of HIV?

    <p>Protease inhibitors inhibit the catalytic activity of HIV protease.</p> Signup and view all the answers

    What is the new long-acting injection treatment option for HIV?

    <p>Cabotegravir and rilpivirine given as two separate injections every two months</p> Signup and view all the answers

    More Like This

    Antiviral Drugs: Oseltamivir and Zanamivir
    36 questions

    Antiviral Drugs: Oseltamivir and Zanamivir

    LowRiskCynicalRealism avatar
    LowRiskCynicalRealism
    Antiviral Drugs Quiz
    40 questions

    Antiviral Drugs Quiz

    InnocuousWashington avatar
    InnocuousWashington
    Antiviral Drugs and Influenza
    40 questions

    Antiviral Drugs and Influenza

    InnocuousWashington avatar
    InnocuousWashington
    Influenza Virus Release Inhibitors
    5 questions

    Influenza Virus Release Inhibitors

    LightHeartedCerberus avatar
    LightHeartedCerberus
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser