Amphotericin B

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Questions and Answers

Amphotericin B is absorbed:

  • Efficiently by the GI tract, hence oral and IV therapy can be used for systemic infection
  • Poorly by the GI tract, hence oral therapy cannot be used for systemic infection and must be given IV (correct)
  • Poorly by the GI tract and can be given orally and IV for systemic infection
  • Poorly by the GI tract and must be given IM

Amphotericin B is:

  • Known to be quickly metabolized with moderate renal excretion
  • Known to be slowly metabolized and removed from the body with no renal excretion
  • Unknown if metabolized or ultimately removed from the body, with minimal renal excretion (correct)
  • Is not metabolized and thus leaves the body by full renal excretion

Amphotericin B is eliminated:

  • Quickly, within 48-72 hours
  • Slowly, up to one month
  • Slowly, up to one year (correct)
  • Within 1-2 weeks

Dose or frequency reduction for Amphotericin B should be discussed in patients with:

<p>Renal impairment (D)</p> Signup and view all the answers

Minimizing nephrotoxicity with Amphotericin B can be done by:

<p>Infusing one liter of normal saline on days the drug is administered (A)</p> Signup and view all the answers

Flashcards

Amphotericin B Absorption

Amphotericin B is not absorbed well by the digestive system.

Amphotericin B Administration

Amphotericin B is given intravenously for systemic infections because it's poorly absorbed orally.

Amphotericin B Metabolism

It's unknown how Amphotericin B is broken down or removed from the body.

Amphotericin B Elimination

Amphotericin B stays in the body for a long time - up to a year.

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Amphotericin B Dosage Adjustment

Patients with kidney problems may need a lower dose or less frequent doses of Amphotericin B.

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