Amino Acids Metabolism
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Questions and Answers

Which disease is characterized by protein deficiency with adequate energy intake in children?

  • Marasmus
  • Fatty liver
  • Kwashiorkor (correct)
  • Oedema

At what age does Marasmus commonly occur?

  • Between 3 and 6 months
  • Under 1 year
  • Above 3 years (correct)
  • Between 6 months and 3 years

Which disease is associated with the preservation of subcutaneous fat?

  • Fatty liver
  • Marasmus
  • Kwashiorkor (correct)
  • Oedema

In which disease is fatty liver enlarged?

<p>Kwashiorkor (A)</p> Signup and view all the answers

Which classification of amino acids is based on the polarity of side chains?

<p>Chemical Classification (D)</p> Signup and view all the answers

What is a common feature of both Kwashiorkor and Marasmus diseases?

<p>Presence of oedema (B)</p> Signup and view all the answers

What is the primary pathway where extracellular, membrane-associated, and long-lived intracellular proteins are degraded?

<p>Lysosomes (A)</p> Signup and view all the answers

What percentage of total body protein do humans turn over daily?

<p>1% to 2% (D)</p> Signup and view all the answers

Which organelle contains proteases for proteins, lipases for lipids, and many other hydrolases involved in non-specific protein degradation?

<p>Lysosomes (A)</p> Signup and view all the answers

What is the term used to express the relative susceptibility of a protein to degradation?

<p>Half-life (t1/2) (C)</p> Signup and view all the answers

In which processes do increased lysosomal activity play a significant role?

<p>Disuse atrophy of muscles and regression of the uterus after childbirth (C)</p> Signup and view all the answers

What percentage of amino acids liberated by protein degradation are reutilized?

<p>75% (B)</p> Signup and view all the answers

What is the primary enzyme involved in proteolytic digestion in the stomach?

<p>Pepsin (B)</p> Signup and view all the answers

During which situations must protein synthesis exceed protein degradation?

<p>Growth, pregnancy, and illness recovery (B)</p> Signup and view all the answers

Which enzyme cleaves peptide chains mainly at the carboxyl side of lysine or arginine?

<p>Trypsin (C)</p> Signup and view all the answers

What is the function of elastase in protein digestion?

<p>Hydrolysis of large hydrophobic residues (D)</p> Signup and view all the answers

What is the optimal pH for pepsin, the primary enzyme in stomach digestion?

<p>2 (highly acidic) (C)</p> Signup and view all the answers

Which type of bonds does chymotrypsin preferentially hydrolyze in protein digestion?

<p>Involving tyrosine, phenylalanine, and tryptophan (D)</p> Signup and view all the answers

What is the main cellular mechanism responsible for the degradation of regulatory proteins with short half-lives and abnormal proteins?

<p>Ubiquitin-Proteasome System (B)</p> Signup and view all the answers

Which molecule is required for the attachment of Ub molecules to the target protein during ubiquitination?

<p>ATP (C)</p> Signup and view all the answers

How does the number of Ub molecules attached to a protein affect its degradation rate?

<p>Increases degradation rate (A)</p> Signup and view all the answers

What type of bond is formed between the carboxyl terminal of Ub and lysyl residues in the target protein during ubiquitination?

<p>Isopeptide bond (C)</p> Signup and view all the answers

Which amino acid residues at the amino terminus of a protein affect its rate of ubiquitination?

<p>Methionine (Met) or Serine (Ser) (D)</p> Signup and view all the answers

Where does the subsequent degradation of Ub-tagged proteins take place?

<p>Proteasome (C)</p> Signup and view all the answers

Which amino acid is primarily extracted by the liver in the postabsorptive state?

<p>Alanine (D)</p> Signup and view all the answers

Which amino acid serves as a source of ammonia for excretion by the kidney?

<p>Glutamine (B)</p> Signup and view all the answers

Which amino acid is predominantly taken up by the brain from muscle in the postabsorptive state?

<p>Valine (B)</p> Signup and view all the answers

In the fed state after a protein-rich meal, which tissues release amino acids?

<p>Splanchnic tissues (B)</p> Signup and view all the answers

Which organ provides a major source of serine for uptake by peripheral tissues in humans?

<p>Kidney (B)</p> Signup and view all the answers

What is the function of ubiquitin in eukaryotic cells?

<p>It differentiates between functional and intracellular proteins for degradation (C)</p> Signup and view all the answers

Which amino acid residues at the amino terminus accelerate the ubiquitination of a protein?

<p>Aspartate (D)</p> Signup and view all the answers

What macromolecule is responsible for the degradation of Ub-tagged proteins in eukaryotic cells?

<p>Proteasomes (C)</p> Signup and view all the answers

What is the energy requirement for the addition of Ub molecules to proteins during ubiquitination?

<p>ATP hydrolysis (B)</p> Signup and view all the answers

Which type of residues at the amino terminus of a protein retard its ubiquitination?

<p>Methionine (A)</p> Signup and view all the answers

Which cellular organelle is responsible for the degradation of regulatory proteins with short half-lives?

<p>Proteasomes (B)</p> Signup and view all the answers

What determines the rate of degradation of a protein with Ub molecules attached to it?

<p>Number of Ub molecules attached (B)</p> Signup and view all the answers

In which cellular compartment does the degradation of Ub-tagged proteins mainly occur?

<p>Cytosol (C)</p> Signup and view all the answers

Which enzyme is responsible for adding Ub molecules to proteins during ubiquitination?

<p>Ubiquitin ligase (D)</p> Signup and view all the answers

What is the role of lysosomal enzymes in chronic inflammatory diseases such as rheumatoid arthritis?

<p>Attack surrounding tissues (C)</p> Signup and view all the answers

What determines the rate of degradation of normal proteins with comparable functions?

<p>N-terminal residue (B)</p> Signup and view all the answers

Which amino acid residues at the amino terminus of a protein accelerate its ubiquitination?

<p>Arginine (Arg) and Aspartate (Asp) (A)</p> Signup and view all the answers

What is the function of PEST sequences in proteins?

<p>Accelerate ubiquitination (A)</p> Signup and view all the answers

Where does the degradation of polyubiquitinated proteins occur?

<p>Proteasome (C)</p> Signup and view all the answers

Which type of protein degradation occurs for abnormal proteins?

<p>Rapid degradation (A)</p> Signup and view all the answers

What role do enzymes at important metabolic control points play in protein degradation?

<p>Accelerate protein degradation (C)</p> Signup and view all the answers

What is the primary reason for the net balance of circulating plasma amino acids between meals?

<p>Utilization by various tissues (D)</p> Signup and view all the answers

Which residues in the N-terminal region of a protein retard its ubiquitination?

<p>(M)ethionine and (S)erine residues (B)</p> Signup and view all the answers

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