Synthetic Antibacterial Agents Quiz
15 Questions
3 Views
3.5 Stars

Synthetic Antibacterial Agents Quiz

Created by
@SuitableMookaite

Questions and Answers

What is the benefit of the piperazine ring at position 7 in Norfloxacin?

Improved oral absorption and tissue distribution

Which position substitution greatly increased the antimicrobial activity of Norfloxacin?

Fluorine atom at position 6

What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?

Increased antimicrobial activity

What is the drawback of the piperazine ring at position 7 in Norfloxacin?

<p>Increases binding to human CNS GABA receptors, resulting in CNS side effects</p> Signup and view all the answers

What is the limitation of the spectrum of activity of Norfloxacin?

<p>Limited to a small number of gram negative organisms</p> Signup and view all the answers

What is the role of a single fluorine atom at position 6 in Norfloxacin?

<p>Greatly increased antimicrobial activity and improved penetration into the bacterial cell</p> Signup and view all the answers

What is the drawback of the piperazine ring at position 7 in Norfloxacin?

<p>Increased binding to human CNS GABA receptors, resulting in CNS side effects</p> Signup and view all the answers

What effect does replacing nitrogen at position 8 with CH have on Norfloxacin?

<p>Increased activity</p> Signup and view all the answers

What is the main advantage of the piperazine ring at position 7 in Norfloxacin?

<p>Improved oral absorption, tissue distribution, and metabolic stability</p> Signup and view all the answers

Which organisms are particularly affected by the spectrum of activity of Norfloxacin?

<p>P. aeruginosa</p> Signup and view all the answers

What is the role of the piperazine ring at position 7 in Norfloxacin?

<p>Improves oral absorption, tissue distribution, and metabolic stability</p> Signup and view all the answers

What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?

<p>Increases antimicrobial activity</p> Signup and view all the answers

What is the impact of a single fluorine atom at position 6 in Norfloxacin?

<p>Greatly increases antimicrobial activity and improves penetration into the bacterial cell</p> Signup and view all the answers

What is the drawback of the spectrum of activity of Norfloxacin?

<p>Limited to a small number of gram negative organisms</p> Signup and view all the answers

What is the main advantage of Norfloxacin's piperazine ring at position 7?

<p>Improved oral absorption, tissue distribution, and metabolic stability</p> Signup and view all the answers

Use Quizgecko on...
Browser
Browser