Clinical Biochemistry Department of Pathological Analysis - Alanine Aminotransferase (ALT)

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30 Questions

What is the leading cause of intrahepatic cholestasis?

Cirrhosis

What is the usual cause of extrahepatic obstruction?

Mechanical obstruction of common bile duct

Which liver condition is indicated by high titers of antimitochondrial antibody?

Cirrhosis

What is the main cause of portal hypertension in chronic liver diseases?

Hepatic fibrosis

Which is the most common cause of cirrhosis?

Chronic excess alcohol ingestion

Why are there no good biochemical indicators of cirrhosis in the early and stable period?

The disease progression is slow and asymptomatic

Which type of liver injury results from acute massive liver cell necrosis?

Acute Hepatocellular Injury

What clinical manifestation is characteristic of acute liver failure?

Hypoglycemia

What term describes the accumulation of substances normally excreted in bile in the bloodstream?

Cholestasis

Which substance is NOT mentioned as being elevated in acute liver failure?

BUN

Which of the following is a potential outcome of acute liver disease?

Resolution

Which type of liver disease may result from chronic alcohol consumption?

Fatty Liver

What condition may present with a mild increase in Alanine Aminotransferase (ALT) levels?

Hepatocellular disease

Which health issue is not typically associated with elevated Aspartate Aminotransferase (AST) levels?

Chronic kidney disease

In which condition would the ALT/AST ratio typically be greater than 1.0?

Alcoholic liver disease

What is a significant source of alkaline phosphatase aside from the liver?

Bone

Which condition would likely have both Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) elevated to a similar degree?

Viral hepatitis

Which liver condition would likely have the highest elevation of Alanine Aminotransferase (ALT)?

Active cirrhosis

What is the primary reason for the increase in ALP activity in liver disease?

Increased synthesis by liver cells

Which condition could result in a serum ALP level 2 times the reference interval?

Cholestasis

Where is ALP primarily produced in pregnant women?

Placenta

What is one of the consequences of increased ALP activity in growing bones?

Rapid growth of bone

In which condition might ALP levels from the intestine be increased?

Inflammatory bowel disease

Which enzyme is used by the body to synthesize glutathione tripeptide?

Gamma Glutamyl Transferase (GGT)

Which enzymes are typically within the normal range in Fatty Liver?

AST and ALT

What is considered the best marker for intrahepatic and extrahepatic cholestasis?

ALP

In which condition are liver enzyme concentrations notably increased, with AST and ALT being prominent?

Alcoholic Liver Disease

Which condition typically results in the largest elevations of ALP, due to gallstones or malignancy?

Cholestasis

What is a common effect of chronic liver failure on prothrombin and factors VII, IX, and X?

Decreased levels

Which statement is true regarding the effect of ethanol intake on cirrhosis?

Can be effectively reversed by immediate abstinence

Test your knowledge on conditions with increased ALT levels including hepatocellular disease, active cirrhosis, metastatic liver tumor, obstructive jaundice, and viral hepatitis. Suitable for students in the Clinical Biochemistry department of Pathological Analysis.

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