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Anesthesia and MAC: Understanding Pharmacologic Response

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Anesthesia and MAC: Understanding Pharmacologic Response

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Questions and Answers

What is critical to the pharmacologic response of an anesthetic?

The total pressure of the anesthetic in the breathing circuit

The partial pressure of the anesthetic at the effect site (correct)

The volume percentage of the anesthetic in the ambient air

The concentration of the anesthetic in the inspired gas

What is the unit of measurement for MAC?

volume percent (correct)

mg/mL

atm

mmHg

What is the condition under which MAC is defined?

At 2-atm ambient pressure

At 4-atm ambient pressure

At 3-atm ambient pressure

At 1-atm ambient pressure (correct)

What is the pharmacologic response measured by MAC?

Immobility Signup and view all the answers

What is the relationship between the partial pressure of an anesthetic and its concentration at the effect site?

The partial pressure is directly proportional to the concentration Signup and view all the answers

What is the primary purpose of determining the minimum alveolar concentration (MAC) of an inhaled anesthetic?

To establish the concentration at which 50% of patients do not move in response to a stimulus Signup and view all the answers

What is the standard condition for measuring MAC in human subjects?

Normal body temperature and 1 atm Signup and view all the answers

What is the typical stimulus used in laboratory studies to measure MAC in rodents?

Application of a tail clamp Signup and view all the answers

What is the significance of the 50% immobility threshold in MAC measurement?

It is the concentration at which 50% of subjects do not respond to a stimulus Signup and view all the answers

Who are the researchers credited with describing the concept of MAC?

Eger and colleagues Signup and view all the answers

What is the primary factor driving the rate of inhaled anesthetic uptake and elimination from the alveoli?

Blood solubility of the anesthetic agent Signup and view all the answers

Which of the following statements is true about the relationship between blood solubility and the rate of inhaled anesthetic uptake and elimination?

Less soluble agents have faster uptake and elimination Signup and view all the answers

What is the primary determinant of the pharmacokinetics of inhaled anesthetic agents?

Physical properties of the anesthetic agent Signup and view all the answers

Which of the following factors does not affect the rate of inhaled anesthetic uptake and elimination from the alveoli?

MAC of the anesthetic agent Signup and view all the answers

What is the effect of increased blood solubility on the rate of inhaled anesthetic uptake and elimination from the alveoli?

It decreases the rate of uptake and elimination Signup and view all the answers