Podcast
Questions and Answers
What is the benefit of the piperazine ring at position 7 in Norfloxacin?
What is the benefit of the piperazine ring at position 7 in Norfloxacin?
- Improved level and spectrum of activity against P. aeruginosa
- Increased binding to human CNS GABA receptors
- Enhanced metabolic stability
- Improved oral absorption and tissue distribution (correct)
Which position substitution greatly increased the antimicrobial activity of Norfloxacin?
Which position substitution greatly increased the antimicrobial activity of Norfloxacin?
- Carboxylic acid at position 4
- Fluorine atom at position 6 (correct)
- Piperazine ring at position 7
- Nitrogen at position 8 with CH
What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?
What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?
- Decreased binding to human CNS GABA receptors
- Increased antimicrobial activity (correct)
- Enhanced metabolic stability
- Improved spectrum of activity against gram negative organisms
What is the drawback of the piperazine ring at position 7 in Norfloxacin?
What is the drawback of the piperazine ring at position 7 in Norfloxacin?
What is the limitation of the spectrum of activity of Norfloxacin?
What is the limitation of the spectrum of activity of Norfloxacin?
What is the role of a single fluorine atom at position 6 in Norfloxacin?
What is the role of a single fluorine atom at position 6 in Norfloxacin?
What is the drawback of the piperazine ring at position 7 in Norfloxacin?
What is the drawback of the piperazine ring at position 7 in Norfloxacin?
What effect does replacing nitrogen at position 8 with CH have on Norfloxacin?
What effect does replacing nitrogen at position 8 with CH have on Norfloxacin?
What is the main advantage of the piperazine ring at position 7 in Norfloxacin?
What is the main advantage of the piperazine ring at position 7 in Norfloxacin?
Which organisms are particularly affected by the spectrum of activity of Norfloxacin?
Which organisms are particularly affected by the spectrum of activity of Norfloxacin?
What is the role of the piperazine ring at position 7 in Norfloxacin?
What is the role of the piperazine ring at position 7 in Norfloxacin?
What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?
What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?
What is the impact of a single fluorine atom at position 6 in Norfloxacin?
What is the impact of a single fluorine atom at position 6 in Norfloxacin?
What is the drawback of the spectrum of activity of Norfloxacin?
What is the drawback of the spectrum of activity of Norfloxacin?
What is the main advantage of Norfloxacin's piperazine ring at position 7?
What is the main advantage of Norfloxacin's piperazine ring at position 7?
