Acid-Base Balance Quiz

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Questions and Answers

What is the normal pH range for arterial blood?

  • 7.35 - 7.45 (correct)
  • 7.0 - 7.35
  • 7.4 - 7.5
  • 7.45 - 8.0

How does hypo-ventilation affect blood pH?

  • Increases blood pH due to more carbon dioxide
  • Has no effect on blood pH
  • Decreases blood pH due to more oxygen
  • Decreases blood pH due to increased carbon dioxide (correct)

What condition is indicated when arterial blood pH is less than 7.35?

  • Hyperventilation
  • Respiratory alkalosis
  • Alkalosis
  • Acidemia (correct)

Which buffer system primarily responds to changes in intracellular fluid (ICF) pH?

<p>Phosphate buffer system (B)</p> Signup and view all the answers

What is the role of bicarbonate ions in the regulation of blood pH?

<p>Neutralize excess hydrogen ions (B)</p> Signup and view all the answers

During which condition would the respiratory system attempt to compensate for metabolic acidosis?

<p>Hyperventilation (D)</p> Signup and view all the answers

What is a primary consequence of renal retention of bicarbonate ions?

<p>Increased blood pH (D)</p> Signup and view all the answers

High levels of PCO2 in arterial blood are indicative of which condition?

<p>Respiratory acidosis (C)</p> Signup and view all the answers

Which factor contributes to respiratory alkalosis?

<p>Hyperventilation (C)</p> Signup and view all the answers

Which process is primarily responsible for the secretion of hydrogen ions by the kidneys?

<p>Tubular secretion (A)</p> Signup and view all the answers

The normal pH of arterial blood is 7.4.

<p>True (A)</p> Signup and view all the answers

Alkalosis is defined as arterial pH greater than 7.45.

<p>True (A)</p> Signup and view all the answers

Venous blood has a higher pH than interstitial fluid (IF) fluid.

<p>False (B)</p> Signup and view all the answers

A patient with a blood pH of 7.0 is in a state of acidosis.

<p>True (A)</p> Signup and view all the answers

Hyperventilation causes an increase in blood pH.

<p>True (A)</p> Signup and view all the answers

The phosphate buffer system has the least significant role in blood pH regulation compared to bicarbonate and protein buffers.

<p>True (A)</p> Signup and view all the answers

The kidneys retain hydrogen ions to increase blood pH.

<p>False (B)</p> Signup and view all the answers

Metabolic alkalosis can occur due to excessive bicarbonate retention by the kidneys.

<p>True (A)</p> Signup and view all the answers

Hypoventilation generally leads to decreased levels of PCO2 in arterial blood.

<p>False (B)</p> Signup and view all the answers

The bicarbonate buffer system is primarily effective in the intracellular fluid (ICF).

<p>False (B)</p> Signup and view all the answers

What is the normal pH of venous blood?

<p>7.35 (A)</p> Signup and view all the answers

Acidosis is defined as arterial pH less than 7.35.

<p>True (A)</p> Signup and view all the answers

What role do the kidneys play in regulating blood pH?

<p>The kidneys secrete hydrogen ions and retain bicarbonate ions to help regulate blood pH.</p> Signup and view all the answers

The normal range for PCO2 in arterial blood is between _____ mmHg.

<p>35-45</p> Signup and view all the answers

Match the following buffer systems with their primary function:

<p>Bicarbonate buffer system = Regulates blood pH Phosphate buffer system = Affects intracellular pH Protein buffer system = Maintains pH in blood and interstitial fluid Respiratory system = Regulates gas exchange and blood pH</p> Signup and view all the answers

Which condition is characterized by arterial pH greater than 7.45?

<p>Alkalosis (C)</p> Signup and view all the answers

Hyperventilation results in decreased blood pH.

<p>False (B)</p> Signup and view all the answers

What happens to blood pH during hypoventilation?

<p>Blood pH decreases (becomes more acidic) due to increased levels of carbon dioxide.</p> Signup and view all the answers

The bicarbonate buffer system is primarily effective in the _____ fluid.

<p>extracellular</p> Signup and view all the answers

Which of the following conditions can lead to metabolic alkalosis?

<p>Excessive bicarbonate retention (D)</p> Signup and view all the answers

What is the primary role of the bicarbonate buffer system?

<p>To regulate blood pH by maintaining bicarbonate ions (D)</p> Signup and view all the answers

Acidosis is the condition where arterial blood pH is less than 7.35.

<p>True (A)</p> Signup and view all the answers

What pH is considered normal for arterial blood?

<p>7.4</p> Signup and view all the answers

Match the buffer systems to their primary functionality:

<p>Bicarbonate buffer system = Regulates blood pH Phosphate buffer system = Functions in the kidneys and ICF Protein buffer system = Buffers pH in blood and ICF</p> Signup and view all the answers

What effect does hyperventilation usually have on blood pH?

<p>It increases blood pH (C)</p> Signup and view all the answers

The protein buffer system plays a minor role in maintaining blood pH compared to bicarbonate and phosphate systems.

<p>False (B)</p> Signup and view all the answers

What condition occurs when arterial pH exceeds 7.45?

<p>Alkalosis</p> Signup and view all the answers

During hypoventilation, the levels of _____ typically increase in the blood.

<p>PCO2</p> Signup and view all the answers

Which buffer system is primarily effective in regulating pH in the extracellular fluid?

<p>Bicarbonate buffer system (D)</p> Signup and view all the answers

Which statement correctly describes the role of buffers in maintaining blood pH?

<p>Buffers can donate or accept hydrogen ions to stabilize pH levels. (C)</p> Signup and view all the answers

What is the relationship between PCO2 and blood pH?

<p>Increasing PCO2 levels generally decrease blood pH. (C)</p> Signup and view all the answers

How do the kidneys affect blood pH in response to acidosis?

<p>They excrete hydrogen ions and retain bicarbonate. (A)</p> Signup and view all the answers

What is a physiological consequence of hyperventilation?

<p>It elevates blood pH, leading to respiratory alkalosis. (B)</p> Signup and view all the answers

Which buffer system is most effective in the regulation of blood pH?

<p>Bicarbonate buffer system. (C)</p> Signup and view all the answers

Which condition is associated with a decrease in blood pH?

<p>Respiratory acidosis. (B)</p> Signup and view all the answers

In which scenario would the bicarbonate system be utilized for compensation?

<p>To neutralize excess hydrogen ions in metabolic acidosis. (B)</p> Signup and view all the answers

What factor is likely to disrupt homeostasis and induce respiratory acidosis?

<p>Chronic lung disease leading to CO2 retention. (B)</p> Signup and view all the answers

How does the phosphate buffer system primarily function in the body?

<p>By donating protons in the intracellular fluid. (D)</p> Signup and view all the answers

What defines the concept of compensation in acid-base balance?

<p>One system (respiratory or renal) adjusts to counteract changes from the other. (C)</p> Signup and view all the answers

The normal pH range for arterial blood is _____ to 7.45.

<p>7.35</p> Signup and view all the answers

Acidosis or acidemia is defined as arterial pH _____ 7.35.

<p>less than</p> Signup and view all the answers

Hyperventilation typically results in an increase in blood _____.

<p>pH</p> Signup and view all the answers

The _____ buffer system is primarily effective in the extracellular fluid.

<p>bicarbonate</p> Signup and view all the answers

A blood pH of 7.0 indicates a state of _____.

<p>acidosis</p> Signup and view all the answers

The normal range for _____ in arterial blood is between 35 to 45 mmHg.

<p>PCO2</p> Signup and view all the answers

The phosphate buffer system has a significant role in regulating pH in _____ fluid.

<p>intracellular</p> Signup and view all the answers

Alkalosis or alkalemia is characterized by arterial pH _____ 7.45.

<p>greater than</p> Signup and view all the answers

The kidneys help to regulate blood pH by secreting _____ ions.

<p>hydrogen</p> Signup and view all the answers

Metabolic alkalosis can occur due to excessive retention of _____ by the kidneys.

<p>bicarbonate</p> Signup and view all the answers

Flashcards

Acid

A substance that releases hydrogen ions (H+) in a solution.

Base

A substance that accepts hydrogen ions (H+) in a solution.

pH

A measure of the concentration of hydrogen ions (H+) in a solution, on a scale of 0 to 14.

Buffer

A substance that resists changes in pH by absorbing or releasing H+ ions.

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Normal arterial blood pH

7.4

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Alkalosis

Arterial blood pH above 7.45.

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Acidosis

Arterial blood pH below 7.35.

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Bicarbonate buffer system

A buffer system in blood that helps maintain pH by taking up excess hydrogen ions.

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Respiratory system role in pH

The respiratory system regulates blood pH by controlling the amount of carbon dioxide (CO2) in the blood.

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Kidneys role in pH

The kidneys regulate blood pH by excreting hydrogen ions (H+) and reabsorbing bicarbonate (HCO3-).

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What is the normal pH range for arterial blood?

The normal pH range for arterial blood is 7.35 to 7.45. Maintaining this narrow range is crucial for proper body function.

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What happens when arterial blood pH is above 7.45?

Arterial blood pH above 7.45 is called alkalosis or alkalemia. It's a state of too much alkalinity in the blood.

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What happens when arterial blood pH is below 7.35?

Arterial blood pH below 7.35 is called acidosis or acidemia. It's a state of too much acidity in the blood.

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Explain how the bicarbonate buffer system works.

The bicarbonate buffer system uses carbonic acid (H2CO3) and bicarbonate ions (HCO3-) to neutralize excess acid or base. It's the primary buffer system in blood.

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Explain the role of the respiratory system in pH regulation.

The respiratory system regulates blood pH by controlling the amount of CO2 in the blood. Higher CO2 levels lead to more acid, while lower CO2 levels lead to more alkalinity.

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Explain how the kidneys regulate blood pH.

The kidneys regulate blood pH by excreting H+ ions and reabsorbing HCO3- ions. They help remove excess acid and conserve bicarbonate, keeping the blood at a stable pH.

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What is the relationship between PCO2 and HCO3-?

PCO2 (partial pressure of carbon dioxide) and HCO3- (bicarbonate) are inversely related. When PCO2 is high, HCO3- is low, and vice versa.

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Describe the concept of compensation in acid-base imbalances.

Compensation is the body's attempt to return blood pH to normal by adjusting either respiratory or metabolic mechanisms when one system is out of balance.

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How do hypoventilation and hyperventilation affect blood pH?

Hypoventilation (slow, shallow breathing) increases CO2 in the blood, leading to respiratory acidosis. Hyperventilation (rapid, deep breathing) decreases CO2, leading to respiratory alkalosis.

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What are the mechanisms by which the kidneys secrete hydrogen ions?

The kidneys secrete H+ ions through active transport mechanisms. They use proton pumps to move H+ into the urine, effectively removing acid from the body.

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What is pH?

pH measures the acidity or alkalinity of a solution, using a scale from 0 to 14, with 7 being neutral. Lower pH means more acidic, while higher pH means more alkaline.

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Normal pH range of arterial blood

Arterial blood normally has a pH between 7.35 and 7.45. This narrow range is crucial for proper body function.

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What is acidosis?

Acidosis is a condition where blood pH falls below 7.35. It means the blood is too acidic.

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What is alkalosis?

Alkalosis is a condition where blood pH rises above 7.45. It means the blood is too alkaline.

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What is a buffer?

A buffer is a substance that resists changes in pH by absorbing or releasing hydrogen ions (H+).

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Role of respiratory system in pH

The respiratory system controls your breathing rate and depth, which impacts the amount of carbon dioxide (CO2) in your blood. CO2 contributes to acidity, so your lungs help maintain pH.

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Role of kidneys in pH

The kidneys regulate pH by removing excess acid (H+) from the blood and conserving bicarbonate (HCO3-).

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What is compensation in acid-base balance?

Compensation is your body's way of trying to bring your blood pH back to normal. It involves adjusting either respiratory mechanisms (breathing) or metabolic mechanisms (chemical reactions) when one system is out of balance.

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Compensation (in acid-base balance)

The body's attempt to return blood pH to normal by adjusting either respiratory or metabolic mechanisms when one system is out of balance.

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Role of the Respiratory System in pH

The respiratory system controls your breathing rate and depth, which impacts the amount of carbon dioxide (CO2) in your blood. CO2 contributes to acidity, so your lungs help maintain pH.

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Role of the Kidneys in pH

The kidneys regulate pH by removing excess acid (H+) from the blood and conserving bicarbonate (HCO3-).

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Compensation in acid-base imbalance

Compensation is the body's attempt to return blood pH to normal by adjusting either respiratory or metabolic mechanisms when one system is out of balance.

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Hypoventilation/Hyperventilation and Blood pH

Hypoventilation (slow, shallow breathing) increases CO2 in the blood, leading to respiratory acidosis. Hyperventilation (rapid, deep breathing) decreases CO2, leading to respiratory alkalosis.

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How do the kidneys secrete hydrogen ions?

The kidneys secrete H+ ions through active transport mechanisms. They use proton pumps to move H+ into the urine, effectively removing acid from the body.

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Study Notes

Acid-Base Balance

  • pH affects all functional proteins and biochemical reactions, tightly regulated in the body.
  • Normal pH range for arterial blood is 7.4.
  • Venous blood and interstitial fluid (IF) pH is 7.35.
  • Intracellular fluid (ICF) pH is 7.0.
  • Alkalosis, or alkalemia, is an arterial pH greater than 7.45.
  • Acidosis, or acidemia, is an arterial pH less than 7.35.
  • Blood pH below 6.8 leads to CNS depression, coma, and death as ultimate outcomes.
  • Blood pH above 7.8 leads to nervous system excitation, muscle tetany, extreme nervousness, convulsions, and death from respiratory arrest.

Learning Objectives

  • Define acid, base, pH, and buffer.
  • State the normal pH range for arterial blood.
  • State the chemical equation of the bicarbonate, phosphate, and protein buffer systems.
  • Explain the roles of these buffer systems in regulating blood, interstitial fluid, and intracellular pH, including how they respond to pH changes.
  • State the normal ranges for PCO2 and HCO3- in arterial blood, and summarize their relationship to blood pH.
  • Describe the role of the respiratory system in regulating blood pH and predict how hypo- and hyperventilation affect blood pH.
  • Explain the mechanisms by which kidneys secrete hydrogen ions, and how this affects blood pH.
  • Explain the mechanisms by which kidneys retain bicarbonate ions, and how this affects blood pH.
  • Discuss compensation for respiratory and metabolic acidosis and alkalosis.
  • Determine whether a patient is in normal pH, respiratory acidosis/alkalosis, or metabolic acidosis/alkalosis based on blood gas values and whether the acidosis or alkalosis is compensated.
  • Describe how the cardiovascular, endocrine, respiratory, and urinary systems maintain homeostasis.
  • Predict factors or situations that lead to respiratory or metabolic acidosis or alkalosis.

Sources of Acid Production

  • Small amounts of acidic substances in food; mostly H+ is a byproduct of metabolism.
  • Breakdown of phosphorus-containing proteins releases phosphoric acid into extracellular fluid (ECF).
  • Lactic acid from anaerobic glucose respiration.
  • Fatty acids and ketone bodies from fat metabolism.
  • H+ is liberated when CO2 is converted to HCO3- in blood.

Acid-Base Regulation Mechanisms

  • Chemical buffer systems (first line of defense, rapid, acts within 1-3 minutes).
  • Brain stem respiratory centers (rapid, first line of defense, acts within 1-3 minutes).
  • Renal mechanisms (most potent, require hours to days to effect pH changes).

Chemical Buffer Systems

  • Chemical buffers: One or more compounds resisting pH changes when a strong acid or base is added.

    • Bind H+ if pH drops; release H+ if pH increases.
  • Bicarbonate buffer system: Mixture of H2CO3 (weak acid) and salts of HCO3- (weak base), major ECF buffer.

  • Phosphate buffer system: Dihydrogen phosphate (H2PO4-), a weak acid, and monohydrogen phosphate (HPO42-), a weak base.

  • Protein buffer system: Intracellular proteins, most powerful buffers, plasma proteins, act as both weak acid and weak base, influenced by changes in pH.

Physiological Buffering Systems

  • Respiratory and renal systems regulate the amount of acid or base in the body, operate more slowly than chemical buffer systems, and have more capacity than chemical buffers.

Acid-Base Imbalances

  • Chemical buffers cannot eliminate excess acids or bases from the body; however, physiological (respiratory and renal) buffers can.
  • Lungs eliminate volatile carbonic acid by eliminating CO2.
  • Kidneys eliminate nonvolatile acids (phosphoric, uric, lactic, and ketones) and regulate alkaline substances.
  • Respiratory and renal systems compensate for imbalances by other respective organs.

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