18 Questions
Why is the warning not to use Acyclovir cream and ointment in the eye necessary?
Because the cream contains ingredients that are irritant to the eyes
What is the function of Poloxamer 407 in Zovirax Cream 5%?
Hydrophilic non-ionic surfactant
Why is Acyclovir 5% cream not recommended for use on the genitals?
Because it is not effective in treating genital herpes
What is the main advantage of using ointment bases like PEG?
They provide a hydrophobic barrier on the skin surface
What is the role of mineral oil in Zovirax Cream 5%?
Hydrocarbon (oleaginous part) and can also serve as a levigating agent
Why is the efficacy of Acyclovir 5% cream in treating genital herpes limited?
Because it only decreases the duration of itching compared to placebo
What is the primary concern regarding the storage of acyclovir ointment?
Chemical stability of acyclovir in the presence of water
What patient counseling point is necessary to reduce systemic absorption of acyclovir from topical products?
Avoiding unnecessary rubbing of the affected area
What is the primary reason why acyclovir is formulated in a PEG ointment base?
To enhance its water solubility
What is the primary advantage of using a cream formulation of acyclovir?
Improved physical stability of the emulsion
What would be the consequence of formulating acyclovir in a hydrocarbon base?
Delayed drug release due to lipophilicity
What is a contraindication for the use of topical acyclovir products?
Open wounds or broken skin
What is the maximum solubility of acyclovir in water at 37°C?
2.5 mg/mL
What is the primary advantage of PEG ointment bases in terms of texture properties?
Stiffness and Adhesiveness
What is a scenario that would increase the systemic absorption of acyclovir from topical products?
Shaving the affected area to enhance skin permeation
What is the effect of PEG 1500 on the ointment base?
Increases the hydrophilicity of the ointment base
What is the primary concern regarding the use of PEG ointment bases in acyclovir formulations?
Hygroscopicity of the ointment base
What is the range of solubility of acyclovir in water?
1.2-1.6 mg/mL
Learn about the necessary precautions and warnings when using acyclovir cream and ointment, including avoidance of certain areas of the body and potential irritation.
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