10 Questions
Which of the following is NOT a detrimental effect of sustained elevations or abnormally large increases in cytosolic free Ca2+?
Inhibition of membrane transporters
What is believed to induce cellular injury through the release of lysosomal enzymes and toxicants into the cytoplasm?
Rupture of lysosomes
Which of the following is NOT a key subcellular target of aminoglycosides, unleaded gasoline, and d-limonene?
Lysosomes
Which of the following enzyme families hydrolyzes phospholipids, potentially impairing membrane function?
Phospholipase A2 (PLA2)
What is the primary cause of the loss of ATP, which results in the inhibition of membrane transporters that maintain internal ion balance?
Inhibition of energy production
Which of the following enzymes is NOT mentioned in the passage as being activated by an increase in cytosolic free Ca2+?
Endonucleases
Which of the following statements about mitochondria is NOT true, according to the passage?
Mitochondria play a major role in normal cellular Ca2+ regulation.
What is the primary mechanism by which toxicants disrupt cell volume and ion homeostasis, according to the passage?
Both A and B
Which of the following statements about the distribution of Ca2+ in renal cells is true, according to the passage?
The distribution of Ca2+ in renal cells is complex.
Which of the following statements is NOT true, based on the information provided in the passage?
Proteinases and calpains are not Ca2+-dependent enzymes.
Explore the various causes and mechanisms of Acute Kidney Injury (AKI), including dehydration, infection, heart failure, medication toxicity, and nephrotoxicants. Learn about the reversible nature of AKI with proper treatment and the potential risks of permanent kidney damage or failure.
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