CMV and HIV Treatment Goals Quiz
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Questions and Answers

Which of the following is NOT a characteristic of an ideal antiviral drug?

  • Chemically and metabolically stable
  • Easily absorbed (apolar)
  • Water-soluble
  • Toxic (correct)

    • Which of the following is a target of anti-influenza drugs?

  • DNA polymerase
  • RNA polymerase (correct)
  • Reverse transcriptase
  • Protein kinase

    • What is the primary goal of therapy and prophylaxis with antiviral drugs during a pandemic?

  • Spread new virus subtypes
  • Protect people who play key roles in managing the response to pandemic
  • Reduce the number of deaths (correct)
  • Increase the number of individuals at risk of getting a disease

    • Why is it more complex to employ drugs against viruses compared to bacteria?

    <p>Viruses can replicate exclusively in host cells (B)</p> Signup and view all the answers

    Which of the following is NOT a neuraminidase inhibitor?

    <p>Amantadine (B)</p> Signup and view all the answers

    Which drug is used to treat herpes simplex virus and chicken-pox virus?

    <p>Penciclovir (C)</p> Signup and view all the answers

    What is the mechanism of action of neuraminidase inhibitors?

    <p>They block the activity of neuraminidase (C)</p> Signup and view all the answers

    What is the goal of HIV treatment?

    <p>Reduce HIV-associated morbidity and prolong the duration and quality of survival (D)</p> Signup and view all the answers

    What is the role of thymidine kinase in the phosphorylation of CMV?

    <p>Thymidine kinase is absent in CMV (A)</p> Signup and view all the answers

    What makes retroviruses hard to eradicate?

    <p>Integration of their DNA into the host cell's genome is an essential step in the viral replication cycle (C)</p> Signup and view all the answers

    What is the mechanism of action of nucleos(t)ide reverse transcriptase inhibitors?

    <p>They arrest the synthesis of viral DNA by reverse transcriptase (B)</p> Signup and view all the answers

    Which type of drugs can suppress the synthesis of viral genome and viral particles production in HBV?

    <p>Acyclic nucleoside phosphonate analogues (C)</p> Signup and view all the answers

    What is the difference between HBV and HCV in terms of curability?

    <p>HCV is curable, while HBV is not curable (D)</p> Signup and view all the answers

    What is the mechanism of action of Ribavirin against viral replication?

    <p>It inhibits the production of viral nucleic acids (C)</p> Signup and view all the answers

    What is the advantage of using Interferon for treating viral infections?

    <p>It has low toxicity and modest antigenic properties (A)</p> Signup and view all the answers

    What is the mechanism of action of NTRIs in the treatment of HIV?

    <p>They lack a 3' hydroxyl group preventing further nucleotide attachment to viral DNA (C)</p> Signup and view all the answers

    What is the target of nonnucleoside reverse-transcriptase inhibitors (NNRTIs) in the treatment of HIV?

    <p>Reverse transcriptase (B)</p> Signup and view all the answers

    How do integrase inhibitors interfere with the replication of HIV?

    <p>They prevent the integration of viral DNA into the host chromosome by binding to integrase (D)</p> Signup and view all the answers

    What is the mechanism of action of protease inhibitors in the treatment of HIV?

    <p>They inhibit the activity of the HIV protease enzyme (A)</p> Signup and view all the answers

    Which enzyme is responsible for the first round of phosphorylation in CMV?

    <p>Viral kinase encoded by UL97 gene (C)</p> Signup and view all the answers

    What is the primary goal of antiretroviral therapy for HIV?

    <p>Reduce HIV-associated morbidity and prolong survival (B)</p> Signup and view all the answers

    What is the mechanism of action of nucleoside analogues and nucleotide analogues in the treatment of HIV?

    <p>Arrest the synthesis of viral DNA by reverse transcriptase (C)</p> Signup and view all the answers

    Which of the following drugs binds to gp120 to inhibit HIV-1 entry?

    <p>Fostemsavir (D)</p> Signup and view all the answers

    Which of the following is a nucleoside RT inhibitor used in the treatment of HBV?

    <p>Adefovir (D)</p> Signup and view all the answers

    What is the mechanism of action of Ribavirin against viral replication?

    <p>Inhibition of inosine monophosphate deidrogenase enzyme (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of HBV infection?

    <p>Curable (C)</p> Signup and view all the answers

    What is the difference between HCV and HBV in terms of replication?

    <p>HCV replication occurs only in the cytoplasm (B)</p> Signup and view all the answers

    Which of the following human infectious diseases does NOT have drugs for treatment currently available?

    <p>Ebola virus infections (A)</p> Signup and view all the answers

    What are the characteristics of an ideal antiviral drug according to the text?

    <p>Water-soluble, chemically and metabolically stable, easily absorbed (apolar), carcinogenic (C)</p> Signup and view all the answers

    What is the primary goal of therapy and prophylaxis with antiviral drugs during a pandemic according to the text?

    <p>To reduce the number of individuals at risk of getting a disease (morbidity) (C)</p> Signup and view all the answers

    What is the primary target of neuraminidase inhibitors in the treatment of influenza?

    <p>The neuraminidase enzyme (D)</p> Signup and view all the answers

    Which of the following drugs is used to treat cytomegalovirus infections in patients with AIDS?

    <p>Ganciclovir (C)</p> Signup and view all the answers

    What is the mechanism of action of amantadine and rimantadine in the treatment of influenza?

    <p>Blocking the M2 viral proton pump (B)</p> Signup and view all the answers

    What is the primary advantage of acyclovir over guanosine in the treatment of herpes infections?

    <p>Lower concentration necessary to inhibit viral DNA polymerase (B)</p> Signup and view all the answers

    What is the mechanism of action of nonnucleoside reverse-transcriptase inhibitors (NNRTIs) in the treatment of HIV?

    <p>NNRTIs inhibit the activity of reverse transcriptase by binding to a hydrophobic pocket. (D)</p> Signup and view all the answers

    What is the mode of action of integrase inhibitors in the treatment of HIV?

    <p>Integrase inhibitors interfere with the strand transfer process of the viral DNA by competitively binding to the active site of integrase. (A)</p> Signup and view all the answers

    What is the target of protease inhibitors in the treatment of HIV?

    <p>Protease inhibitors inhibit the catalytic activity of HIV protease. (A)</p> Signup and view all the answers

    What is the new long-acting injection treatment option for HIV?

    <p>Cabotegravir and rilpivirine given as two separate injections every two months (D)</p> Signup and view all the answers

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