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Questions and Answers
What is the drug class for Artane?
What is the drug class for Artane?
- Antidepressant
- Antibiotic
- Antiparkinson: anticholinergic agent (correct)
- Antihistamine
What is the pregnancy category of Artane?
What is the pregnancy category of Artane?
- D
- A
- C (correct)
- B
What are the therapeutic uses of Artane?
What are the therapeutic uses of Artane?
To decrease involuntary symptoms of parkinsonism or drug-induced parkinsonism by inhibiting acetylcholine.
What is the mode of action of Artane?
What is the mode of action of Artane?
List some side effects of Artane.
List some side effects of Artane.
What are some adverse reactions associated with Artane?
What are some adverse reactions associated with Artane?
What are the contraindications for using Artane?
What are the contraindications for using Artane?
What can increase the anticholinergic effect when taking Artane?
What can increase the anticholinergic effect when taking Artane?
What is the absorption method of Artane?
What is the absorption method of Artane?
What is the elimination method for Artane?
What is the elimination method for Artane?
What is the peak onset time for the oral administration of Artane?
What is the peak onset time for the oral administration of Artane?
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Study Notes
Drug Class
- Antiparkinson: categorized as an anticholinergic agent.
Pregnancy Category
- Classified as Category C, indicating potential risks that cannot be ruled out.
Therapeutic Uses
- Used to reduce involuntary symptoms associated with parkinsonism or drug-induced parkinsonism.
- Functions by inhibiting acetylcholine to diminish symptoms.
Mode of Action
- Acts by blocking cholinergic (muscarinic) receptors, leading to a reduction in involuntary movements.
Side Effects
- Common side effects include:
- Nausea and vomiting
- Dry mouth
- Constipation
- Anxiety and restlessness
- Headache and dizziness
- Blurred vision and photophobia
- Pupil dilation and dysphagia
Adverse Reactions
- Serious adverse reactions can include:
- Tachycardia and palpitations
- Postural hypotension and urinary retention
- Life-threatening condition: paralytic ileus
Contraindications
- Not recommended for individuals with:
- Narrow angle glaucoma
- GI obstruction
- Urinary retention
- Severe angina pectoris
- Myasthenia gravis
- Use with caution in patients with tachycardia, benign prostatic hypertrophy, children, older adults, and nursing mothers.
Drug Interactions
- Can enhance anticholinergic effects when combined with:
- Phenothiazines
- Antihistamines
- Tricyclic antidepressants
- Amantadine and quinidine
- Antacids may decrease the absorption of Artane.
Pharmacokinetics
- Well absorbed when taken orally.
- Protein binding: unknown percentage.
- Half-life of 5-10 hours.
- Primarily excreted in urine.
Pharmacodynamics
- Immediate-release form (PO):
- Onset of action: 1 hour
- Peak effect: 2-3 hours
- Duration of effect: 6-12 hours
- Sustained-release/oral form (SR/PO):
- Onset and peak effects: unknown
- Duration of effect: 12-24 hours
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