Antibiotics: Types, Spectrum & Mechanisms

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Questions and Answers

Which of the following is classified as a broad-spectrum antibiotic?

  • Polypeptides
  • Polymyxins
  • Tetracyclines (correct)
  • Biosynthetic penicillins

Which antibiotic is considered narrow-spectrum?

  • Aminoglycosides
  • Biosynthetic penicillins (correct)
  • Tetracyclines
  • Cephalosporins

Which antibiotic group is known to act primarily on gram-negative bacteria?

  • Macrolides
  • Biosynthetic penicillins
  • Tetracyclines
  • Polymyxins (correct)

Which of the following antibiotics belongs to the beta-lactam class?

<p>Monobactams (C)</p> Signup and view all the answers

Beta-lactam antibiotics primarily interfere with what bacterial process?

<p>Synthesis of the bacterial cell wall (B)</p> Signup and view all the answers

Which of the following is an example of a biosynthetic penicillin?

<p>Benzylpenicillin sodium salt (D)</p> Signup and view all the answers

What is the effect of oxacillin on the antibacterial activity of ampicillin?

<p>Reinforced (C)</p> Signup and view all the answers

Which of the following antibiotics belongs to the azalide group?

<p>Azithromycin (B)</p> Signup and view all the answers

Which antibiotic has a wide spectrum of activity, is acid-resistant, but not resistant to penicillinase?

<p>Ampicillin (C)</p> Signup and view all the answers

What is a key characteristic of benzylpenicillin preparations?

<p>Not stable in acid environment (A)</p> Signup and view all the answers

Flashcards

Broad-spectrum antibiotics

Effective against a wide range of bacteria, both Gram-positive and Gram-negative.

Narrow-spectrum antibiotics

Effective against only a specific type or group of bacteria.

Polymyxins

Acts primarily on Gram-negative bacteria.

Beta-lactam antibiotics action

Interfere with the synthesis of the bacterial cell wall, leading to bacterial cell death.

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Benzylpenicillin sodium salt

A biosynthetic penicillin example.

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Azithromycin

An antibiotic from the azalide group.

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Benzylpenicillin properties

Unstable in acidic environments.

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Bicillins vs benzylpenicillin

Has a longer duration of action compared to benzylpenicillin sodium salt.

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Tetracyclines' side effect

Can cause liver dysfunction

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Oxacillin

A semi-synthetic penicillin resistant to penicillinase and stable in an acidic environment, effective against gram-positive bacteria.

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Study Notes

  • Broad spectrum antibiotics include tetracyclines.
  • Narrow spectrum antibiotics include biosynthetic penicillins.
  • Polymyxins act only on gram-negative flora.
  • Monobactams are beta lactam antibiotics.
  • Beta-lactam antibiotics interfere with the synthesis of the bacterial cell wall.
  • Biosynthetic penicillins include benzylpenicillin sodium salt.
  • The antibacterial effect of ampicillin is reinforced under the influence of oxacillin.
  • Azithromycin is an antibiotic from the azalide group.
  • Ampicillin has a wide spectrum of antimicrobial activity, is acid resistant, and not resistant to penicillinase.
  • Benzylpenicillin preparations are not stable in an acid environment.
  • Benzylpenicillin sodium salt acts mainly on gram-positive flora, is not resistant to penicillinase, is not stable in an acidic environment, and its duration of action is 3-4 hours.
  • Benzathine benzylpenicillin acts mainly on gram-positive flora, is not resistant to penicillinase, is not stable in an acidic environment, and its duration of action is about 4 weeks.
  • Ampicillin is a semi-synthetic penicillin with a wide spectrum of action.
  • Oxacillin is a semi-synthetic penicillin, resistant to penicillinase, stable in an acidic environment, and acts mainly on gram-positive flora.
  • Benzylpenicillin preparations are used for syphilis.
  • Bicillins act longer, in contrast to benzylpenicillin sodium salt.
  • Tetracyclines causes liver dysfunction.

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