Adrenocorticotropic Hormone (ACTH) and Cortisol Regulation
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Questions and Answers

What is the primary purpose of ACTH?

  • Stimulating the production of insulin
  • Maintaining blood pressure
  • Suppressing the immune system's response
  • Regulating glucose, protein, and lipid metabolism (correct)

Which gland produces ACTH?

  • Pituitary gland (correct)
  • Hypothalamus
  • Adrenal glands
  • Thyroid gland

What hormone stimulates the production of ACTH by the pituitary gland?

  • Thyroxine
  • Corticotropin-releasing hormone (CRH) (correct)
  • Insulin
  • Cortisol

When do ACTH levels increase?

<p>When cortisol is low (C)</p> Signup and view all the answers

What is the purpose of an ACTH test, usually in conjunction with cortisol tests?

<p>To help detect conditions associated with excessive or deficient cortisol in the body (D)</p> Signup and view all the answers

What can too much cortisol cause?

<p>Obesity and increased body hair (B)</p> Signup and view all the answers

How do patients with insufficient cortisol production typically present?

<p>Muscle weakness and fatigue (A)</p> Signup and view all the answers

When are ACTH and cortisol levels typically at their highest and lowest, respectively?

<p>Both at their highest in the morning (A)</p> Signup and view all the answers

What is the primary purpose of suppression or stimulation testing for ACTH and cortisol?

<p>To evaluate hormone production and function (C)</p> Signup and view all the answers

What are the primary symptoms of hypopituitarism?

<p>Decreased hormone production by the pituitary (B)</p> Signup and view all the answers

What does a decreased level of ACTH indicate in the context of testing for adrenal gland problems?

<p>Hypopituitarism (B)</p> Signup and view all the answers

What is the most common sample used for testing ACTH and cortisol levels?

<p>Fasting blood serum (early morning) (D)</p> Signup and view all the answers

Which hormone stimulates the production of cortisol by the adrenal glands?

<p>Corticotropin-releasing hormone (CRH) (C)</p> Signup and view all the answers

What are the primary functions of cortisol in the body?

<p>Regulating glucose, protein, and lipid metabolism (B)</p> Signup and view all the answers

What conditions can be diagnosed using ACTH blood tests in conjunction with cortisol tests?

<p>Cushing syndrome (B)</p> Signup and view all the answers

What symptoms can be associated with excessive cortisol production?

<p>Obesity and high potassium levels (A)</p> Signup and view all the answers

In which condition is both ACTH and cortisol increased?

<p>Cushing disease (pituitary tumor producing ACTH) (B)</p> Signup and view all the answers

What is the purpose of suppression or stimulation testing for ACTH and cortisol?

<p>To determine the cause of abnormal initial findings (A)</p> Signup and view all the answers

When are ACTH and cortisol levels typically at their highest?

<p>In the morning (C)</p> Signup and view all the answers

What are cardiac biomarkers?

<p>Chemical substances released into the blood when the heart is damaged or stressed</p> Signup and view all the answers

What is the most sensitive biomarker test for detecting heart damage?

<p>Troponin</p> Signup and view all the answers

What is the clinical utility of Aspartate aminotransferase (AST)?

<p>Hepatocellular and skeletal disorders</p> Signup and view all the answers

What is the primary role of myoglobin in the body?

<p>Oxygen binding protein of cardiac and skeletal muscle</p> Signup and view all the answers

Which enzyme accounts for only 3-20% of total CK activity in the heart?

<p>CK-MB (CK-2)</p> Signup and view all the answers

Where is lactate dehydrogenase (LDH) found?

<p>Skeletal muscle, liver, heart, kidney, and red blood cells</p> Signup and view all the answers

What is the composition of cardiac troponins?

<p>Complex of 3 protein subunits</p> Signup and view all the answers

Which enzyme is widely distributed in different tissues and has the highest concentrations in cardiac tissue, liver, and skeletal muscle?

<p>Aspartate aminotransferase (AST)</p> Signup and view all the answers

What is the clinical significance of myoglobin levels in the context of muscle trauma and AMI?

<p>Increased in cardiac muscle trauma, skeletal muscle trauma, and AMI</p> Signup and view all the answers

What is the total sensitivity and specificity of Creatine Kinase (CK or CPK)?

<p>%40 sensitive and %80 specific</p> Signup and view all the answers

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