Podcast
Questions and Answers
What is the primary function of antigen presenting cells?
What is the primary function of antigen presenting cells?
What type of complex is involved in presenting antigens on the surface of antigen presenting cells?
What type of complex is involved in presenting antigens on the surface of antigen presenting cells?
Which of the following cells is NOT a professional antigen presenting cell?
Which of the following cells is NOT a professional antigen presenting cell?
What is the term for the compatibility of tissues?
What is the term for the compatibility of tissues?
Signup and view all the answers
What is the function of membrane-bound antibodies on B cells?
What is the function of membrane-bound antibodies on B cells?
Signup and view all the answers
What type of cells can present antigens in conjunction with MHC II complexes?
What type of cells can present antigens in conjunction with MHC II complexes?
Signup and view all the answers
What happens to the pathogen after it is internalized by an antigen presenting cell?
What happens to the pathogen after it is internalized by an antigen presenting cell?
Signup and view all the answers
What is the main difference between MHC I and MHC II complexes?
What is the main difference between MHC I and MHC II complexes?
Signup and view all the answers
What happens to an activated T cell?
What happens to an activated T cell?
Signup and view all the answers
What is the primary function of effector T cells?
What is the primary function of effector T cells?
Signup and view all the answers
What is the role of perforins in cytotoxic T cells?
What is the role of perforins in cytotoxic T cells?
Signup and view all the answers
What is the difference between cytotoxic T cells and B cells?
What is the difference between cytotoxic T cells and B cells?
Signup and view all the answers
What is the purpose of granzymes in cytotoxic T cells?
What is the purpose of granzymes in cytotoxic T cells?
Signup and view all the answers
What happens when a cytotoxic T cell binds to a cancer cell?
What happens when a cytotoxic T cell binds to a cancer cell?
Signup and view all the answers
Why are cytotoxic T cells important in fighting cancer?
Why are cytotoxic T cells important in fighting cancer?
Signup and view all the answers
What is the significance of MHC class I complex in this context?
What is the significance of MHC class I complex in this context?
Signup and view all the answers
What is the primary function of MHC I complex in the human body?
What is the primary function of MHC I complex in the human body?
Signup and view all the answers
Which type of cells in the human body do not have a nucleus?
Which type of cells in the human body do not have a nucleus?
Signup and view all the answers
What is the role of cytotoxic T cells in the immune response?
What is the role of cytotoxic T cells in the immune response?
Signup and view all the answers
What is the purpose of MHC II complexes in the immune response?
What is the purpose of MHC II complexes in the immune response?
Signup and view all the answers
How do helper T cells and cytotoxic T cells recognize specific antigens?
How do helper T cells and cytotoxic T cells recognize specific antigens?
Signup and view all the answers
What is the mechanism that generates variability in the T cell receptors and membrane-bound antibodies?
What is the mechanism that generates variability in the T cell receptors and membrane-bound antibodies?
Signup and view all the answers
Which type of cells can present abnormal or foreign proteins on their MHC I complex?
Which type of cells can present abnormal or foreign proteins on their MHC I complex?
Signup and view all the answers
What is the function of the variable portion of the T cell receptor?
What is the function of the variable portion of the T cell receptor?
Signup and view all the answers
What is the outcome when a cytotoxic T cell recognizes an MHC I complex presenting abnormal or foreign proteins?
What is the outcome when a cytotoxic T cell recognizes an MHC I complex presenting abnormal or foreign proteins?
Signup and view all the answers
What is the difference between MHC I and MHC II complexes in terms of their interaction with T cells?
What is the difference between MHC I and MHC II complexes in terms of their interaction with T cells?
Signup and view all the answers
Study Notes
Antigen Presenting Cells
- Dendritic cells are phagocytes and antigen presenting cells that digest pathogens, cut them up, and present the antigen on their surface with an MHC type II complex.
- B cells also present antigens on their surface with an MHC II complex after internalizing and processing pathogens.
MHC Complexes
- MHC stands for major histocompatibility complex, which means tissue compatibility.
- MHC II complexes are found on professional antigen presenting cells, such as dendritic cells and B cells.
- MHC I complexes are found on almost all nucleated cells in the human body, except for red blood cells.
MHC I Complex Function
- MHC I complexes present pieces of viral or cancer proteins on the cell surface, signaling to cytotoxic T cells that the cell is infected or cancerous and needs to be killed.
- This is a way for the cell to communicate with the immune system when it has been infected or has become cancerous.
T Cells
- Helper T cells bond to MHC II complexes on antigen presenting cells, leading to activation and differentiation into effector and memory cells.
- Cytotoxic T cells bond to MHC I complexes on infected or cancerous cells, leading to activation and differentiation into effector and memory cells.
- T cell receptors have a non-variable portion and a variable portion that is specific to the combination of antigen and MHC complex.
Cytotoxic T Cell Function
- Cytotoxic T cells are activated when they bond to MHC I complexes on infected or cancerous cells.
- Activated cytotoxic T cells divide, differentiate, and release cytotoxins, such as perforins and granzymes, which kill the infected or cancerous cell.
- Cytotoxic T cells are responsible for killing cells that have gone awry, such as cancer cells or virus-infected cells.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
This quiz covers the process of antigen presentation by dendritic cells, including phagocytosis and display of pathogens on their surface. Understand the role of dendritic cells as phagocytes and antigen-presenting cells.