Synthetic Antibacterial Agents Quiz
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Questions and Answers

What is the benefit of the piperazine ring at position 7 in Norfloxacin?

  • Improved level and spectrum of activity against P. aeruginosa
  • Increased binding to human CNS GABA receptors
  • Enhanced metabolic stability
  • Improved oral absorption and tissue distribution (correct)

    • Which position substitution greatly increased the antimicrobial activity of Norfloxacin?

  • Carboxylic acid at position 4
  • Fluorine atom at position 6 (correct)
  • Piperazine ring at position 7
  • Nitrogen at position 8 with CH

    • What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?

  • Decreased binding to human CNS GABA receptors
  • Increased antimicrobial activity (correct)
  • Enhanced metabolic stability
  • Improved spectrum of activity against gram negative organisms

    • What is the drawback of the piperazine ring at position 7 in Norfloxacin?

    <p>Increases binding to human CNS GABA receptors, resulting in CNS side effects</p> Signup and view all the answers

    What is the limitation of the spectrum of activity of Norfloxacin?

    <p>Limited to a small number of gram negative organisms</p> Signup and view all the answers

    What is the role of a single fluorine atom at position 6 in Norfloxacin?

    <p>Greatly increased antimicrobial activity and improved penetration into the bacterial cell</p> Signup and view all the answers

    What is the drawback of the piperazine ring at position 7 in Norfloxacin?

    <p>Increased binding to human CNS GABA receptors, resulting in CNS side effects</p> Signup and view all the answers

    What effect does replacing nitrogen at position 8 with CH have on Norfloxacin?

    <p>Increased activity</p> Signup and view all the answers

    What is the main advantage of the piperazine ring at position 7 in Norfloxacin?

    <p>Improved oral absorption, tissue distribution, and metabolic stability</p> Signup and view all the answers

    Which organisms are particularly affected by the spectrum of activity of Norfloxacin?

    <p>P. aeruginosa</p> Signup and view all the answers

    What is the role of the piperazine ring at position 7 in Norfloxacin?

    <p>Improves oral absorption, tissue distribution, and metabolic stability</p> Signup and view all the answers

    What is the effect of replacing nitrogen at position 8 with CH in Norfloxacin?

    <p>Increases antimicrobial activity</p> Signup and view all the answers

    What is the impact of a single fluorine atom at position 6 in Norfloxacin?

    <p>Greatly increases antimicrobial activity and improves penetration into the bacterial cell</p> Signup and view all the answers

    What is the drawback of the spectrum of activity of Norfloxacin?

    <p>Limited to a small number of gram negative organisms</p> Signup and view all the answers

    What is the main advantage of Norfloxacin's piperazine ring at position 7?

    <p>Improved oral absorption, tissue distribution, and metabolic stability</p> Signup and view all the answers

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