15 Questions
What is critical to the pharmacologic response of an anesthetic?
The partial pressure of the anesthetic at the effect site
What is the unit of measurement for MAC?
volume percent
What is the condition under which MAC is defined?
At 1-atm ambient pressure
What is the pharmacologic response measured by MAC?
Immobility
What is the relationship between the partial pressure of an anesthetic and its concentration at the effect site?
The partial pressure is directly proportional to the concentration
What is the primary purpose of determining the minimum alveolar concentration (MAC) of an inhaled anesthetic?
To establish the concentration at which 50% of patients do not move in response to a stimulus
What is the standard condition for measuring MAC in human subjects?
Normal body temperature and 1 atm
What is the typical stimulus used in laboratory studies to measure MAC in rodents?
Application of a tail clamp
What is the significance of the 50% immobility threshold in MAC measurement?
It is the concentration at which 50% of subjects do not respond to a stimulus
Who are the researchers credited with describing the concept of MAC?
Eger and colleagues
What is the primary factor driving the rate of inhaled anesthetic uptake and elimination from the alveoli?
Blood solubility of the anesthetic agent
Which of the following statements is true about the relationship between blood solubility and the rate of inhaled anesthetic uptake and elimination?
Less soluble agents have faster uptake and elimination
What is the primary determinant of the pharmacokinetics of inhaled anesthetic agents?
Physical properties of the anesthetic agent
Which of the following factors does not affect the rate of inhaled anesthetic uptake and elimination from the alveoli?
MAC of the anesthetic agent
What is the effect of increased blood solubility on the rate of inhaled anesthetic uptake and elimination from the alveoli?
It decreases the rate of uptake and elimination
Learn about the crucial role of partial pressure and concentration at the effect site in determining the pharmacologic response to anesthesia, specifically in relation to MAC. Test your knowledge on the key factors influencing immobility.
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