Podcast
Questions and Answers
Which of the following is true about ABO antigens?
Which of the following is true about ABO antigens?
- They are modified by the addition of two types of terminal sugar residues
- They are only expressed on red blood cells
- They are encoded by three alleles of the same gene
- They are carbohydrates on membrane glycoproteins or glycosphingolipids (correct)
Which blood group individuals express both terminal sugars on different glycolipid or glycoprotein molecules?
Which blood group individuals express both terminal sugars on different glycolipid or glycoprotein molecules?
- Blood group O
- Blood group B
- Blood group A
- Blood group AB (correct)
Which individuals make both anti-A and anti-B antibodies?
Which individuals make both anti-A and anti-B antibodies?
- Blood group B individuals
- Blood group A individuals
- Blood group O individuals (correct)
- Blood group AB individuals
Which type of antibodies are largely specific for A or B antigens?
Which type of antibodies are largely specific for A or B antigens?
What is the result of a severe transfusion reaction?
What is the result of a severe transfusion reaction?
What is the main cause of hemolytic disease of the fetus and newborn?
What is the main cause of hemolytic disease of the fetus and newborn?
What is the purpose of HLA matching in hematopoietic stem cell transplantation?
What is the purpose of HLA matching in hematopoietic stem cell transplantation?
Study Notes
ABO Antigens
- ABO antigens are responsible for the ABO blood group system.
Blood Group Antigens
- Individuals with AB blood group express both terminal sugars on different glycolipid or glycoprotein molecules.
Antibody Production
- Individuals with O blood group make both anti-A and anti-B antibodies.
Antibody Specificity
- Naturally occurring anti-A and anti-B antibodies are largely specific for A or B antigens.
Transfusion Reactions
- A severe transfusion reaction results in intravascular hemolysis, which can lead to kidney failure, shock, and even death.
Hemolytic Disease
- The main cause of hemolytic disease of the fetus and newborn is ABO incompatibility between the mother and fetus.
HLA Matching
- The purpose of HLA matching in hematopoietic stem cell transplantation is to reduce the risk of graft-versus-host disease and improve transplant outcomes.
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Description
Test your knowledge on ABO antigens and blood transfusion in this quiz. Learn about the importance of blood group compatibility and the barriers to successful transfusion.
