Questions and Answers
What is the mechanism of action of amphotericin B?
Amphotericin B binds to ergosterol in the plasma membranes of sensitive fungal cells, disrupting membrane function and leading to cell death.
Which fungi is amphotericin B effective against?
Amphotericin B is effective against a wide range of fungi, including Candida albicans, Histoplasma capsulatum, Cryptococcus neoformans, Coccidioides immitis, Blastomyces dermatitidis, and many strains of Aspergillus.
How is amphotericin B administered?
Amphotericin B is administered by slow, intravenous (IV) infusion.
Name three adverse effects associated with the use of amphotericin B.
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