Glucogenic Amino Acids Pathway: Alanine to Pyruvate
75 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which process involves converting other carbohydrates to glucose, but is not considered as gluconeogenesis?

  • Glycogenolysis
  • Gluconeogenesis
  • Glycolysis
  • Glycogenesis (correct)

What is the primary substrate used in gluconeogenesis?

  • Proteins
  • Nucleic acids
  • Carbohydrates (correct)
  • Fats

Which process involves breaking down glycogen to release glucose into the bloodstream?

  • Glycogenolysis (correct)
  • Ketogenesis
  • Gluconeogenesis
  • Glycolysis

In the context provided, what process specifically refers to the conversion of non-carbohydrate sources to glucose?

<p>Gluconeogenesis (B)</p> Signup and view all the answers

Which metabolic pathway involves the breakdown of glucose into pyruvate?

<p>Glycolysis (B)</p> Signup and view all the answers

What is the precursor for entering the glucogenic pathway?

<p>Alanine (A)</p> Signup and view all the answers

What transformation does alanine undergo to enter the glucogenic pathway?

<p>Transamination (B)</p> Signup and view all the answers

Which keto acid does alanine become after transamination?

<p>Pyruvate (C)</p> Signup and view all the answers

What is the easiest amino acid to enter into the glucogenic pathway?

<p>Alanine (A)</p> Signup and view all the answers

Which metabolic pathway does alanine enter after transamination?

<p>Gluconeogenesis (C)</p> Signup and view all the answers

What is the first step in the process described?

<p>High concentration (B)</p> Signup and view all the answers

What does the compound attach to in the process?

<p>GPCR (B)</p> Signup and view all the answers

Which step results in the activation of cAMP synthesis?

<p>Attaching to GPCR (A)</p> Signup and view all the answers

What is the final step in the described process?

<p>Protein kinase A attachment (C)</p> Signup and view all the answers

Which component is responsible for activating protein kinase A in the process?

<p>cAMP synthesis (C)</p> Signup and view all the answers

What is the main difference between the enzymes in glycolysis and gluconeogenesis?

<p>Enzymes in glycolysis have a positive ΔG in phosphorylation, while enzymes in gluconeogenesis have a negative ΔG. (D)</p> Signup and view all the answers

Where does the process described occur, according to the text?

<p>Kidney and liver (C)</p> Signup and view all the answers

What molecule provides both energy and a phosphate group for the phosphorylation of glucose in glycolysis?

<p>ATP (D)</p> Signup and view all the answers

Why is it necessary to couple the phosphorylation in glycolysis with ATP hydrolysis?

<p>To generate a negative net ΔG (D)</p> Signup and view all the answers

Which of the following organs does NOT play a role in the process described?

<p>Pancreas (B)</p> Signup and view all the answers

What are the products when 1,3 bisphosphoglycerate is converted to glyceraldehyde 3-P during gluconeogenesis?

<p>Inorganic phosphate, 2 NAD+ (A)</p> Signup and view all the answers

What happens when 3-phosphoglycerate is converted to 1,3 bis-phosphoglycerate in gluconeogenesis?

<p>2 ATP are hydrolyzed to 2 ADP (B)</p> Signup and view all the answers

Which molecules are oxidized into NAD+ during gluconeogenesis?

<p>NADH (B)</p> Signup and view all the answers

What role does inorganic phosphate play in the conversion of 1,3 bisphosphoglycerate to glyceraldehyde 3-P?

<p>It is released (C)</p> Signup and view all the answers

How many ATP molecules are hydrolyzed to ADP during the conversion of 3-phosphoglycerate to 1,3 bis-phosphoglycerate?

<p>2 ATP (C)</p> Signup and view all the answers

Where does gluconeogenesis occur?

<p>Kidneys (B)</p> Signup and view all the answers

Which component is NOT involved in gluconeogenesis?

<p>Heart (B)</p> Signup and view all the answers

When does gluconeogenesis primarily take place?

<p>During fasting or starvation (C)</p> Signup and view all the answers

Which of the following is NOT a site where gluconeogenesis occurs?

<p>Skeletal muscle (B)</p> Signup and view all the answers

Besides the liver and kidneys, where else can gluconeogenesis occur?

<p>Spleen (A)</p> Signup and view all the answers

What happens to glycerol once it is released from the adipocytes?

<p>It travels through the bloodstream on albumin (A)</p> Signup and view all the answers

How are fatty acids transported in the bloodstream?

<p>Bound to lipoproteins (D)</p> Signup and view all the answers

What do different cell types primarily use fatty acids for?

<p>Energy production (B)</p> Signup and view all the answers

Which protein serves as a carrier for glycerol in the bloodstream?

<p>Albumin (C)</p> Signup and view all the answers

How is glycerol related to the breakdown of fatty acids?

<p>Glycerol is a byproduct of fatty acid breakdown (B)</p> Signup and view all the answers

Which process involves the synthesis of glucose from non-carbohydrate sources?

<p>Gluconeogenesis (D)</p> Signup and view all the answers

What is the primary role of gluconeogenesis in metabolism?

<p>Converting pyruvate into glucose (B)</p> Signup and view all the answers

What is the fate of alanine after undergoing transamination?

<p>Converted into glyceraldehyde 3-phosphate for gluconeogenesis (A)</p> Signup and view all the answers

Which organ primarily regulates the process of gluconeogenesis in the body?

<p>Liver (D)</p> Signup and view all the answers

What is the key purpose of gluconeogenesis in terms of maintaining blood glucose levels?

<p>To stabilize blood glucose levels during fasting or starvation (D)</p> Signup and view all the answers

What is the function of Glucose 6-phosphatase in relation to Hexokinase/Glucokinase?

<p>Catalyzes the breakdown of glucose 6-phosphate (A)</p> Signup and view all the answers

Where does Glucose 6-phosphatase function in the cell?

<p>Endoplasmic reticulum (A)</p> Signup and view all the answers

Which transporter is responsible for transporting glucose from the endoplasmic reticulum to the cytosol in hepatocytes/kidney cells?

<p>Glute 7 transporter (B)</p> Signup and view all the answers

After exiting the cell, how does glucose reach the bloodstream?

<p>Through other types of glucose transporters (B)</p> Signup and view all the answers

What is the role of Hexokinase/Glucokinase in this process?

<p>Converts glucose to glucose 6-phosphate in the cytosol (D)</p> Signup and view all the answers

Why is acetyl CoA specifically mentioned as the activator for pyruvate carboxylase?

<p>Acetyl CoA is produced in large amounts during fatty acid degradation in fasting state (A)</p> Signup and view all the answers

What happens to the excess acetyl CoA that cannot be utilized by the Krebs cycle in fasting conditions?

<p>It accumulates and activates pyruvate carboxylase (A)</p> Signup and view all the answers

In the context provided, what role does pyruvate carboxylase play in gluconeogenesis?

<p>It catalyzes the conversion of pyruvate to oxaloacetate (D)</p> Signup and view all the answers

What metabolic state of the cell triggers the activation of pyruvate carboxylase by acetyl CoA?

<p>Fasting state (D)</p> Signup and view all the answers

Why does the cell require the activation of pyruvate carboxylase during fasting?

<p>To generate glucose from non-carbohydrate sources like fatty acids (B)</p> Signup and view all the answers

Why is ATP not used in the dephosphorylation of Glucose 6-phosphate?

<p>The phosphatase enzyme has a negative ΔG. (A)</p> Signup and view all the answers

What drives the dephosphorylation of Glucose 6-phosphate by the phosphatase enzyme?

<p>Negative ΔG (C)</p> Signup and view all the answers

In the context of the text, what is the significance of the negative ΔG in the dephosphorylation reaction?

<p>It facilitates the conversion of Glucose 6-phosphate without ATP. (B)</p> Signup and view all the answers

Why does dephosphorylation of Glucose 6-phosphate not utilize ATP despite being an energy-requiring process?

<p>Presence of a negative ΔG (A)</p> Signup and view all the answers

What metabolic condition would likely alter the need for ATP in the dephosphorylation of Glucose 6-phosphate?

<p>Starvation state (C)</p> Signup and view all the answers

What is the enzyme responsible for converting Phosphoenolpyruvate to pyruvate in the final step of glycolysis?

<p>Phosphofructokinase (A)</p> Signup and view all the answers

In gluconeogenesis, which enzyme catalyzes the conversion of pyruvate to Phosphoenolpyruvate, the reverse reaction of the last step in glycolysis?

<p>Hexokinase (C)</p> Signup and view all the answers

Which molecule serves as the precursor for the synthesis of Phosphoenolpyruvate from pyruvate in gluconeogenesis?

<p>Malonyl-CoA (A)</p> Signup and view all the answers

Which of the following enzymes is NOT directly involved in the conversion of Phosphoenolpyruvate to pyruvate in glycolysis or its reverse reaction in gluconeogenesis?

<p>Fructose-1,6-bisphosphatase (D)</p> Signup and view all the answers

Which of the following statements regarding Pyruvate kinase is INCORRECT in the context of glycolysis and gluconeogenesis?

<p>Pyruvate kinase is activated by fructose-6-phosphate in gluconeogenesis. (B)</p> Signup and view all the answers

What is the initial reaction that takes place in mitochondria involving pyruvate?

<p>Conversion of pyruvate to oxaloacetate by pyruvate carboxylase (C)</p> Signup and view all the answers

Why is pyruvate carboxylase activation essential during fasting?

<p>To convert excess acetyl CoA into pyruvate for energy production (B)</p> Signup and view all the answers

What is the role of oxaloacetate in the context of pyruvate metabolism?

<p>It reacts with acetyl-CoA to form citrate in the TCA cycle (D)</p> Signup and view all the answers

Which enzyme is responsible for catalyzing the conversion of pyruvate to oxaloacetate in the mitochondria?

<p>Pyruvate carboxylase (B)</p> Signup and view all the answers

Which substance is produced as a result of the reaction catalyzed by pyruvate carboxylase?

<p>Oxaloacetate (A)</p> Signup and view all the answers

What is the fate of inorganic phosphate in the conversion of 1,3 bisphosphoglycerate to glyceraldehyde 3-P during gluconeogenesis?

<p>It is consumed by the reaction (B)</p> Signup and view all the answers

What is the ultimate outcome of the ATP molecules hydrolyzed to ADP during the conversion of 3-phosphoglycerate to 1,3 bisphosphoglycerate in gluconeogenesis?

<p>They are used for cellular respiration (C)</p> Signup and view all the answers

What is the function of 1,3 bisphosphoglycerate in the context of gluconeogenesis?

<p>Serves as a carrier of high-energy phosphate bonds (A)</p> Signup and view all the answers

How does NADH contribute to the conversion of 1,3 bisphosphoglycerate to glyceraldehyde 3-P?

<p>It provides electrons to reduce NAD+ (D)</p> Signup and view all the answers

What is the primary role of NAD+ in the context of gluconeogenesis?

<p>To carry electrons from NADH (A)</p> Signup and view all the answers

What is the primary function of Glucose 6-phosphatase in gluconeogenesis?

<p>Converting glucose 6-phosphate back to glucose (D)</p> Signup and view all the answers

Which type of transporters are responsible for facilitating the exit of glucose from hepatocytes/kidney cells in gluconeogenesis?

<p>Fructose transporters (C)</p> Signup and view all the answers

What is the enzyme responsible for transporting glucose from the endoplasmic reticulum to the cytosol in hepatocytes/kidney cells during gluconeogenesis?

<p>Glute 7 (A)</p> Signup and view all the answers

What is the main difference between Glucose 6-phosphatase and Hexokinase/Glucokinase in terms of their roles in glucose metabolism?

<p>Glucose 6-phosphatase converts glucose back to glucose 6-phosphate while Hexokinase/Glucokinase phosphorylate glucose (A)</p> Signup and view all the answers

In the context of gluconeogenesis, what is the primary role of Glute 7 existing on the ER membrane?

<p>Facilitating the entry of glucose into the cell (C)</p> Signup and view all the answers

More Like This

Use Quizgecko on...
Browser
Browser