Antiepileptic Medications Quiz
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Questions and Answers

What is a common way to put the brakes on excitation of neurons?

  • Block GABA transporters
  • Block GABA-transaminase
  • Promote GABA-A activation
  • Block excitatory glutamate receptor signaling (correct)
  • What is a rare but serious adverse effect associated with voltage-gated Na+ channel blockers?

  • Muscle cramps
  • Delayed hypersensitivity (correct)
  • Headache
  • Constipation
  • What is the mechanism of action of lamotrigine?

  • Promote GABA-A activation
  • Reduce synaptic vesicle machinery
  • Facilitate transition to inactivated state of VGSC (correct)
  • Block voltage-gated Ca+ channels
  • Which enzyme is responsible for the metabolism of phenytoin?

    <p>2C9 and 2C19</p> Signup and view all the answers

    What is a characteristic feature of phenytoin (Dilantin) due to the benzene rings?

    <p>Acidic pH</p> Signup and view all the answers

    What is the main mechanism of action of fosphenytoin?

    <p>Blockade of voltage-gated sodium channels</p> Signup and view all the answers

    Which enzyme metabolizes fosphenytoin?

    <p>3A and 2C19</p> Signup and view all the answers

    What is the Black Box Warning associated with phenytoin (Dilantin) and fosphenytoin?

    <p>CV risk with rapid infusion</p> Signup and view all the answers

    Which of the following is NOT a use of carbamazepine (Tegretol)?

    <p>Anxiety disorder</p> Signup and view all the answers

    What enzyme metabolizes carbamazepine (Tegretol)?

    <p>3A4</p> Signup and view all the answers

    What is the active metabolite of oxcarbazepine (Trileptal)?

    <p>Lizcarbazepine</p> Signup and view all the answers

    What is the mechanism of action of gabapentin enacarbil?

    <p>Binds to alpha-2 delta voltage-gated Ca+2 calcium channel</p> Signup and view all the answers

    Which condition is NOT among the uses of pregabalin (Lyrica)?

    <p>Hypertension</p> Signup and view all the answers

    What is the primary mechanism of action of levetiracetam (Keppra) and brivaracetam?

    <p>SV2A binding and disruption of exocytosis</p> Signup and view all the answers

    What is the enantiomer configuration of Pregabalin (Lyrica)?

    <p>S</p> Signup and view all the answers

    Which neurotransmitter receptor is antagonized by topiramate (Topamax)?

    <p>Glutamate receptors (AMPA, KA-R)</p> Signup and view all the answers

    What is the prodrug of eslicarbazepine?

    <p>Eslicarbazepine acetate</p> Signup and view all the answers

    What is the MOA of cenobamate (Xcopri)?

    <p>Blocks voltage-gated Na+ channels and GABA-A PAM</p> Signup and view all the answers

    What are the 2 active metabolites of primidone?

    <p>Phenobarbital, PEMA</p> Signup and view all the answers

    How is cenobamate (Xcopri) metabolized?

    <p>Glucoronidation and multiple CYPs</p> Signup and view all the answers

    What is the main concern associated with the use of perampanel (Fycompa)?

    <p>Psychiatric and behavioral reactions</p> Signup and view all the answers

    Which enzyme is responsible for metabolizing felbamate (Felbatol)?

    <p>3A4</p> Signup and view all the answers

    What is the mechanism of action of tiagabine (Gabitril) in treating seizures?

    <p>Inhibiting GABA transporter GAT-1</p> Signup and view all the answers

    Which adverse effect is specifically associated with vigabatrin (Sabril) use?

    <p>Permanent vision loss</p> Signup and view all the answers

    What is the primary mechanism of action of barbiturates in managing seizures?

    <p>Potentiation of GABA-A receptors</p> Signup and view all the answers

    Which of the following is NOT a benzodiazepine used for seizures?

    <p>Epidiolex</p> Signup and view all the answers

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