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Animal Pharming and Transgenic Proteins

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Questions and Answers

What is one of the benefits of using plants as bioreactors for the production of therapeutic proteins?

Lower efficiency of agricultural scale-up

Increased risk of genetic diversity

Higher cost of production

Lack of animal pathogenic contaminants (correct)

What is a crucial aspect of efficient plant production systems for recombinant antibodies?

Use of mammary gland-specific promoters

Optimal combination of transgene expression regulatory elements (correct)

Use of transgenic livestock

High cost of production

What is a potential concern regarding food products derived from transgenic animals?

Unknown risk factors (correct)

Lower efficiency of agricultural scale-up

Higher production costs

Lack of genetic diversity

What is a type of protein that can be produced through plant biopharming?

Monoclonal antibodies Signup and view all the answers

What is an advantage of using transgenic crops compared to transgenic animals?

Faster generation times Signup and view all the answers

What is a challenge associated with transgenic animals?

Variable gene expression levels Signup and view all the answers

What is the primary reason for the lack of transgenic-plant-derived pharmaceuticals in commercial production?

Lack of profit incentive for private industry Signup and view all the answers

What is the benefits of expressing antifungal peptides in Arabidopsis plants?

Improved disease resistance from fungi Signup and view all the answers

What is the purpose of using a pressurized hand-held gene gun in plant transformation?

To shoot DNA-coated gold particles into plant tissue Signup and view all the answers

What is an advantage of microparticle bombardment in plant transformation?

Ability to transform recalcitrant species Signup and view all the answers

What is an advantage of co-transformation with multiple transgenes?

Introduction of multiple genes of interest with one selectable marker Signup and view all the answers

What is the use of mice in biomedical research?

Testing of new medical treatments Signup and view all the answers

What is one of the benefits of plant cell cultures in biopharmaceutical production?

Reduced regulatory costs Signup and view all the answers

Which plant cell strains are known for being fast-growing and robust?

Nicotiana tabacum-1 and BY-2 Signup and view all the answers

What is a major limitation of plant cell cultures in biopharmaceutical production?

Low productivity Signup and view all the answers

What is required to increase the efficiency of plant cell cultures in biopharmaceutical production?

A systematic strategy to maximize the efficiency of all stages of the production pipeline Signup and view all the answers

What is the goal for increasing productivity in plant cell cultures?

10-50 fold increase Signup and view all the answers