Podcast
Questions and Answers
What is the function of proteasomes in the class I MHC pathway?
What is the function of proteasomes in the class I MHC pathway?
- Process peptide antigens in the cytosol (correct)
- Degrade protein antigens in lysosomes
- Transport peptides into the ER
- Bind peptides to class I MHC molecules
Where are protein antigens degraded in the class II MHC pathway?
Where are protein antigens degraded in the class II MHC pathway?
- Endoplasmic reticulum
- Cytosol
- Lysosomes (correct)
- ER
Which molecules are involved in transporting peptides into the ER in the class I MHC pathway?
Which molecules are involved in transporting peptides into the ER in the class I MHC pathway?
- Proteasomes
- Lysosomes
- Class I MHC molecules
- TAP proteins (correct)
In which stage of antigen presentation do dendritic cells capture antigens for transport?
In which stage of antigen presentation do dendritic cells capture antigens for transport?
What is the role of dendritic cells in antigen capture and presentation?
What is the role of dendritic cells in antigen capture and presentation?
How do T cells recognize peptide antigens?
How do T cells recognize peptide antigens?
Which cell type transports antigens captured through the skin to regional lymph nodes?
Which cell type transports antigens captured through the skin to regional lymph nodes?
Which proteins are responsible for producing a variety of peptides from natural proteins in the antigen processing pathway?
Which proteins are responsible for producing a variety of peptides from natural proteins in the antigen processing pathway?
In cancer, mutated gene peptides are analyzed for their ability to bind to which molecules in the patient?
In cancer, mutated gene peptides are analyzed for their ability to bind to which molecules in the patient?
Which type of peptides are most likely to stimulate antitumor immunity in a cancer patient?
Which type of peptides are most likely to stimulate antitumor immunity in a cancer patient?
Which term is used interchangeably with 'cytosolic' when referring to antigens?
Which term is used interchangeably with 'cytosolic' when referring to antigens?
What do immunodominant peptides possess that enable them to bind to MHC molecules?
What do immunodominant peptides possess that enable them to bind to MHC molecules?
Which organelle is responsible for generating multiple peptides from protein antigens?
Which organelle is responsible for generating multiple peptides from protein antigens?
What does TAP (Transporter associated with Antigen Processing) protein function in?
What does TAP (Transporter associated with Antigen Processing) protein function in?
Where do Langerhans cells of the epidermis develop from?
Where do Langerhans cells of the epidermis develop from?
What is the function of TAP1 and TAP2 proteins in the MHC-I antigen presentation pathway?
What is the function of TAP1 and TAP2 proteins in the MHC-I antigen presentation pathway?
Where are peptides that bind to MHC Class II molecules generated?
Where are peptides that bind to MHC Class II molecules generated?
Which enzyme is responsible for trimming peptides that are too long to bind to MHC-I molecules?
Which enzyme is responsible for trimming peptides that are too long to bind to MHC-I molecules?
What happens to the MHC-II/CLIP complex in the antigen presentation pathway?
What happens to the MHC-II/CLIP complex in the antigen presentation pathway?
In which organelle do MHC-II molecules assemble with the invariant chain Ii?
In which organelle do MHC-II molecules assemble with the invariant chain Ii?
What is the essential step in the process of cross-presentation by Type 1 cDCs?
What is the essential step in the process of cross-presentation by Type 1 cDCs?
Which subset of dendritic cells is specifically important for initiating responses by presenting captured antigens to CD4 + T cells?
Which subset of dendritic cells is specifically important for initiating responses by presenting captured antigens to CD4 + T cells?
What is the major source of type I IFN and essential for innate immune responses to viruses?
What is the major source of type I IFN and essential for innate immune responses to viruses?
Which dendritic cell subset is enriched in lymphoid organs and transports antigens to secondary lymphoid organs?
Which dendritic cell subset is enriched in lymphoid organs and transports antigens to secondary lymphoid organs?
Which dendritic cell type captures antigens and transports them to the spleen from the blood?
Which dendritic cell type captures antigens and transports them to the spleen from the blood?
What is the function of Type 2 cDCs in antigen presentation?
What is the function of Type 2 cDCs in antigen presentation?
Which dendritic cell subset is especially efficient at transferring ingested antigens from vesicles into the cytosol?
Which dendritic cell subset is especially efficient at transferring ingested antigens from vesicles into the cytosol?
Which dendritic cell subset is mainly present in most epithelia that interface with the external environment?
Which dendritic cell subset is mainly present in most epithelia that interface with the external environment?
What is the primary role of Plasmacytoid DCs (pDC) in innate immunity?
What is the primary role of Plasmacytoid DCs (pDC) in innate immunity?
