Podcast
Questions and Answers
What is the recommended HPLC level of itraconazole associated with toxicity?
What is the recommended HPLC level of itraconazole associated with toxicity?
- 10 Mcg/mL
- 2-3 Mcg/mL (correct)
- 1 Mog/mL
- 6 Mcg/mL
Why does itraconazole always require Therapeutic Drug Monitoring (TDM)?
Why does itraconazole always require Therapeutic Drug Monitoring (TDM)?
- Due to its high bioavailability
- Because of pharmacokinetic (PK) variability (correct)
- To ensure patient compliance
- To avoid drug interactions
How long should you wait before checking itraconazole levels after the dose?
How long should you wait before checking itraconazole levels after the dose?
- 1 hour (correct)
- 30 minutes
- 4 hours
- 6 hours
What is recommended to fix a subtherapeutic level of itraconazole?
What is recommended to fix a subtherapeutic level of itraconazole?
How does Amphotericin B work?
How does Amphotericin B work?
How is voriconazole dosed?
How is voriconazole dosed?
What is the purpose of 5-flucytosine in combination with Amphotericin B?
What is the purpose of 5-flucytosine in combination with Amphotericin B?
Which formulation of voriconazole is available for administration?
Which formulation of voriconazole is available for administration?
Why is Amphotericin B formulated with sodium deoxycholate or phospholipids?
Why is Amphotericin B formulated with sodium deoxycholate or phospholipids?
What mammalian cells do polyenes like Amphotericin B target?
What mammalian cells do polyenes like Amphotericin B target?
What is the MOA of Griseofulvin?
What is the MOA of Griseofulvin?
What types of rings can azoles contain?
What types of rings can azoles contain?
What is a counseling pearl needed for itraconazole capsules?
What is a counseling pearl needed for itraconazole capsules?
What pharmacokinetic factor leads to the need for Therapeutic Drug Monitoring (TDM) in itraconazole?
What pharmacokinetic factor leads to the need for Therapeutic Drug Monitoring (TDM) in itraconazole?
Itraconazole is metabolized by ______________, inhibits ______________, and ____________.
Itraconazole is metabolized by ______________, inhibits ______________, and ____________.
What does itraconazole metabolize into?
What does itraconazole metabolize into?
What happens when itraconazole interacts with CYP3A4 inducers?
What happens when itraconazole interacts with CYP3A4 inducers?
Higher levels of itraconazole are associated with _____________ clinical outcomes.
Higher levels of itraconazole are associated with _____________ clinical outcomes.
What levels of Posaconazole have been associated with toxicity?
What levels of Posaconazole have been associated with toxicity?
When should therapeutic drug monitoring (TDM) be performed for Posaconazole?
When should therapeutic drug monitoring (TDM) be performed for Posaconazole?
Where should levels be checked for Posaconazole?
Where should levels be checked for Posaconazole?
When are peak concentrations for vancomycin typically drawn?
When are peak concentrations for vancomycin typically drawn?
What is the purpose of AUC-based monitoring for vancomycin?
What is the purpose of AUC-based monitoring for vancomycin?
Why is AUC-based monitoring becoming more popular for vancomycin?
Why is AUC-based monitoring becoming more popular for vancomycin?
What is the recommended trough-based vancomycin dosing typically based on?
What is the recommended trough-based vancomycin dosing typically based on?
Which type of infections are excluded from vancomycin AUC monitoring due to their unpredictable kinetics?
Which type of infections are excluded from vancomycin AUC monitoring due to their unpredictable kinetics?
What level of vancomycin AUC has been associated with increased nephrotoxicity?
What level of vancomycin AUC has been associated with increased nephrotoxicity?
For which bacteria is vancomycin typically not considered susceptible?
For which bacteria is vancomycin typically not considered susceptible?
How is the loading dose of vancomycin calculated?
How is the loading dose of vancomycin calculated?
What is a potential adverse effect related to vancomycin infusion?
What is a potential adverse effect related to vancomycin infusion?
Flashcards are hidden until you start studying
