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Questions and Answers
What is the mechanism of action of antiplatelets?
What is the mechanism of action of antiplatelets?
Which type of antiplatelet irreversibly inhibits COX-1?
Which type of antiplatelet irreversibly inhibits COX-1?
What is the primary indication for antiplatelet therapy?
What is the primary indication for antiplatelet therapy?
What is the mechanism of action of anticoagulants?
What is the mechanism of action of anticoagulants?
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Which type of anticoagulant inhibits thrombin?
Which type of anticoagulant inhibits thrombin?
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What is a common indication for anticoagulant therapy?
What is a common indication for anticoagulant therapy?
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What is the key difference between antiplatelets and anticoagulants?
What is the key difference between antiplatelets and anticoagulants?
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Which of the following is NOT a type of antiplatelet?
Which of the following is NOT a type of antiplatelet?
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Study Notes
Antiplatelets
- Mechanism of action: Inhibit platelet aggregation, preventing formation of thrombi
-
Types:
- Aspirin: Irreversibly inhibits COX-1, reducing thromboxane A2 production
- Thienopyridines: Inhibit P2Y12 receptor, preventing ADP-mediated platelet activation (e.g., clopidogrel, prasugrel)
- Glycoprotein IIb/IIIa inhibitors: Inhibit platelet aggregation by blocking GP IIb/IIIa receptors (e.g., abciximab, eptifibatide)
- P2Y12 receptor antagonists: Reversibly inhibit P2Y12 receptor, preventing ADP-mediated platelet activation (e.g., ticagrelor, cangrelor)
-
Indications:
- Acute coronary syndrome (ACS)
- Percutaneous coronary intervention (PCI)
- Stroke prevention
- Peripheral artery disease
Anticoagulants
- Mechanism of action: Inhibit clotting factor activity or prevent clot formation
-
Types:
- Warfarin: Inhibits vitamin K-dependent clotting factors (II, VII, IX, X)
-
Direct oral anticoagulants (DOACs):
- Direct thrombin inhibitors: Inhibit thrombin (e.g., dabigatran)
- Factor Xa inhibitors: Inhibit FXa (e.g., rivaroxaban, apixaban, edoxaban)
- Heparins: Inhibit thrombin and factor Xa (e.g., unfractionated heparin, low-molecular-weight heparins)
- Fondaparinux: Inhibits factor Xa
-
Indications:
- Atrial fibrillation (AF)
- Venous thromboembolism (VTE) prevention and treatment
- Pulmonary embolism (PE) treatment
- Mechanical heart valve prophylaxis
Key Differences
- Antiplatelets: Inhibit platelet aggregation, primarily used for arterial thrombosis prevention
- Anticoagulants: Inhibit clotting factor activity, primarily used for venous thrombosis prevention and treatment
Antiplatelets
- Inhibit platelet aggregation, preventing formation of thrombi
- Aspirin: Irreversibly inhibits COX-1, reducing thromboxane A2 production
- Thienopyridines: Inhibit P2Y12 receptor, preventing ADP-mediated platelet activation
- Glycoprotein IIb/IIIa inhibitors: Inhibit platelet aggregation by blocking GP IIb/IIIa receptors
- P2Y12 receptor antagonists: Reversibly inhibit P2Y12 receptor, preventing ADP-mediated platelet activation
- Indicated for:
- Acute coronary syndrome (ACS)
- Percutaneous coronary intervention (PCI)
- Stroke prevention
- Peripheral artery disease
Anticoagulants
- Inhibit clotting factor activity or prevent clot formation
- Warfarin: Inhibits vitamin K-dependent clotting factors (II, VII, IX, X)
-
Direct oral anticoagulants (DOACs):
- Direct thrombin inhibitors: Inhibit thrombin
- Factor Xa inhibitors: Inhibit FXa
- Heparins: Inhibit thrombin and factor Xa
- Fondaparinux: Inhibits factor Xa
- Indicated for:
- Atrial fibrillation (AF)
- Venous thromboembolism (VTE) prevention and treatment
- Pulmonary embolism (PE) treatment
- Mechanical heart valve prophylaxis
Key Differences
- Antiplatelets: Inhibit platelet aggregation, primarily used for arterial thrombosis prevention
- Anticoagulants: Inhibit clotting factor activity, primarily used for venous thrombosis prevention and treatment
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Description
Learn about the mechanism of action of antiplatelets, including their types, indications, and effects on platelet aggregation. Understand how they prevent thrombus formation.
