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Questions and Answers
What is the normal pH range for arterial blood?
What is the normal pH range for arterial blood?
- 7.35 - 7.45 (correct)
- 7.0 - 7.35
- 7.4 - 7.5
- 7.45 - 8.0
How does hypo-ventilation affect blood pH?
How does hypo-ventilation affect blood pH?
- Increases blood pH due to more carbon dioxide
- Has no effect on blood pH
- Decreases blood pH due to more oxygen
- Decreases blood pH due to increased carbon dioxide (correct)
What condition is indicated when arterial blood pH is less than 7.35?
What condition is indicated when arterial blood pH is less than 7.35?
- Hyperventilation
- Respiratory alkalosis
- Alkalosis
- Acidemia (correct)
Which buffer system primarily responds to changes in intracellular fluid (ICF) pH?
Which buffer system primarily responds to changes in intracellular fluid (ICF) pH?
What is the role of bicarbonate ions in the regulation of blood pH?
What is the role of bicarbonate ions in the regulation of blood pH?
During which condition would the respiratory system attempt to compensate for metabolic acidosis?
During which condition would the respiratory system attempt to compensate for metabolic acidosis?
What is a primary consequence of renal retention of bicarbonate ions?
What is a primary consequence of renal retention of bicarbonate ions?
High levels of PCO2 in arterial blood are indicative of which condition?
High levels of PCO2 in arterial blood are indicative of which condition?
Which factor contributes to respiratory alkalosis?
Which factor contributes to respiratory alkalosis?
Which process is primarily responsible for the secretion of hydrogen ions by the kidneys?
Which process is primarily responsible for the secretion of hydrogen ions by the kidneys?
The normal pH of arterial blood is 7.4.
The normal pH of arterial blood is 7.4.
Alkalosis is defined as arterial pH greater than 7.45.
Alkalosis is defined as arterial pH greater than 7.45.
Venous blood has a higher pH than interstitial fluid (IF) fluid.
Venous blood has a higher pH than interstitial fluid (IF) fluid.
A patient with a blood pH of 7.0 is in a state of acidosis.
A patient with a blood pH of 7.0 is in a state of acidosis.
Hyperventilation causes an increase in blood pH.
Hyperventilation causes an increase in blood pH.
The phosphate buffer system has the least significant role in blood pH regulation compared to bicarbonate and protein buffers.
The phosphate buffer system has the least significant role in blood pH regulation compared to bicarbonate and protein buffers.
The kidneys retain hydrogen ions to increase blood pH.
The kidneys retain hydrogen ions to increase blood pH.
Metabolic alkalosis can occur due to excessive bicarbonate retention by the kidneys.
Metabolic alkalosis can occur due to excessive bicarbonate retention by the kidneys.
Hypoventilation generally leads to decreased levels of PCO2 in arterial blood.
Hypoventilation generally leads to decreased levels of PCO2 in arterial blood.
The bicarbonate buffer system is primarily effective in the intracellular fluid (ICF).
The bicarbonate buffer system is primarily effective in the intracellular fluid (ICF).
What is the normal pH of venous blood?
What is the normal pH of venous blood?
Acidosis is defined as arterial pH less than 7.35.
Acidosis is defined as arterial pH less than 7.35.
What role do the kidneys play in regulating blood pH?
What role do the kidneys play in regulating blood pH?
The normal range for PCO2 in arterial blood is between _____ mmHg.
The normal range for PCO2 in arterial blood is between _____ mmHg.
Match the following buffer systems with their primary function:
Match the following buffer systems with their primary function:
Which condition is characterized by arterial pH greater than 7.45?
Which condition is characterized by arterial pH greater than 7.45?
Hyperventilation results in decreased blood pH.
Hyperventilation results in decreased blood pH.
What happens to blood pH during hypoventilation?
What happens to blood pH during hypoventilation?
The bicarbonate buffer system is primarily effective in the _____ fluid.
The bicarbonate buffer system is primarily effective in the _____ fluid.
Which of the following conditions can lead to metabolic alkalosis?
Which of the following conditions can lead to metabolic alkalosis?
What is the primary role of the bicarbonate buffer system?
What is the primary role of the bicarbonate buffer system?
Acidosis is the condition where arterial blood pH is less than 7.35.
Acidosis is the condition where arterial blood pH is less than 7.35.
What pH is considered normal for arterial blood?
What pH is considered normal for arterial blood?
Match the buffer systems to their primary functionality:
Match the buffer systems to their primary functionality:
What effect does hyperventilation usually have on blood pH?
What effect does hyperventilation usually have on blood pH?
The protein buffer system plays a minor role in maintaining blood pH compared to bicarbonate and phosphate systems.
The protein buffer system plays a minor role in maintaining blood pH compared to bicarbonate and phosphate systems.
What condition occurs when arterial pH exceeds 7.45?
What condition occurs when arterial pH exceeds 7.45?
During hypoventilation, the levels of _____ typically increase in the blood.
During hypoventilation, the levels of _____ typically increase in the blood.
Which buffer system is primarily effective in regulating pH in the extracellular fluid?
Which buffer system is primarily effective in regulating pH in the extracellular fluid?
Which statement correctly describes the role of buffers in maintaining blood pH?
Which statement correctly describes the role of buffers in maintaining blood pH?
What is the relationship between PCO2 and blood pH?
What is the relationship between PCO2 and blood pH?
How do the kidneys affect blood pH in response to acidosis?
How do the kidneys affect blood pH in response to acidosis?
What is a physiological consequence of hyperventilation?
What is a physiological consequence of hyperventilation?
Which buffer system is most effective in the regulation of blood pH?
Which buffer system is most effective in the regulation of blood pH?
Which condition is associated with a decrease in blood pH?
Which condition is associated with a decrease in blood pH?
In which scenario would the bicarbonate system be utilized for compensation?
In which scenario would the bicarbonate system be utilized for compensation?
What factor is likely to disrupt homeostasis and induce respiratory acidosis?
What factor is likely to disrupt homeostasis and induce respiratory acidosis?
How does the phosphate buffer system primarily function in the body?
How does the phosphate buffer system primarily function in the body?
What defines the concept of compensation in acid-base balance?
What defines the concept of compensation in acid-base balance?
The normal pH range for arterial blood is _____ to 7.45.
The normal pH range for arterial blood is _____ to 7.45.
Acidosis or acidemia is defined as arterial pH _____ 7.35.
Acidosis or acidemia is defined as arterial pH _____ 7.35.
Hyperventilation typically results in an increase in blood _____.
Hyperventilation typically results in an increase in blood _____.
The _____ buffer system is primarily effective in the extracellular fluid.
The _____ buffer system is primarily effective in the extracellular fluid.
A blood pH of 7.0 indicates a state of _____.
A blood pH of 7.0 indicates a state of _____.
The normal range for _____ in arterial blood is between 35 to 45 mmHg.
The normal range for _____ in arterial blood is between 35 to 45 mmHg.
The phosphate buffer system has a significant role in regulating pH in _____ fluid.
The phosphate buffer system has a significant role in regulating pH in _____ fluid.
Alkalosis or alkalemia is characterized by arterial pH _____ 7.45.
Alkalosis or alkalemia is characterized by arterial pH _____ 7.45.
The kidneys help to regulate blood pH by secreting _____ ions.
The kidneys help to regulate blood pH by secreting _____ ions.
Metabolic alkalosis can occur due to excessive retention of _____ by the kidneys.
Metabolic alkalosis can occur due to excessive retention of _____ by the kidneys.
Flashcards
Acid
Acid
A substance that releases hydrogen ions (H+) in a solution.
Base
Base
A substance that accepts hydrogen ions (H+) in a solution.
pH
pH
A measure of the concentration of hydrogen ions (H+) in a solution, on a scale of 0 to 14.
Buffer
Buffer
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Normal arterial blood pH
Normal arterial blood pH
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Alkalosis
Alkalosis
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Acidosis
Acidosis
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Bicarbonate buffer system
Bicarbonate buffer system
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Respiratory system role in pH
Respiratory system role in pH
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Kidneys role in pH
Kidneys role in pH
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What is the normal pH range for arterial blood?
What is the normal pH range for arterial blood?
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What happens when arterial blood pH is above 7.45?
What happens when arterial blood pH is above 7.45?
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What happens when arterial blood pH is below 7.35?
What happens when arterial blood pH is below 7.35?
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Explain how the bicarbonate buffer system works.
Explain how the bicarbonate buffer system works.
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Explain the role of the respiratory system in pH regulation.
Explain the role of the respiratory system in pH regulation.
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Explain how the kidneys regulate blood pH.
Explain how the kidneys regulate blood pH.
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What is the relationship between PCO2 and HCO3-?
What is the relationship between PCO2 and HCO3-?
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Describe the concept of compensation in acid-base imbalances.
Describe the concept of compensation in acid-base imbalances.
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How do hypoventilation and hyperventilation affect blood pH?
How do hypoventilation and hyperventilation affect blood pH?
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What are the mechanisms by which the kidneys secrete hydrogen ions?
What are the mechanisms by which the kidneys secrete hydrogen ions?
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What is pH?
What is pH?
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Normal pH range of arterial blood
Normal pH range of arterial blood
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What is acidosis?
What is acidosis?
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What is alkalosis?
What is alkalosis?
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What is a buffer?
What is a buffer?
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Role of respiratory system in pH
Role of respiratory system in pH
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Role of kidneys in pH
Role of kidneys in pH
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What is compensation in acid-base balance?
What is compensation in acid-base balance?
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Compensation (in acid-base balance)
Compensation (in acid-base balance)
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Role of the Respiratory System in pH
Role of the Respiratory System in pH
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Role of the Kidneys in pH
Role of the Kidneys in pH
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Compensation in acid-base imbalance
Compensation in acid-base imbalance
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Hypoventilation/Hyperventilation and Blood pH
Hypoventilation/Hyperventilation and Blood pH
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How do the kidneys secrete hydrogen ions?
How do the kidneys secrete hydrogen ions?
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Study Notes
Acid-Base Balance
- pH affects all functional proteins and biochemical reactions, tightly regulated in the body.
- Normal pH range for arterial blood is 7.4.
- Venous blood and interstitial fluid (IF) pH is 7.35.
- Intracellular fluid (ICF) pH is 7.0.
- Alkalosis, or alkalemia, is an arterial pH greater than 7.45.
- Acidosis, or acidemia, is an arterial pH less than 7.35.
- Blood pH below 6.8 leads to CNS depression, coma, and death as ultimate outcomes.
- Blood pH above 7.8 leads to nervous system excitation, muscle tetany, extreme nervousness, convulsions, and death from respiratory arrest.
Learning Objectives
- Define acid, base, pH, and buffer.
- State the normal pH range for arterial blood.
- State the chemical equation of the bicarbonate, phosphate, and protein buffer systems.
- Explain the roles of these buffer systems in regulating blood, interstitial fluid, and intracellular pH, including how they respond to pH changes.
- State the normal ranges for PCO2 and HCO3- in arterial blood, and summarize their relationship to blood pH.
- Describe the role of the respiratory system in regulating blood pH and predict how hypo- and hyperventilation affect blood pH.
- Explain the mechanisms by which kidneys secrete hydrogen ions, and how this affects blood pH.
- Explain the mechanisms by which kidneys retain bicarbonate ions, and how this affects blood pH.
- Discuss compensation for respiratory and metabolic acidosis and alkalosis.
- Determine whether a patient is in normal pH, respiratory acidosis/alkalosis, or metabolic acidosis/alkalosis based on blood gas values and whether the acidosis or alkalosis is compensated.
- Describe how the cardiovascular, endocrine, respiratory, and urinary systems maintain homeostasis.
- Predict factors or situations that lead to respiratory or metabolic acidosis or alkalosis.
Sources of Acid Production
- Small amounts of acidic substances in food; mostly H+ is a byproduct of metabolism.
- Breakdown of phosphorus-containing proteins releases phosphoric acid into extracellular fluid (ECF).
- Lactic acid from anaerobic glucose respiration.
- Fatty acids and ketone bodies from fat metabolism.
- H+ is liberated when CO2 is converted to HCO3- in blood.
Acid-Base Regulation Mechanisms
- Chemical buffer systems (first line of defense, rapid, acts within 1-3 minutes).
- Brain stem respiratory centers (rapid, first line of defense, acts within 1-3 minutes).
- Renal mechanisms (most potent, require hours to days to effect pH changes).
Chemical Buffer Systems
-
Chemical buffers: One or more compounds resisting pH changes when a strong acid or base is added.
- Bind H+ if pH drops; release H+ if pH increases.
-
Bicarbonate buffer system: Mixture of H2CO3 (weak acid) and salts of HCO3- (weak base), major ECF buffer.
-
Phosphate buffer system: Dihydrogen phosphate (H2PO4-), a weak acid, and monohydrogen phosphate (HPO42-), a weak base.
-
Protein buffer system: Intracellular proteins, most powerful buffers, plasma proteins, act as both weak acid and weak base, influenced by changes in pH.
Physiological Buffering Systems
- Respiratory and renal systems regulate the amount of acid or base in the body, operate more slowly than chemical buffer systems, and have more capacity than chemical buffers.
Acid-Base Imbalances
- Chemical buffers cannot eliminate excess acids or bases from the body; however, physiological (respiratory and renal) buffers can.
- Lungs eliminate volatile carbonic acid by eliminating CO2.
- Kidneys eliminate nonvolatile acids (phosphoric, uric, lactic, and ketones) and regulate alkaline substances.
- Respiratory and renal systems compensate for imbalances by other respective organs.
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