Questions and Answers
Which of the following are misc acid controlling drugs? (Select all that apply)
What is sucralfate (Carafate) indicated for?
Stress ulcers and peptic ulcer disease
What is the mechanism of action (MOA) for sucralfate (Carafate)?
Binds to ulcers and erosions, forming a protective barrier
What are the side effects of sucralfate (Carafate)? (Select all that apply)
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What should be considered when administering sucralfate (Carafate)?
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When teaching a patient about sucralfate (Carafate) therapy, which statement is correct?
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What are the H2 antagonists drugs?
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What is the mechanism of action (MOA) for H2 antagonists?
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What are the adverse effects of ranitidine (Zantac) in elderly patients?
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What is a drug interaction concern with H2 antagonists?
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Study Notes
Miscellaneous Acid Controlling Drugs
- Sucralfate (Carafate) and Misoprostol (Cytotec) are classified as acid-controlling medications.
Sucralfate (Carafate) Indications
- Indicated for stress ulcers and peptic ulcer disease.
- Binds with phosphate; beneficial in chronic renal failure to lower phosphate levels.
Mechanism of Action (MOA) of Sucralfate
- Binds to the base of ulcers and erosions, creating a protective barrier.
- Protects ulcerated areas from pepsin, an enzyme that can worsen ulcers.
Side Effects of Sucralfate
- Common side effects include constipation, nausea, and dry mouth.
Special Administration Guidelines for Sucralfate
- Can impair the absorption of other medications; other drugs should be taken at least 2 hours before sucralfate.
- Administer alone; avoid giving with other medications.
Patient Education on Sucralfate Therapy
- Correct teaching includes that sucralfate binds to exposed proteins and concentrates epidermal growth factor to aid in ulcer healing.
- Sucralfate acts locally at the ulcer site rather than systemically.
- Its effects are transient, requiring multiple doses throughout the day.
Histamine H2 Antagonists
- Known as "tidines", include Nizatidine (Axid), Famotidine (Pepcid), Cimetidine (Tagamet), and Ranitidine (Zantac).
- Available over-the-counter (OTC) in lower doses and reduce acid secretion.
H2 Antagonist Mechanism of Action
- Completely block H2 receptors on acid-producing parietal cells.
- Decrease hydrogen ion secretion, raising stomach pH.
- Provide relief from symptoms linked to hyperacidity.
Ranitidine (Zantac) Adverse Effects
- In elderly patients, can cause confusion and disorientation.
- Risk of thrombocytopenia (low platelet count).
H2 Antagonist Drug Interactions
- Smoking significantly reduces the effectiveness of H2 blockers.
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Description
This quiz explores the indications, mechanisms, and side effects of Sucralfate (Carafate) as an acid-controlling medication. Understand its role in treating stress ulcers and its effects on other drugs. Learn the special administration guidelines and patient education essentials for effective therapy.
