Anesthesia and MAC: Understanding Pharmacologic Response
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Questions and Answers

What is critical to the pharmacologic response of an anesthetic?

  • The total pressure of the anesthetic in the breathing circuit
  • The partial pressure of the anesthetic at the effect site (correct)
  • The volume percentage of the anesthetic in the ambient air
  • The concentration of the anesthetic in the inspired gas

What is the unit of measurement for MAC?

  • volume percent (correct)
  • mg/mL
  • atm
  • mmHg

What is the condition under which MAC is defined?

  • At 2-atm ambient pressure
  • At 4-atm ambient pressure
  • At 3-atm ambient pressure
  • At 1-atm ambient pressure (correct)

What is the pharmacologic response measured by MAC?

<p>Immobility (B)</p> Signup and view all the answers

What is the relationship between the partial pressure of an anesthetic and its concentration at the effect site?

<p>The partial pressure is directly proportional to the concentration (D)</p> Signup and view all the answers

What is the primary purpose of determining the minimum alveolar concentration (MAC) of an inhaled anesthetic?

<p>To establish the concentration at which 50% of patients do not move in response to a stimulus (C)</p> Signup and view all the answers

What is the standard condition for measuring MAC in human subjects?

<p>Normal body temperature and 1 atm (C)</p> Signup and view all the answers

What is the typical stimulus used in laboratory studies to measure MAC in rodents?

<p>Application of a tail clamp (A)</p> Signup and view all the answers

What is the significance of the 50% immobility threshold in MAC measurement?

<p>It is the concentration at which 50% of subjects do not respond to a stimulus (B)</p> Signup and view all the answers

Who are the researchers credited with describing the concept of MAC?

<p>Eger and colleagues (B)</p> Signup and view all the answers

What is the primary factor driving the rate of inhaled anesthetic uptake and elimination from the alveoli?

<p>Blood solubility of the anesthetic agent (A)</p> Signup and view all the answers

Which of the following statements is true about the relationship between blood solubility and the rate of inhaled anesthetic uptake and elimination?

<p>Less soluble agents have faster uptake and elimination (D)</p> Signup and view all the answers

What is the primary determinant of the pharmacokinetics of inhaled anesthetic agents?

<p>Physical properties of the anesthetic agent (D)</p> Signup and view all the answers

Which of the following factors does not affect the rate of inhaled anesthetic uptake and elimination from the alveoli?

<p>MAC of the anesthetic agent (D)</p> Signup and view all the answers

What is the effect of increased blood solubility on the rate of inhaled anesthetic uptake and elimination from the alveoli?

<p>It decreases the rate of uptake and elimination (D)</p> Signup and view all the answers

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