Podcast
Questions and Answers
Which of the following is the main action of alpha adrenergic blockers?
Which of the following is the main action of alpha adrenergic blockers?
What is the main effect of phenoxybenzamine?
What is the main effect of phenoxybenzamine?
What is the duration of action for phentolamine as an alpha-1 antagonist?
What is the duration of action for phentolamine as an alpha-1 antagonist?
In what condition is phenoxybenzamine used to control episodes of hypertension?
In what condition is phenoxybenzamine used to control episodes of hypertension?
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What is the off-label use of phentolamine?
What is the off-label use of phentolamine?
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How does phentolamine affect the diameter of the pupil?
How does phentolamine affect the diameter of the pupil?
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Which class of drugs is primarily used for benign prostatic hyperplasia (BPH) and hypertension (HTN)?
Which class of drugs is primarily used for benign prostatic hyperplasia (BPH) and hypertension (HTN)?
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Which drug is linked to intraoperative floppy iris syndrome (IFIS), a risk factor for complications during cataract surgery?
Which drug is linked to intraoperative floppy iris syndrome (IFIS), a risk factor for complications during cataract surgery?
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Which drug facilitates the passage of kidney stones (ureterolithiasis) but is used off-label for this purpose?
Which drug facilitates the passage of kidney stones (ureterolithiasis) but is used off-label for this purpose?
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Which drug causes depletion of norepinephrine from central and peripheral synapses, leading to its anti-hypertensive effect?
Which drug causes depletion of norepinephrine from central and peripheral synapses, leading to its anti-hypertensive effect?
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Which beta-adrenergic blocking agent is commonly used in the treatment of supraventricular tachycardias?
Which beta-adrenergic blocking agent is commonly used in the treatment of supraventricular tachycardias?
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Which beta-adrenergic blocking agent has a combined alpha-1, beta-1, and beta-2 blocking action and can be given intravenously for hypertensive emergencies?
Which beta-adrenergic blocking agent has a combined alpha-1, beta-1, and beta-2 blocking action and can be given intravenously for hypertensive emergencies?
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Which drug blocks the release of storage norepinephrine and depletes the nerve ending of norepinephrine in the peripheral nervous system?
Which drug blocks the release of storage norepinephrine and depletes the nerve ending of norepinephrine in the peripheral nervous system?
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Which class of drugs includes drugs with intrinsic sympathomimetic activity (ISA) and hybrid antihypertensive drugs?
Which class of drugs includes drugs with intrinsic sympathomimetic activity (ISA) and hybrid antihypertensive drugs?
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Which drug is known for reducing the secretion of aqueous humor and is commonly used in the treatment of glaucoma?
Which drug is known for reducing the secretion of aqueous humor and is commonly used in the treatment of glaucoma?
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Which drug is primarily used for arrhythmia prophylaxis after a myocardial infarction?
Which drug is primarily used for arrhythmia prophylaxis after a myocardial infarction?
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Which drug has a nonselective beta-blocking action and also blocks alpha-1 receptors?
Which drug has a nonselective beta-blocking action and also blocks alpha-1 receptors?
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Which drug is used to reduce the potential for arrhythmias in patients with thyrotoxicosis?
Which drug is used to reduce the potential for arrhythmias in patients with thyrotoxicosis?
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Study Notes
Alpha Adrenergic Blockers
- Alpha adrenergic blockers main action is to block the vasoconstrictor effect of catecholamines
Phenoxybenzamine
- Phenoxybenzamine's main effect is to produce long-lasting blockade of alpha receptors
- Duration of action: long-acting alpha-1 antagonist
- Used to control episodes of hypertension in pheochromocytoma patients
Phentolamine
- Duration of action: short-acting alpha-1 antagonist
- Off-label use: diagnosis of pheochromocytoma
- Affects pupil diameter: causes mydriasis (dilation)
Benign Prostatic Hyperplasia (BPH) and Hypertension (HTN)
- Alpha-1 blockers are primarily used to treat BPH and HTN
Intraoperative Floppy Iris Syndrome (IFIS)
- Phenoxybenzamine is linked to IFIS, a risk factor for complications during cataract surgery
Kidney Stones (Ureterolithiasis)
- Phentolamine facilitates the passage of kidney stones (off-label use)
Anti-Hypertensive Effects
- Reserpine causes depletion of norepinephrine from central and peripheral synapses, leading to its anti-hypertensive effect
Beta-Adrenergic Blockers
- Esmolol is commonly used to treat supraventricular tachycardias
- Labetalol has a combined alpha-1, beta-1, and beta-2 blocking action and can be given intravenously for hypertensive emergencies
Norepinephrine Release
- Reserpine blocks the release of storage norepinephrine and depletes the nerve ending of norepinephrine in the peripheral nervous system
Beta-Adrenergic Blocking Agents
- Class includes drugs with intrinsic sympathomimetic activity (ISA) and hybrid antihypertensive drugs
Glaucoma Treatment
- Timolol reduces the secretion of aqueous humor and is commonly used in the treatment of glaucoma
Arrhythmia Prophylaxis
- Propranolol is primarily used for arrhythmia prophylaxis after a myocardial infarction
- Propranolol has a nonselective beta-blocking action and also blocks alpha-1 receptors
- Propranolol is used to reduce the potential for arrhythmias in patients with thyrotoxicosis
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Description
Test your knowledge about the actions and effects of adrenergic antagonists, specifically alpha adrenergic blockers, on the sympathetic tone of blood vessels and the cardiovascular system.
