45 Questions
Which antibiotic is used to treat TB and works by inhibiting mRNA synthesis?
Rifampicin
What is the mechanism of action of Fluoroquinolones?
Inhibiting DNA gyrase function
Which antibiotic is a time-dependent killer and works by inhibiting peptidoglycan synthesis?
Vancomycin
What is the mechanism of resistance to macrolides?
Modification of the antibiotic target
Which antibiotic is contraindicated in patients with renal impairment?
Vancomycin
What is the parent drug of Fluoroquinolones?
Nalidixic acid
Which beta-lactam antibiotic is used to treat osteomyelitis?
Vancomycin
What is the mechanism of action of beta-lactam antibiotics?
Inhibiting cell wall synthesis
Which antibiotic is used to treat H. pylori infections?
Amoxicillin
What is the mechanism of action of Amino-PCN’s?
Extended spectrum of activity against gram + and - organisms
What is the mechanism of action of Linezolid?
Inhibiting the formation of the 70s ribosomal initiation complex
What is the mechanism of action of Metronidazole?
Increasing the formation of reactive oxygen species
What is the excretion pathway of Clarithromycin?
Renal and biliary excretion
Which of the following antibiotics is contraindicated in patients with renal or liver impairment?
Metronidazole
What is the effect of Clindamycin on the production of toxic shock and other toxins?
Inhibits the production of toxic shock and other toxins
What is the mechanism of action of Lincosamide antibiotics?
Inhibiting bacterial protein synthesis by blocking the formation of the 50s ribosomal initiation complex
What is the type of antibiotic activity exhibited by Clindamycin at high concentrations?
Bactericidal
Which of the following antibiotics has bactericidal activity against anaerobes?
Metronidazole
What is the spectrum of activity of Clarithromycin?
Same as Erythromycin
What is the primary mechanism of action of tetracyclines in bacteria?
Inhibition of protein synthesis at the 50S ribosome subunit
What is the activity of Linezolid against most organisms?
Bacteriostatic
Which antibiotic is effective against MRSA and is often used in combination with sulfamethoxazole?
Trimethoprim
What is the primary mechanism of resistance to macrolides in bacteria?
Modification of 50S subunit binding site
Which of the following antibiotics is NOT affected by food interference?
Doxycycline
What is a common adverse effect of tetracyclines in children under 12 years old?
Teeth discoloration
What is the primary mechanism of action of sulfamethoxazole-trimethoprim (Bactrim)?
Inhibition of folic acid synthesis
What is the mechanism of absorption of tetracyclines in the gut?
Passive diffusion
Which of the following macrolides has the best spectrum of activity against Haemophilus influenzae?
Azithromycin
What is the primary route of excretion for erythromycin?
Biliary excretion
What is the common adverse effect of macrolides that is often remembered using the acronym 'MACRO'?
All of the above
Which type of antibiotic is used for the treatment of severe infections of resistant bacteria?
Carbapenems
What is the mechanism of beta-lactamase inhibitors?
Suicide inactivation of beta-lactamases
What is the primary mechanism of action of Aminoglycosides?
Inhibition of protein synthesis
What is a common adverse effect of Aminoglycosides?
All of the above
Which antibiotic is an example of a Ureidopenicillin?
Piperacillin
What is the mechanism of resistance to Aminoglycosides?
All of the above
Which generation of Cephalosporins is Cefotaxime?
3rd generation
What is the primary use of topical Aminoglycosides?
Short-term therapy for ophthalmic use
Which antibiotic is an example of a Monobactam?
Aztreonam
What is the primary mechanism of action of Carbapenems?
Inhibition of cell wall synthesis
What is the mechanism of action of Amoxicillin?
Disrupts bacterial cell wall
Why is Metronidazole often used in antibiotic ulcer treatment?
Due to bacterial resistance to Amoxicillin and Tetracycline
What is the mechanism of action of Clarithromycin?
Inhibits protein synthesis
What is the purpose of combining Bismuth with Amoxicillin in antibiotic ulcer treatment?
To disrupt bacterial cell wall
What is the reason for using Metronidazole instead of Tetracycline in antibiotic ulcer treatment?
Bacterial resistance to Tetracycline
Test your knowledge of macrolides and oxazolidinones, a class of antimicrobial agents that inhibit bacterial protein synthesis. This quiz covers their mechanisms of action, spectra of activity, and pharmacokinetics. Review the properties of erythromycin, clarithromycin, and linezolid to ace this quiz!
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