15 Questions
What is the benefit of the piperazine ring at position 7 in Norfloxacin?
Improved oral absorption and tissue distribution
Which position substitution greatly increased the antimicrobial activity of Norfloxacin?
Fluorine atom at position 6
What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?
Increased antimicrobial activity
What is the drawback of the piperazine ring at position 7 in Norfloxacin?
Increases binding to human CNS GABA receptors, resulting in CNS side effects
What is the limitation of the spectrum of activity of Norfloxacin?
Limited to a small number of gram negative organisms
What is the role of a single fluorine atom at position 6 in Norfloxacin?
Greatly increased antimicrobial activity and improved penetration into the bacterial cell
What is the drawback of the piperazine ring at position 7 in Norfloxacin?
Increased binding to human CNS GABA receptors, resulting in CNS side effects
What effect does replacing nitrogen at position 8 with CH have on Norfloxacin?
Increased activity
What is the main advantage of the piperazine ring at position 7 in Norfloxacin?
Improved oral absorption, tissue distribution, and metabolic stability
Which organisms are particularly affected by the spectrum of activity of Norfloxacin?
P. aeruginosa
What is the role of the piperazine ring at position 7 in Norfloxacin?
Improves oral absorption, tissue distribution, and metabolic stability
What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?
Increases antimicrobial activity
What is the impact of a single fluorine atom at position 6 in Norfloxacin?
Greatly increases antimicrobial activity and improves penetration into the bacterial cell
What is the drawback of the spectrum of activity of Norfloxacin?
Limited to a small number of gram negative organisms
What is the main advantage of Norfloxacin's piperazine ring at position 7?
Improved oral absorption, tissue distribution, and metabolic stability
Test your knowledge on synthetic antibacterial agents such as quinolones, fluoroquinolones, sulfonamides, and dihydrofolate reductase inhibitors (Trimethoprim). Explore topics like mechanism of action, general structure, therapeutic applications, and more.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
