Podcast
Questions and Answers
What is the primary concern regarding Hr-mdr and rpx-resistant S.maltophilia isolates?
What is the primary concern regarding Hr-mdr and rpx-resistant S.maltophilia isolates?
- Their association with immunosuppressants
- Their resistance to minocycline and levofloxacin
- The lack of proper end-point studies to assess their dangers (correct)
- Their lack of response to cotrimoxazole
In what type of patients were multi-centric analyses conducted?
In what type of patients were multi-centric analyses conducted?
- Critically ill pediatric patients
- Patients with Acinetobacter infections
- Critically ill adult patients (correct)
- Patients with pneumonia and/or sepsis
What concentration of cotrimoxazole was used to define gemocin-resistant S.maltophilia isolates?
What concentration of cotrimoxazole was used to define gemocin-resistant S.maltophilia isolates?
- ≥0.250 μg/mL (correct)
- ≥0.500 μg/mL
- ≥0.100 μg/mL
- ≥1.000 μg/mL
What was the outcome of using combination therapy in patients with resistant isolates?
What was the outcome of using combination therapy in patients with resistant isolates?
What percentage of isolates were summarized as resistant?
What percentage of isolates were summarized as resistant?
What was associated with the use of pan-resistant strains?
What was associated with the use of pan-resistant strains?
How many patients received trimethoprim-sulfamethoxazole either alone or in combination?
How many patients received trimethoprim-sulfamethoxazole either alone or in combination?
What type of study designs are suggested to lead to controlled intervention crochet as confident best-community practice?
What type of study designs are suggested to lead to controlled intervention crochet as confident best-community practice?
What is the primary concern regarding the treatment of Stenotrophomonas maltophilia infections?
What is the primary concern regarding the treatment of Stenotrophomonas maltophilia infections?
Which of the following is NOT a typical characteristic of Stenotrophomonas maltophilia?
Which of the following is NOT a typical characteristic of Stenotrophomonas maltophilia?
What is the significance of Stenotrophomonas maltophilia colonization in critical individuals?
What is the significance of Stenotrophomonas maltophilia colonization in critical individuals?
Which antibiotic has been associated with significant toxicities in the treatment of Stenotrophomonas maltophilia infections?
Which antibiotic has been associated with significant toxicities in the treatment of Stenotrophomonas maltophilia infections?
What is the primary reason for the increasing awareness of Stenotrophomonas maltophilia infections?
What is the primary reason for the increasing awareness of Stenotrophomonas maltophilia infections?
What is the characteristic of pan-resistant Stenotrophomonas maltophilia strains?
What is the characteristic of pan-resistant Stenotrophomonas maltophilia strains?
Which of the following patient populations is most susceptible to Stenotrophomonas maltophilia infections?
Which of the following patient populations is most susceptible to Stenotrophomonas maltophilia infections?
What is the novel sulbactam-based β-lactamase inhibiting combination that has in vitro activity against Stenotrophomonas maltophilia?
What is the novel sulbactam-based β-lactamase inhibiting combination that has in vitro activity against Stenotrophomonas maltophilia?
What is the significance of Stenotrophomonas maltophilia in hospital-acquired infections?
What is the significance of Stenotrophomonas maltophilia in hospital-acquired infections?
What is the common habitat of Stenotrophomonas maltophilia?
What is the common habitat of Stenotrophomonas maltophilia?
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Study Notes
Antibiotic Resistance and Stenotrophomonas maltophilia
- Lacking endpoint studies and sufficient evidence of the dangers of the international spread of Hr-mdr and rpx-resistant S. maltophilia isolates
- Multiple antibiotic regimens suggested for empirical therapy due to limited options
Characteristics of Stenotrophomonas maltophilia
- Typically resistant to most antimicrobial agents, except for sulfamethoxazole/trimethoprim, quinolones, or inhaled antimicrobial agents (aminoglycosides, colistin)
- Found in various environments: food, plants, humans, animals, dust, fiber pellets, and aquatic environments
- Also isolated from the respiratory secretions of healthy humans
Infections caused by S. maltophilia
- Hospital-acquired infections: bacteremia, pneumonia, and urinary tract infections
- Predominantly affect people who have:
- Leukemia
- Cancer (especially those who have had stem cell or organ transplants)
- Require critical care support
Treatment Challenges
- High treatment failure of combination regimens, including trimethoprim-sulfamethoxazole
- Colistin associated with significant toxicities (nephrotoxicity and neurotoxicity)
- Need for new therapeutic options, especially after 10 years of warnings about antibiotic efficacy
Emerging Therapies
- Novel sulbactam-based β-lactamase inhibiting combination cefiderocol has in vitro activity against Stenotrophomonas
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