Antibacterial Agents
30 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary route of administration for cephalexin?

  • IV
  • Oral (correct)
  • IM
  • Topical

Which generation of cephalosporins is effective against MRSA?

  • Fourth generation
  • First generation
  • Fifth generation (correct)
  • Third generation

What is the primary mechanism of excretion for cephalosporins?

  • Hepatic metabolism
  • Renal excretion (correct)
  • Biliary excretion
  • Salivary excretion

Which of the following cephalosporins does not cross the blood-brain barrier?

<p>Cefaclor (B)</p> Signup and view all the answers

What is the primary indication for piperacillin/tazobactam?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary reason for dose reduction in cephalosporin therapy?

<p>Renal impairment (D)</p> Signup and view all the answers

What is the mechanism of action of β-lactam antimicrobials?

<p>Inhibiting cell wall synthesis by binding to transpeptidase (D)</p> Signup and view all the answers

What is the function of transpeptidase in bacterial cell wall synthesis?

<p>Catalyzing the formation of cross-links between peptide and glycan backbone (B)</p> Signup and view all the answers

What is the primary route of elimination for penicillins?

<p>Renal excretion (B)</p> Signup and view all the answers

Which of the following penicillins is resistant to β-lactamase enzymes?

<p>Flucloxacillin (B)</p> Signup and view all the answers

What is the effect of food on the absorption of amoxicillin?

<p>Decreases absorption (A)</p> Signup and view all the answers

What is the effect of probenecid on the excretion of penicillin?

<p>Decreases excretion (A)</p> Signup and view all the answers

What percentage of cross reactivity is estimated with penicillins?

<p>1-2% (C)</p> Signup and view all the answers

What is the primary Gram positive bacteria covered by 5th generation Cephalosporins?

<p>MRSA and enterococci (C)</p> Signup and view all the answers

What is the primary clinical use of 2nd generation Cephalosporins?

<p>Surgical prophylaxis, UTI, and respiratory tract infections (A)</p> Signup and view all the answers

What is the primary adverse effect of Cephalosporins on the nervous system?

<p>Seizures (C)</p> Signup and view all the answers

What is the primary difference between 3rd generation Cephalosporins (cefotaxime, ceftazidime) and 3rd generation Cephalosporins (ceftazidime)?

<p>Pseudomonas aeruginosa coverage (C)</p> Signup and view all the answers

What is the primary Gram negative bacteria covered by Aztreonam?

<p>Aerobic Gram negative bacilli (A)</p> Signup and view all the answers

What is the primary mechanism of action of glycopeptide antimicrobials?

<p>Inhibit bacterial cell wall synthesis by interacting with the terminal amino acids of the side chain (B)</p> Signup and view all the answers

Which of the following carbapenems does NOT cover Pseudomonas aeruginosa?

<p>Ertapenem (D)</p> Signup and view all the answers

What is the primary route of excretion for carbapenems?

<p>Renal excretion (C)</p> Signup and view all the answers

What is the primary indication for using carbapenems?

<p>Treatment of resistant bacterial infections (A)</p> Signup and view all the answers

What is a common side effect of carbapenem use?

<p>All of the above (D)</p> Signup and view all the answers

Which glycopeptide antibiotic can be used orally for the treatment of C. difficile?

<p>Vancomycin (C)</p> Signup and view all the answers

What is the primary mechanism of action of polymixins?

<p>Interaction with LPS on outer membrane of Gram negative bacteria (A)</p> Signup and view all the answers

What is the primary difference between vancomycin and teicoplanin?

<p>Vancomycin crosses the blood-brain barrier, while teicoplanin does not (A)</p> Signup and view all the answers

What is the primary reason for monitoring serum trough levels of glycopeptides?

<p>To avoid toxicity (A)</p> Signup and view all the answers

What is the primary indication for the use of polymixins?

<p>Treatment of infections caused by multi-resistant Gram negative bacteria (A)</p> Signup and view all the answers

What is the primary side effect of glycopeptides?

<p>Red man syndrome (D)</p> Signup and view all the answers

What is the primary route of administration for polymixins in patients with cystic fibrosis?

<p>Nebulised (C)</p> Signup and view all the answers

More Like This

Use Quizgecko on...
Browser
Browser