Podcast
Questions and Answers
What is the primary or first-line drug that is considered the most active against TB?
What is the primary or first-line drug that is considered the most active against TB?
- Streptomycin
- Rifampin (correct)
- Ethambutal
- Pyrazinamide
What is the mechanism by which Isoniazid (INH) exerts its bactericidal effect in growing TB cells?
What is the mechanism by which Isoniazid (INH) exerts its bactericidal effect in growing TB cells?
- Inhibition of protein synthesis
- Activation by KatG (correct)
- Inhibition of DNA replication
- Disruption of cell membrane integrity
What is the probability of resistance when Isoniazid (INH) is used in combination with other drugs?
What is the probability of resistance when Isoniazid (INH) is used in combination with other drugs?
- $1 \times 10^{8}$
- $1 \times 10^{4}$
- $1 \times 10^{6}$
- $1 \times 10^{12}$ (correct)
What adverse reaction is associated with Isoniazid (INH) in about 1% of cases?
What adverse reaction is associated with Isoniazid (INH) in about 1% of cases?
Which drug is metabolized by acetylation?
Which drug is metabolized by acetylation?
Which bacterium is the primary target for Rifampin?
Which bacterium is the primary target for Rifampin?
What is the mechanism of action of Rifampin?
What is the mechanism of action of Rifampin?
Which symptom is NOT associated with Rifampin toxicity?
Which symptom is NOT associated with Rifampin toxicity?
What is the primary action of Streptomycin in treating tuberculosis?
What is the primary action of Streptomycin in treating tuberculosis?
What is the mechanism of action for Ethionamide in treating tuberculosis?
What is the mechanism of action for Ethionamide in treating tuberculosis?
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