14 Questions
Which of the following is the primary function of the glucose-alanine cycle?
To allow non-hepatic tissues to deliver the amino portion of catabolized amino acids to the liver for excretion as urea.
Which molecule is transaminated to alanine in the glucose-alanine cycle?
Pyruvate
What is the donor of the amino group in the transamination reaction in the glucose-alanine cycle?
An α-amino acid
What is the indirect mechanism for muscle to eliminate nitrogen in the glucose-alanine cycle?
Transamination of pyruvate to alanine which is returned to the liver for gluconeogenesis.
What is the fate of the amino nitrogen in the glucose-alanine cycle?
It is converted to urea in the urea cycle.
What is the α-keto acid generated in the transamination reaction in the glucose-alanine cycle?
Depends on the α-amino acid used as the donor of the amino group.
What is the significance of the glucose-alanine cycle in energy metabolism?
It replenishes the energy supply of muscle and other peripheral tissues.
Which amino acid is used as a donor of the amino group in the transamination reaction that generates alanine?
Glutamine
What is the major function of the glucose-alanine cycle?
To deliver the amino portion of catabolized amino acids to the liver
What is the name of the cycle that describes the conversion of pyruvate to alanine and back to pyruvate in the liver?
Glucose-alanine cycle
What is the fate of the amino nitrogen in the urea cycle?
It is excreted as urea
What is the role of the transamination reaction in the glucose-alanine cycle?
To allow muscle cells to eliminate nitrogen while replenishing their energy supply
Which tissues are involved in the glucose-alanine cycle?
Both hepatic and non-hepatic tissues
What is the end product of the glucose-alanine cycle?
Glucose
Study Notes
Glucose-Alanine Cycle
- The primary function of the glucose-alanine cycle is to eliminate excess nitrogen in the form of alanine from muscles and convert it back to pyruvate in the liver.
- In the glucose-alanine cycle, pyruvate is transaminated to alanine.
- The donor of the amino group in the transamination reaction is glutamate.
- The indirect mechanism for muscle to eliminate nitrogen in the glucose-alanine cycle is by releasing alanine into the bloodstream, which is then transported to the liver.
- The fate of the amino nitrogen in the glucose-alanine cycle is that it is converted back to pyruvate in the liver and eventually used for gluconeogenesis.
- The α-keto acid generated in the transamination reaction is pyruvate.
- The significance of the glucose-alanine cycle in energy metabolism is that it allows muscles to conserve energy by eliminating excess nitrogen and converting it back to a usable energy source.
- Glutamate is the amino acid used as a donor of the amino group in the transamination reaction that generates alanine.
- The major function of the glucose-alanine cycle is to eliminate excess nitrogen from muscles and convert it back to a usable energy source in the liver.
- The process that describes the conversion of pyruvate to alanine and back to pyruvate in the liver is also known as the glucose-alanine cycle.
- The fate of the amino nitrogen in the urea cycle is that it is excreted in the form of urea.
- The role of the transamination reaction in the glucose-alanine cycle is to convert pyruvate to alanine and back to pyruvate.
- The tissues involved in the glucose-alanine cycle are muscles and liver.
- The end product of the glucose-alanine cycle is pyruvate, which can be used for gluconeogenesis.
Test your knowledge on the glucose-alanine cycle with this quiz! Learn about the process of transaminating pyruvate to alanine in muscles and its role in gluconeogenesis. Dive into the details of the α-amino acid donor and α-keto acid generation. Challenge yourself with questions that cover the indirect mechanism for muscle to eliminate excess nitrogen and maintain glucose levels.
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