Acepromazine Flashcards
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Questions and Answers

What class of drug is Acepromazine?

Phenothiazine

Is Acepromazine a controlled drug?

False

Is Acepromazine water soluble?

True

Where is Acepromazine metabolized?

<p>Liver</p> Signup and view all the answers

What types of effects does Acepromazine have?

<p>All of the above</p> Signup and view all the answers

In which animals is Acepromazine approved?

<p>Dogs, cats and horses</p> Signup and view all the answers

What are the injection routes for Acepromazine?

<p>All of the above (Must be IV in horses)</p> Signup and view all the answers

Is there a reversal agent currently available for Acepromazine?

<p>False</p> Signup and view all the answers

What are some adverse effects of Acepromazine?

<p>Hypotension, bradycardia, reduction of seizure threshold, decreased PCV, dry mouth, penile prolapse in horses.</p> Signup and view all the answers

What are the other significant characteristics of Acepromazine?

<p>Blocks dopamine and histamine receptors, crosses placental barrier slowly, higher doses increase hypotension but not sedation.</p> Signup and view all the answers

In which patients is Acepromazine contraindicated?

<p>Patients with liver and kidney damage, geriatric patients, neonates, and patients with hypotension or seizure history.</p> Signup and view all the answers

The dose range for Acepromazine is ____ mg/kg.

<p>0.05-0.1</p> Signup and view all the answers

Study Notes

Acepromazine Overview

  • Acepromazine belongs to the phenothiazine class of drugs.
  • It is not classified as a controlled substance.
  • The drug is water soluble, facilitating administration.

Metabolism and Approved Use

  • Acepromazine is metabolized by the liver.
  • Approved for use in dogs, cats, and horses.

Administration Routes

  • Can be administered via IV, IM, SQ, or orally.
  • For horses, intravenous (IV) administration is mandatory.

Effects and Safety

  • No reversal agent is currently available for Acepromazine.
  • Common adverse effects include:
    • Hypotension leading to decreased body temperature.
    • Bradycardia and reduction in seizure threshold.
    • Decreased packed cell volume (PCV) and dry mouth.
    • Penile prolapse may occur in large animals like horses.
    • Sedative effects can be diminished by sufficient patient stimulation.

Pharmacology and Usage

  • Acepromazine acts by blocking dopamine and histamine receptors.
  • It crosses the placental barrier slowly.
  • Higher doses may increase hypotension without enhancing sedation.
  • It can be combined with opioids to provide sedation and analgesia for minor procedures.
  • Used alone or in combination as a preanesthetic to reduce the dose of general anesthetics needed and improve induction and recovery processes.

Contraindications and Dosing

  • Contraindicated in:
    • Patients with liver and kidney damage or disease.
    • Geriatric patients, neonates, and those presenting with hypotension.
    • Patients with a history of seizures.
  • Recommended dose range is between 0.05-0.1 mg/kg.

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Description

Test your knowledge about Acepromazine with these flashcards. This quiz covers important details including its classification, properties, and administration routes in veterinary contexts. Perfect for students and professionals in animal health fields.

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