chapter 9 patho
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Questions and Answers

What are the clinical manifestations of acidosis?

  • Coma and multiple organ failure (correct)
  • Nausea and dizziness
  • Anemia and hypertension
  • Hypoglycemia and tachycardia

Which system reacts within seconds to changes in hydrogen ion concentration?

  • Respiratory buffer system
  • Plasma buffer system (correct)
  • Renal buffer system
  • Intracellular buffer system

What substances are referred to as amphoteric?

  • Proteins and lipids
  • Carbohydrates and nucleic acids
  • Proteins and nucleic acids (correct)
  • Fats and carbohydrates

Which substance, when added to parenteral nutrition, may lead to metabolic acidosis?

<p>Hydrochloric acid (C)</p> Signup and view all the answers

Which two cations play a role in the regulation of acid-base balance?

<p>Hydrogen and potassium (C)</p> Signup and view all the answers

What causes an increased production of nonvolatile acids?

<p>Fasting and ketoacidosis (B)</p> Signup and view all the answers

What is the buffer system that responds to moment-to-moment changes to retain pH in the narrow range necessary for optimal cell function?

<p>Protein buffer system (B)</p> Signup and view all the answers

What is the treatment for HIV that is caused by nucleoside analogue reverse transcriptase (NRTIs)?

<p>Highly active antiretroviral therapy (HAART) (A)</p> Signup and view all the answers

What is a common alteration seen in conditions involving salt loss, hypokalemia, and hypochloremia?

<p>Renal Tubulopathy (D)</p> Signup and view all the answers

What type of nutrition provides all the required nutrients through an IV line?

<p>Total parenteral nutrition (TPN) (B)</p> Signup and view all the answers

What causes a decrease in pH when potassium moves into tubular cells in exchange for which substance?

<p>$Na^+$ (C)</p> Signup and view all the answers

Which substances are known to donate hydrogen ions?

<p>$HCO_3^-$ (B)</p> Signup and view all the answers

What is the weak acid in the bicarbonate buffer system?

<p>H2CO3 (C)</p> Signup and view all the answers

Which clinical manifestations are associated with Mild/HAART acidosis?

<p>Nausea and vomiting (C)</p> Signup and view all the answers

What is the buffer system that reacts within minutes to excrete CO2 through a change in respiratory rate?

<p>Respiratory (C)</p> Signup and view all the answers

In Salt-loosing tubulopathy with secondary hyperaldosteronism (Bartter Syndrome), what ions are involved in the development of metabolic alkalosis?

<p>Decreased H ions, increased HCO3 ions, loss of Cl ions (A)</p> Signup and view all the answers

What diuretic is used to prevent the reabsorption of sodium?

<p>Thiazide diuretic (B)</p> Signup and view all the answers

What is the clinical measurement used to determine the acid-base ratio?

<p>pH (C)</p> Signup and view all the answers

Which buffer system reacts within hours to days through the production, absorption, and excretion of acids, bases, and ions?

<p>Renal buffer system (D)</p> Signup and view all the answers

In metabolic acidosis, what is the lab finding for HCO3 levels?

<p>&lt;24 mEq/L (A)</p> Signup and view all the answers

Which substance moving into the cell pushes potassium out of the cell, leading to an increase in pH?

<p>Hydrogen (D)</p> Signup and view all the answers

What contributes to the development of metabolic acidosis?

<p>Increased acid secretion by kidneys (C)</p> Signup and view all the answers

Which altered acid-base balance is commonly involved in renal tubulopathy?

<p>Metabolic alkalosis (A)</p> Signup and view all the answers

What is the main buffering system that responds to moment-to-moment changes to retain pH for optimal cell function?

<p>Proteins (D)</p> Signup and view all the answers

Which alteration is common in conditions involving salt loss, hypokalemia, and hypochloremia?

<p>Metabolic acidosis (B)</p> Signup and view all the answers

What is the weak base involved in the bicarbonate buffer system?

<p>NH3 (C)</p> Signup and view all the answers

Which treatment is used for renal tubulopathy that involves the sparing of potassium?

<p>Spironolactone (D)</p> Signup and view all the answers

What is the cause of metabolic alkalosis resulting from an excess of HCO3 in the plasma?

<p>Increased bicarbonate levels (B)</p> Signup and view all the answers

Which element moving into tubular cells results in a decrease in pH through an exchange process?

<p>Potassium for Sodium (B)</p> Signup and view all the answers

What lab findings are commonly associated with metabolic alkalosis?

<p>Bicarbonate levels greater than 31mEq/L (D)</p> Signup and view all the answers

Which of the following substances are used in treating renal tubulopathy?

<p>Potassium-Sparing Diuretics (A)</p> Signup and view all the answers

What causes an increase in the production of nonvolatile acids?

<p>Fasting (B)</p> Signup and view all the answers

Which of the following is a common symptom of metabolic acidosis?

<p>Coma (C)</p> Signup and view all the answers

What substances are used in determining the anion gap?

<p>Sodium, Chloride, Bicarbonate (C)</p> Signup and view all the answers

Which system is responsible for eliminating hydrogen ions and conserving bicarbonate?

<p>Renal Buffer System (C)</p> Signup and view all the answers

What is the buffer system that reacts within hours to days through the production, absorption, and excretion of acids, bases, and ions?

<p>Renal (D)</p> Signup and view all the answers

Excessive chloride reabsorption in the kidneys can lead to an increase in which electrolyte when infused with sodium chloride?

<p>Chloride (C)</p> Signup and view all the answers

Which altered acid-base balance is commonly associated with renal tubulopathy?

<p>Metabolic alkalosis (A)</p> Signup and view all the answers

What is the primary lab finding for bicarbonate (HCO3) levels in metabolic acidosis?

<p>&lt;24 mEq/L (B)</p> Signup and view all the answers

Which prostaglandin inhibitor is commonly used in treating renal tubulopathy?

<p>Indomethacin (D)</p> Signup and view all the answers

What is the major measured cation and anion calculation used to assess acid-base balance?

<p>Anion gap calculation (B)</p> Signup and view all the answers

What is the indication of acid-base balance provided by the anion gap in plasma?

<p>Decreased chloride ions (D)</p> Signup and view all the answers

Which buffer system reacts within minutes to excrete carbon dioxide through a change in respiratory rate?

<p>Carbonic acid-bicarbonate buffer system (A)</p> Signup and view all the answers

What are the clinical manifestations associated with Mild/HAART acidosis?

<p>Muscle weakness and paresthesia (C)</p> Signup and view all the answers

Which diuretic is commonly used to prevent the reabsorption of sodium?

<p>Thiazide diuretic (A)</p> Signup and view all the answers

In the context of renal tubulopathy treatment, what ions are involved in the development of metabolic alkalosis?

<p>Decreased chloride ions and increased bicarbonate ions (C)</p> Signup and view all the answers

Which system reacts within seconds to changes in hydrogen ion concentration to retain pH for optimal cell function?

<p>Respiratory buffer system (C)</p> Signup and view all the answers

What is the weak acid involved in the bicarbonate buffer system?

<p>$H_2CO_3$ (D)</p> Signup and view all the answers

What is the primary lab finding indicative of metabolic alkalosis?

<p>Increased HCO3 ions (B)</p> Signup and view all the answers

Which condition is associated with symptoms like nausea, vomiting, abdominal discomfort, weight loss, and hepatic steatosis?

<p>Metabolic acidosis (B)</p> Signup and view all the answers

Which family of disorders includes Gitelman Syndrome and Bartter Syndrome?

<p>Familial hypokalemia-hypomagnesemia (D)</p> Signup and view all the answers

What is the buffer system that reacts within minutes to excrete CO2 through changes in respiratory rate?

<p>Respiratory system (B)</p> Signup and view all the answers

Which diuretic is specifically used to prevent the reabsorption of sodium?

<p>Loop diuretics (A)</p> Signup and view all the answers

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