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Questions and Answers
What is a common way to put the brakes on excitation of neurons?
What is a common way to put the brakes on excitation of neurons?
- Block GABA transporters
- Block GABA-transaminase
- Promote GABA-A activation
- Block excitatory glutamate receptor signaling (correct)
What is a rare but serious adverse effect associated with voltage-gated Na+ channel blockers?
What is a rare but serious adverse effect associated with voltage-gated Na+ channel blockers?
- Muscle cramps
- Delayed hypersensitivity (correct)
- Headache
- Constipation
What is the mechanism of action of lamotrigine?
What is the mechanism of action of lamotrigine?
- Promote GABA-A activation
- Reduce synaptic vesicle machinery
- Facilitate transition to inactivated state of VGSC (correct)
- Block voltage-gated Ca+ channels
Which enzyme is responsible for the metabolism of phenytoin?
Which enzyme is responsible for the metabolism of phenytoin?
What is a characteristic feature of phenytoin (Dilantin) due to the benzene rings?
What is a characteristic feature of phenytoin (Dilantin) due to the benzene rings?
What is the main mechanism of action of fosphenytoin?
What is the main mechanism of action of fosphenytoin?
Which enzyme metabolizes fosphenytoin?
Which enzyme metabolizes fosphenytoin?
What is the Black Box Warning associated with phenytoin (Dilantin) and fosphenytoin?
What is the Black Box Warning associated with phenytoin (Dilantin) and fosphenytoin?
Which of the following is NOT a use of carbamazepine (Tegretol)?
Which of the following is NOT a use of carbamazepine (Tegretol)?
What enzyme metabolizes carbamazepine (Tegretol)?
What enzyme metabolizes carbamazepine (Tegretol)?
What is the active metabolite of oxcarbazepine (Trileptal)?
What is the active metabolite of oxcarbazepine (Trileptal)?
What is the mechanism of action of gabapentin enacarbil?
What is the mechanism of action of gabapentin enacarbil?
Which condition is NOT among the uses of pregabalin (Lyrica)?
Which condition is NOT among the uses of pregabalin (Lyrica)?
What is the primary mechanism of action of levetiracetam (Keppra) and brivaracetam?
What is the primary mechanism of action of levetiracetam (Keppra) and brivaracetam?
What is the enantiomer configuration of Pregabalin (Lyrica)?
What is the enantiomer configuration of Pregabalin (Lyrica)?
Which neurotransmitter receptor is antagonized by topiramate (Topamax)?
Which neurotransmitter receptor is antagonized by topiramate (Topamax)?
What is the prodrug of eslicarbazepine?
What is the prodrug of eslicarbazepine?
What is the MOA of cenobamate (Xcopri)?
What is the MOA of cenobamate (Xcopri)?
What are the 2 active metabolites of primidone?
What are the 2 active metabolites of primidone?
How is cenobamate (Xcopri) metabolized?
How is cenobamate (Xcopri) metabolized?
What is the main concern associated with the use of perampanel (Fycompa)?
What is the main concern associated with the use of perampanel (Fycompa)?
Which enzyme is responsible for metabolizing felbamate (Felbatol)?
Which enzyme is responsible for metabolizing felbamate (Felbatol)?
What is the mechanism of action of tiagabine (Gabitril) in treating seizures?
What is the mechanism of action of tiagabine (Gabitril) in treating seizures?
Which adverse effect is specifically associated with vigabatrin (Sabril) use?
Which adverse effect is specifically associated with vigabatrin (Sabril) use?
What is the primary mechanism of action of barbiturates in managing seizures?
What is the primary mechanism of action of barbiturates in managing seizures?
Which of the following is NOT a benzodiazepine used for seizures?
Which of the following is NOT a benzodiazepine used for seizures?
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