Antibiotics Mechanism of Action Quiz
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Questions and Answers

Which antibiotic inhibits the synthesis of essential metabolites?

  • Chloramphenicol
  • Sulfonamides (correct)
  • Streptomycin
  • Tetracyclines

Which antibiotic works by inhibiting DNA-directed RNA polymerase?

  • Vancomycin
  • Erythromycin
  • Nalidixic acid (correct)
  • Ciprofloxacin

Which antibiotic inhibits protein synthesis by targeting tRNA?

  • Clindamycin
  • Gentamicin (correct)
  • Rifampin
  • Novobiocin

Which antibiotic has an inhibitory action on the 50S subunit of bacterial ribosomes?

<p>Lincomycin (D)</p> Signup and view all the answers

What is the mode of action of sulfonamides and trimethoprim?

<p>Competitively inhibit formation of Dihydrofolic acid (D)</p> Signup and view all the answers

Which bacteria are commonly affected by the inhibition of precursor synthesis by sulfonamides and trimethoprim?

<p>E. coli and S. pneumoniae (C)</p> Signup and view all the answers

How do trimethoprim antimicrobials inhibit the synthesis of tetrahydrofolic acid?

<p>Bind to the dihydrofolate reductase enzyme (B)</p> Signup and view all the answers

What is the primary effect of inhibition of precursor synthesis by sulfonamides and trimethoprim?

<p>Prevent the formation of nucleotides required for DNA and RNA synthesis (D)</p> Signup and view all the answers

How do aminoglycosides inhibit bacterial protein synthesis?

<p>By binding to the 30S ribosomal subunit and blocking the initiation complex (C)</p> Signup and view all the answers

What is the mode of action of tetracyclines in inhibiting protein synthesis?

<p>Reversibly binding to the 30S ribosome and inhibiting peptide bond formation (A)</p> Signup and view all the answers

Which antibiotics act at the level of the 50S ribosomal subunit to inhibit protein synthesis?

<p>Chloramphenicol (D)</p> Signup and view all the answers

How do aminoglycosides synergize with Beta-lactam antibiotics?

<p>Beta-lactams inhibit cell wall synthesis and thereby increase the permeability of the aminoglycosides (C)</p> Signup and view all the answers

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