Amphotericin B Mechanism of Action

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What is the mechanism of action of amphotericin B?

Amphotericin B binds to ergosterol in the plasma membranes of sensitive fungal cells, disrupting membrane function and leading to cell death.

Which fungi is amphotericin B effective against?

Amphotericin B is effective against a wide range of fungi, including Candida albicans, Histoplasma capsulatum, Cryptococcus neoformans, Coccidioides immitis, Blastomyces dermatitidis, and many strains of Aspergillus.

How is amphotericin B administered?

Amphotericin B is administered by slow, intravenous (IV) infusion.

Name three adverse effects associated with the use of amphotericin B.

a. Renal impairment b. Hypotension c. Anemia

Test your knowledge of the mechanism of action of Amphotericin B, a polyene macrolide antibiotic used in the treatment of systemic mycoses. Learn about how it disrupts membrane function in sensitive fungal cells by binding to ergosterol.

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