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Drug Treatment of Tuberculosis Quiz

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Questions and Answers

What is the primary or first-line drug that is considered the most active against TB?

Streptomycin

Rifampin (correct)

Ethambutal

Pyrazinamide

What is the mechanism by which Isoniazid (INH) exerts its bactericidal effect in growing TB cells?

Inhibition of protein synthesis

Activation by KatG (correct)

Inhibition of DNA replication

Disruption of cell membrane integrity

What is the probability of resistance when Isoniazid (INH) is used in combination with other drugs?

$1 \times 10^{8}$

$1 \times 10^{4}$

$1 \times 10^{6}$

$1 \times 10^{12}$ (correct)

What adverse reaction is associated with Isoniazid (INH) in about 1% of cases?

Hepatitis Signup and view all the answers

Which drug is metabolized by acetylation?

Isoniazid (INH) Signup and view all the answers

Which bacterium is the primary target for Rifampin?

Mycobacterium tuberculosis Signup and view all the answers

What is the mechanism of action of Rifampin?

Inhibition of bacterial RNA synthesis Signup and view all the answers

Which symptom is NOT associated with Rifampin toxicity?

Bradycardia Signup and view all the answers

What is the primary action of Streptomycin in treating tuberculosis?

Inhibition of protein synthesis Signup and view all the answers

What is the mechanism of action for Ethionamide in treating tuberculosis?

Blocks mycolic acid synthesis Signup and view all the answers