Podcast
Questions and Answers
What is the primary role of alanine aminotransferase (ALT)?
What is the primary role of alanine aminotransferase (ALT)?
Which coenzyme is essential for the function of both ALT and AST?
Which coenzyme is essential for the function of both ALT and AST?
Which tissue has the highest concentration of alanine aminotransferase (ALT)?
Which tissue has the highest concentration of alanine aminotransferase (ALT)?
What is the older terminology for aspartate aminotransferase (AST)?
What is the older terminology for aspartate aminotransferase (AST)?
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Which reaction does aspartate aminotransferase (AST) catalyze?
Which reaction does aspartate aminotransferase (AST) catalyze?
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Why is ALT considered the more liver-specific enzyme of the transferases?
Why is ALT considered the more liver-specific enzyme of the transferases?
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Study Notes
Alanine Transaminase (ALT) or (GPT)
- ALT is a transferase with enzymatic activity similar to AST.
- It catalyzes the transfer of an amino group from alanine to α-ketoglutarate, forming glutamate and pyruvate.
- The older terminology for ALT is serum glutamic-pyruvic transaminase (SGPT, or GPT).
- Pyridoxal phosphate acts as the coenzyme in the transferase reaction.
Tissue Source
- ALT is distributed in many tissues, but has comparatively high concentrations in the liver.
- It is considered the more liver-specific enzyme of the transferases.
Aspartate Transaminase (AST) or (GOT)
- AST is an enzyme belonging to the class of transferases and is commonly referred to as a transaminase.
- It is involved in the transfer of an amino group between aspartate and α-keto acids.
- The older terminology for AST is serum glutamic-oxaloacetic transaminase (SGOT, or GOT).
- Pyridoxal phosphate functions as a coenzyme in the AST reaction.
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Description
Learn about the enzyme Alanine Transaminase (ALT) also known as serum glutamic-pyruvic transaminase (GPT), its function, and tissue distribution. Understand the enzymatic activity and reaction involving pyridoxal phosphate as the coenzyme.
