26 Questions
What is a common way to put the brakes on excitation of neurons?
Block excitatory glutamate receptor signaling
What is a rare but serious adverse effect associated with voltage-gated Na+ channel blockers?
Delayed hypersensitivity
What is the mechanism of action of lamotrigine?
Facilitate transition to inactivated state of VGSC
Which enzyme is responsible for the metabolism of phenytoin?
2C9 and 2C19
What is a characteristic feature of phenytoin (Dilantin) due to the benzene rings?
Acidic pH
What is the main mechanism of action of fosphenytoin?
Blockade of voltage-gated sodium channels
Which enzyme metabolizes fosphenytoin?
3A and 2C19
What is the Black Box Warning associated with phenytoin (Dilantin) and fosphenytoin?
CV risk with rapid infusion
Which of the following is NOT a use of carbamazepine (Tegretol)?
Anxiety disorder
What enzyme metabolizes carbamazepine (Tegretol)?
3A4
What is the active metabolite of oxcarbazepine (Trileptal)?
Lizcarbazepine
What is the mechanism of action of gabapentin enacarbil?
Binds to alpha-2 delta voltage-gated Ca+2 calcium channel
Which condition is NOT among the uses of pregabalin (Lyrica)?
Hypertension
What is the primary mechanism of action of levetiracetam (Keppra) and brivaracetam?
SV2A binding and disruption of exocytosis
What is the enantiomer configuration of Pregabalin (Lyrica)?
S
Which neurotransmitter receptor is antagonized by topiramate (Topamax)?
Glutamate receptors (AMPA, KA-R)
What is the prodrug of eslicarbazepine?
Eslicarbazepine acetate
What is the MOA of cenobamate (Xcopri)?
Blocks voltage-gated Na+ channels and GABA-A PAM
What are the 2 active metabolites of primidone?
Phenobarbital, PEMA
How is cenobamate (Xcopri) metabolized?
Glucoronidation and multiple CYPs
What is the main concern associated with the use of perampanel (Fycompa)?
Psychiatric and behavioral reactions
Which enzyme is responsible for metabolizing felbamate (Felbatol)?
3A4
What is the mechanism of action of tiagabine (Gabitril) in treating seizures?
Inhibiting GABA transporter GAT-1
Which adverse effect is specifically associated with vigabatrin (Sabril) use?
Permanent vision loss
What is the primary mechanism of action of barbiturates in managing seizures?
Potentiation of GABA-A receptors
Which of the following is NOT a benzodiazepine used for seizures?
Epidiolex
Test your knowledge about antiepileptic medications such as eslicarbazepine acetate and lamotrigine (Lamictil). Learn about prodrugs, mechanisms of action, clinical uses, and metabolism of these drugs.
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