12 Questions
Which antibiotic inhibits the synthesis of essential metabolites?
Sulfonamides
Which antibiotic works by inhibiting DNA-directed RNA polymerase?
Nalidixic acid
Which antibiotic inhibits protein synthesis by targeting tRNA?
Gentamicin
Which antibiotic has an inhibitory action on the 50S subunit of bacterial ribosomes?
Lincomycin
What is the mode of action of sulfonamides and trimethoprim?
Competitively inhibit formation of Dihydrofolic acid
Which bacteria are commonly affected by the inhibition of precursor synthesis by sulfonamides and trimethoprim?
E. coli and S. pneumoniae
How do trimethoprim antimicrobials inhibit the synthesis of tetrahydrofolic acid?
Bind to the dihydrofolate reductase enzyme
What is the primary effect of inhibition of precursor synthesis by sulfonamides and trimethoprim?
Prevent the formation of nucleotides required for DNA and RNA synthesis
How do aminoglycosides inhibit bacterial protein synthesis?
By binding to the 30S ribosomal subunit and blocking the initiation complex
What is the mode of action of tetracyclines in inhibiting protein synthesis?
Reversibly binding to the 30S ribosome and inhibiting peptide bond formation
Which antibiotics act at the level of the 50S ribosomal subunit to inhibit protein synthesis?
Chloramphenicol
How do aminoglycosides synergize with Beta-lactam antibiotics?
Beta-lactams inhibit cell wall synthesis and thereby increase the permeability of the aminoglycosides
Test your knowledge of antibiotics mechanism of action with this quiz, which covers topics such as the action of antibiotics on the cell membrane of Gram-positive bacteria, inhibition of protein synthesis, and the specific antibiotics targeting the 30S and 50S ribosomal subunits.
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