7 Questions
Which of the following is true about ABO antigens?
They are carbohydrates on membrane glycoproteins or glycosphingolipids
Which blood group individuals express both terminal sugars on different glycolipid or glycoprotein molecules?
Blood group AB
Which individuals make both anti-A and anti-B antibodies?
Blood group O individuals
Which type of antibodies are largely specific for A or B antigens?
IgM
What is the result of a severe transfusion reaction?
Systemic inflammatory response
What is the main cause of hemolytic disease of the fetus and newborn?
RhD-negative mother
What is the purpose of HLA matching in hematopoietic stem cell transplantation?
To prevent rejection of transplanted stem cells by NK cells
Study Notes
ABO Antigens
- ABO antigens are responsible for the ABO blood group system.
Blood Group Antigens
- Individuals with AB blood group express both terminal sugars on different glycolipid or glycoprotein molecules.
Antibody Production
- Individuals with O blood group make both anti-A and anti-B antibodies.
Antibody Specificity
- Naturally occurring anti-A and anti-B antibodies are largely specific for A or B antigens.
Transfusion Reactions
- A severe transfusion reaction results in intravascular hemolysis, which can lead to kidney failure, shock, and even death.
Hemolytic Disease
- The main cause of hemolytic disease of the fetus and newborn is ABO incompatibility between the mother and fetus.
HLA Matching
- The purpose of HLA matching in hematopoietic stem cell transplantation is to reduce the risk of graft-versus-host disease and improve transplant outcomes.
Test your knowledge on ABO antigens and blood transfusion in this quiz. Learn about the importance of blood group compatibility and the barriers to successful transfusion.
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