Animal Biotechnology Overview

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Questions and Answers

What is the main purpose of disease models in human health?

  • To create animal models for entertainment
  • To understand disease pathogenesis & therapeutics testing (correct)
  • To discover new diseases
  • To promote drug sales

The Animal Welfare Act strives to promote cruelty in the use of animals in research.

False (B)

Name one technique used in genetic manipulation of animals.

Genome Editing

The _______ Act provides a framework for the responsible care and treatment of animals in research.

<p>Animal Welfare</p> Signup and view all the answers

Match the following biopharmaceutical products with their applications:

<p>Tissues = Transplantation Vaccines = Preventing infections Antibodies = Treating diseases Insulin = Managing diabetes</p> Signup and view all the answers

Which of the following is NOT a technique for genetic manipulation?

<p>Animal Training (D)</p> Signup and view all the answers

Gene-edited pig skin has been used as a temporary wound covering for burn patients.

<p>True (A)</p> Signup and view all the answers

What is one of the proposed uses for gene-edited pig organs?

<p>Transplanting pig corneas into people</p> Signup and view all the answers

What does the 'Freedom from fears and distress' refer to in the context of animal welfare?

<p>Animals should be free from anxiety and mental distress. (C)</p> Signup and view all the answers

The Three Pillars of Animal Welfare include Physical State, Psychological State, and Naturalness.

<p>True (A)</p> Signup and view all the answers

Name the three R's related to ethical animal research practices.

<p>Replacement, Reduction, Refinement</p> Signup and view all the answers

______ emphasizes the importance of an environment that meets animals' mental and emotional needs.

<p>Psychological state</p> Signup and view all the answers

Which of the following is NOT considered one of the Five Freedoms?

<p>Freedom of financial independence (D)</p> Signup and view all the answers

Match the following concepts with their descriptions:

<p>Replacement = Utilizing alternative methods to reduce animal use Reduction = Minimizing the number of animals used in research Refinement = Enhancing animal welfare by minimizing suffering Physical State = Ensuring animals are free from hunger and injury</p> Signup and view all the answers

Animal rights advocates believe that using animals for any purpose is morally wrong.

<p>True (A)</p> Signup and view all the answers

What is the main ethical concern highlighted between Animal Rights and Animal Welfare?

<p>Animal Rights focuses on total liberation of animals, while Animal Welfare allows use of animals if their welfare is ensured.</p> Signup and view all the answers

What is the primary goal of animal biotechnology?

<p>To alter the genetic makeup of animals (A)</p> Signup and view all the answers

Transgenic cows are created to have reduced muscle growth.

<p>False (B)</p> Signup and view all the answers

Name one application of animal biotechnology in agriculture.

<p>Assisted Reproductive Technologies (ART)</p> Signup and view all the answers

The use of __________ techniques helps in preserving the genetics of endangered species.

<p>reproductive</p> Signup and view all the answers

Match the animal biotechnology applications with their respective benefits:

<p>Designer meat = Lab-grown meat for protein demands Optimal Feeding Technologies = Reduced environmental pollution Hypoallergenic milk = A2 beta casein to reduce allergies Disease prevention = New vaccines and diagnostics</p> Signup and view all the answers

Which of the following is a benefit of using probiotics in animal feeding?

<p>Enhanced digestibility and reduced pollution (D)</p> Signup and view all the answers

Optimal Feeding Technologies use microbes to enhance nutrient content and reduce methane production.

<p>True (A)</p> Signup and view all the answers

What is the five freedoms principle in animal welfare?

<p>Principles that address animal welfare needs</p> Signup and view all the answers

Rearing animals in open fields can lead to increased emissions of __________ and methane.

<p>CO2</p> Signup and view all the answers

What is a significant advantage of lab-grown (designer) meat?

<p>It meets the protein demands of a growing population (C)</p> Signup and view all the answers

Flashcards

What is animal biotechnology?

The practice of using genetic engineering to modify the genetic makeup of animals for purposes like improving agricultural practices and medical treatments.

What are some applications of animal biotechnology in agriculture?

Applying animal biotechnology to enhance reproduction and breeding practices in animals.

What is 'Assisted Reproductive Technologies' in animal biotechnology?

Techniques like embryo transfer, microinjection, and sperm/ovum selection, used for controlled breeding and genetic manipulation.

How can animal biotechnology help conserve endangered species?

Using animal biotechnology to preserve endangered species by increasing genetic diversity, leading to healthier populations.

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What are the environmental and conservation benefits of animal biotechnology?

Using biotechnology to improve animal feed efficiency and reduce environmental impact.

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How does animal biotechnology improve animal feeding practices?

Feeding animals optimal diets using probiotics and advanced techniques to improve digestion and reduce pollution.

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How does animal biotechnology enhance animal products?

Improving the nutritional value and safety of animal products by applying animal biotechnology.

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How does animal biotechnology address milk allergies?

Using biotechnology to produce hypoallergenic milk with less potential for allergic reactions to milk proteins in humans.

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How does animal biotechnology contribute to animal wellbeing?

Applying animal biotechnology to improve animal health, prevent diseases, and minimize stress during transport.

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How does animal biotechnology improve humane practices in animal agriculture?

Using animal biotechnology to develop methods for humane slaughter and reducing pain in animals.

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Disease Models

Pre-clinical trials involve testing the safety and effectiveness of new drugs and vaccines in animals before human trials. This helps assess their potential risks and benefits, guiding further research.

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What are Disease Models Used For?

Disease models are valuable tools for understanding disease mechanisms and testing potential treatments in a controlled environment before human trials.

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Bioreactors

Bioreactors are large-scale vessels used to cultivate cells, tissues, and organisms for the production of biopharmaceuticals such as vaccines and therapeutic proteins.

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Genome Editing

Gene editing techniques like CRISPR-Cas9 enable precise modifications to an animal's genome, potentially correcting genetic defects or introducing beneficial traits.

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Cloning

Cloning produces genetically identical copies of an animal, offering a way to study the effects of genetic changes or produce animals with desired traits.

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Animal Welfare Act (AWA)

The Animal Welfare Act (AWA) sets standards for the humane care and use of animals in research, ensuring their welfare and minimizing suffering.

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What Does the AWA Do?

The Animal Welfare Act (AWA) provides a framework for the responsible care and use of animals in research, emphasizing ethical treatment and minimizing harm.

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Bioethics

Bioethics focuses on ethical considerations surrounding the use of biological technologies, including gene editing and cloning of animals. It examines the potential consequences and implications of these technologies for human health and society.

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Freedom from Hunger & Thirst

The freedom from hunger, thirst, and malnutrition. Ensuring access to sufficient, nutritious food and clean water.

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Freedom from Physical Discomfort

The ability to live in a comfortable environment free from physical or thermal discomfort, ensuring appropriate shelter, temperature control, and protection from extreme weather conditions.

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Freedom from Pain & Disease

The freedom from pain, injury, or disease. Ensuring access to regular health checks, prompt medical treatment, and prevention of avoidable suffering.

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Freedom to Express Natural Behaviors

The freedom to engage in natural behaviors, such as foraging, social interaction, and nesting. Ensuring sufficient space, appropriate environment, and opportunities for these behaviors.

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Freedom from Fears & Stress

The freedom from fear, distress, and psychological suffering. Ensuring a safe and secure environment, minimizing stressful situations, and providing opportunities for positive experiences.

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Physical State (Three Pillars)

The capacity of an animal's physiological system to cope with stress. Ensuring they are free from pain, injury, disease, hunger, and thirst.

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Psychological State (Three Pillars)

Emphasizes the importance of an environment that meets their mental and emotional needs. Ensuring they are free from fear, stress, and distress.

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Naturalness (Three Pillars)

Emphasizes the importance of animals living in conditions close to their natural environment. Providing sufficient space for movement, foraging, or roaming.

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Study Notes

Animal Biotechnology

  • Animal biotechnology uses genetic engineering to alter animal genetics for agricultural and medical purposes.

Applications of Animal Biotechnology

Agriculture

  • Reproduction and Breeding: Assisted Reproductive Technologies (ARTs) like embryo transfer, microinjection, sperm and ovum selection are used to preserve endangered species genetics and enhance genetic diversity for healthier populations.
  • Environmental and Conservation Benefits: Optimal feeding technologies use probiotics to reduce chemicals, improve digestibility, and reduce environmental pollution like eutrophication. Microbes are used to process nutrients and reduce methane production in animals. Oil palm frond (OPF) biomass can be converted to biochar and compost to improve soil health and reduce chemical fertilizers.
  • Enhancement of Animal Products: Designer meat (lab-grown meat) offers a scalable solution to meet protein demands. Transgenic cows can have increased muscle growth (double-muscle phenotype). Hypoallergenic milk (A2 beta casein milk) reduces allergic reactions.
  • Animal Wellbeing & Welfare: New vaccines, diagnostics tools, and practices can help farmers manage animal diseases and reduce foodborne pathogens. Animal transportation studies use EEG for detection.

Human Health

  • Disease Models: Pre-clinical trials test medicines and vaccines for safety and efficacy.
  • Biopharmaceutical Products: Bioreactor technology produces tissues, organs, vaccines, antibodies, etc. The transplantation of pig cells, including corneas, into humans is a potential medical application.

Genetic Manipulation in Animals

  • Techniques: Tissue culture, synthetic biology, genome editing, cloning, and bioinformatics are used in genetic manipulation.

Animal Research Regulations

  • Animal Welfare Act (AWA) 2015: This act aims to provide a framework for responsible care, treatment, and use of animals in research, including farm animals, pets, and research facilities. It focuses on preventing cruelty and neglect and promoting animal welfare.

Ethical Concerns in Animal Use in Research

Animal Rights

  • Extreme view: animals should be completely liberated from human use.
  • Animals should not be used for human benefit.

Animal Welfare

  • Compassion and an interest in improving animal wellbeing is important.
  • Using animals is ethically justified if their welfare is taken care of.

Animal Welfare Principles (Three R's)

  • Replacement: Using alternative methods like cell cultures or computer models when possible.
  • Reduction: Using fewer animals in research or collecting more information from a smaller group.
  • Refinement: Using methods that minimize pain and stress to animals or enhance the welfare of the animals used.

Pain and Humane Slaughter

  • Stress markers, pain, and humane slaughter studies are important for specific guidelines on animal welfare.

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