Questions and Answers
What is the primary concern regarding Hr-mdr and rpx-resistant S.maltophilia isolates?
In what type of patients were multi-centric analyses conducted?
What concentration of cotrimoxazole was used to define gemocin-resistant S.maltophilia isolates?
What was the outcome of using combination therapy in patients with resistant isolates?
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What percentage of isolates were summarized as resistant?
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What was associated with the use of pan-resistant strains?
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How many patients received trimethoprim-sulfamethoxazole either alone or in combination?
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What type of study designs are suggested to lead to controlled intervention crochet as confident best-community practice?
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What is the primary concern regarding the treatment of Stenotrophomonas maltophilia infections?
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Which of the following is NOT a typical characteristic of Stenotrophomonas maltophilia?
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What is the significance of Stenotrophomonas maltophilia colonization in critical individuals?
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Which antibiotic has been associated with significant toxicities in the treatment of Stenotrophomonas maltophilia infections?
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What is the primary reason for the increasing awareness of Stenotrophomonas maltophilia infections?
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What is the characteristic of pan-resistant Stenotrophomonas maltophilia strains?
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Which of the following patient populations is most susceptible to Stenotrophomonas maltophilia infections?
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What is the novel sulbactam-based β-lactamase inhibiting combination that has in vitro activity against Stenotrophomonas maltophilia?
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What is the significance of Stenotrophomonas maltophilia in hospital-acquired infections?
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What is the common habitat of Stenotrophomonas maltophilia?
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Study Notes
Antibiotic Resistance and Stenotrophomonas maltophilia
- Lacking endpoint studies and sufficient evidence of the dangers of the international spread of Hr-mdr and rpx-resistant S. maltophilia isolates
- Multiple antibiotic regimens suggested for empirical therapy due to limited options
Characteristics of Stenotrophomonas maltophilia
- Typically resistant to most antimicrobial agents, except for sulfamethoxazole/trimethoprim, quinolones, or inhaled antimicrobial agents (aminoglycosides, colistin)
- Found in various environments: food, plants, humans, animals, dust, fiber pellets, and aquatic environments
- Also isolated from the respiratory secretions of healthy humans
Infections caused by S. maltophilia
- Hospital-acquired infections: bacteremia, pneumonia, and urinary tract infections
- Predominantly affect people who have:
- Leukemia
- Cancer (especially those who have had stem cell or organ transplants)
- Require critical care support
Treatment Challenges
- High treatment failure of combination regimens, including trimethoprim-sulfamethoxazole
- Colistin associated with significant toxicities (nephrotoxicity and neurotoxicity)
- Need for new therapeutic options, especially after 10 years of warnings about antibiotic efficacy
Emerging Therapies
- Novel sulbactam-based β-lactamase inhibiting combination cefiderocol has in vitro activity against Stenotrophomonas
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Description
This quiz assesses knowledge on antibiotic resistance in Gram-negative strains, effective therapies, and balancing treatment options. It covers national rates of sensitivity to resistant agents and the dilemma of deprescribing empirical broad-spectrum regimens.