98 Questions
Process of antibody Production
Sensitization
Acts as a potent vasoconstrictor and causes contraction of bronchial smooth muscle.
Serotonin
Chemical mediators that initiate the inflammatory response. Cause smooth muscle contraction, bronchial constriction, mucus secretion in the airways, and the typical wheal-and-flare reactions of the skin.
Leukotriene
Can be obtained from blood samples or smears of secretions. A level greater than 5% to 10% is considered abnormal and may be found in patients with allergic disorders .
Complete blood count with differential
Results from a rapid release of IgE-mediated chemicals, which can induce a severe, life-threatening reaction
Anaphylaxis
Aka allergy vaccine therapy, involves the administration of gradually increasing quantities of specific allergens to the patient until a dose is reached that is effective in reducing disease severity from natural exposure.
allergen immunotherapy
The most common method of treatment which consists of the serial injection of one or more antigens that are selected in each particular case on the basis of skin testing.
subcutaneous immunotherapy
This acts as a cushion and lubricant
Synovial Fluid
Involves the deeper layers of the skin, resulting in more diffuse swelling rather than the discrete lesions characteristic of hives.
Angioedema
Uric acid deposits; develop in cartilage tissue, tendons, and soft tissues.
Tophi
_________ destroys cartilage and erodes the bone.
Pannus
is a blood test that that can show if you have inflammation in your body.
erythrocyte sedimentation rate
Prevent inflammation and joint damage; immunosuppresant.
DMARD Therapy
A chronic rash with erythematous papules or plaques and scaling and can cause scarring and pigmentation changes.
Discoid rash
Occurs due to a buildup of antibodies and immune complexes that cause damage to the nephrons.
nephritis
Hardening/stiffening of an artery related to presence of atheromal plaque.
Atherosclerosis
Approximately two thirds of body fluid is in the ICF compartment
Intracellular space
Approximately one third is in the ECF compartment .
Extracellular space
Electrolytes help:
• Balance the amount of water in your body • Balance your body's acid/base (pH) level • Move nutrients into your cells • Move wastes out of your cells • Make sure that your nerves, muscles, the heart, and the brain work.
Major cation in the ECF
Sodium
Major cation in the ICF
Potassium
Major anion ion the ECF
Chloride
Combination of fluids and electrolytes
Plasma
Movement of fluid from an area of lower solute concentration to an area of higher solute concentration with eventual equalization of the solute concentrations.
Osmosis
Movement of solutes from an area of greater concentration to an area of lesser concentration, leading ultimately to equalization of the solute concentrations.
Diffusion
A membrane that allows certain molecules or ions to pass through; exchange of fluid
Semipermeable membrane
is the ability of all solutes to cause an osmotic driving force that promotes water movement from one compartment to another.
Tonicity
Movement of water and solutes occurs from an area of high hydrostatic pressure to an area of low hydrostatic pressure.
Filtration
By product / waste product of muscle
Creatinine
The usual daily urine volume in the adult.
30 - 60 / 1 hr or 0.5 - 1 ml/kg/hr
Major functions in maintaining normal fluid balance:
• Regulation of ECF volume and osmolality by selective retention and excretion of body fluids • Regulation of normal electrolyte levels in the ECF by selective electrolyte retention and excretion • Regulation of pH of the ECF by retention of hydrogen ions • Excretion of metabolic wastes and toxic substances.
This manufactures ADH, which is stored in the posterior pituitary gland and released as needed to conserve water.
Hypothalamus
a mineralocorticoid secreted by the zona glomerulosa (outer zone) of the adrenal cortex, has a profound effect on fluid balance.
Aldosterone
embedded in the thyroid gland, regulate calcium and phosphate balance by means of parathyroid hormone (PTH).
Parathyroid glands
This influences bone reabsorption, calcium absorption from the intestines, and calcium reabsorption from the renal tubules.
parathyroid hormone (PTH)
Fight and flight responses
Glucocortisoid
It occurs when water and electrolytes are lost in the same proportion.
Hypovolemia / Fluid Volume Deficit
Clinical manifestations of hypovolemia
Acute weight loss, decreased skin turgor, dizziness, weakness, thirst, confusion, sunken eyes, nausea
Contains waste products, electrolyte; The normal id 1.005 - 1.030
Urine specific Gravity
Fluids to administer in hypovolemia
Isotonic electrolyte solutions such as Lactated Ringer Solution, 0.9% sodium chloride
Nursing Management for Hypovolemia
• The nurse observes for a weak, rapid pulse and orthostatic hypotension. • A decrease in body temperature often accompanies FVD, unless there is a concurrent infection. • Assessing skin turgor • Assessing tongue turgor: Additional longitudinal furrows and the tongue is smaller because of fluid loss.
Refers to an isotonic expansion of the ECF caused by the abnormal retention of water and sodium in approximately the same proportions in which they normally exist in the ECF.
Hypervolemia / Fluid volume Excess
Clinical manifestations of hypervolemia
peripheral edema and ascites, crackles, SOB, bounding pulse and cough, increase urine output
This block sodium reabsorption in the distal tubule, where only 5% to 10% of filtered sodium is reabsorbed. Ex. hydrochlorothiazide (Microzide)
Thiazide diuretics
such as furosemide (Lasix) or torsemide (Demadex), can cause a greater loss of both sodium and water because they block sodium reabsorption in the ascending limb of Henle loop, where 20% to 30% of filtered sodium is normally reabsorbed.
Loop Diuretics
Used when renal function is so severely impaired that pharmacologic agents cannot act efficiently; Hemodialysis or peritoneal dialysis may be used to remove nitrogenous wastes and control potassium and acid–base balance, and to remove sodium and fluid.
Dialysis
contain potassium and must therefore be used cautiously by patients taking potassium-sparing diuretics
Salt substitutes
Nursing management for Hypervolemia
Measures I&O at regular intervals to identify excessive fluid retention. Weighed daily. Breath sounds Degree of edema. Evaluated on a scale of 1+ (minimal) to 4+ (severe). Measuring the extremity
a type of edema in which fluid accumulates in the peritoneal cavity; it results from nephrotic syndrome and cirrhosis.
Ascites
Serum sodium level that is less than 135 mEq/L (135 mmol/L).
Hyponatremia
Excessive ADH activity, with water retention and dilutional hyponatremia, and inappropriate urinary excretion of sodium in the presence of hyponatremia. Key word: Soak Inside
SIADH
Clinical Manifestations for Hyponatremia
anorexia, nausea and vomiting, headache, lethargy, dizziness, seizures, edema, weight gain
Pharmacologic management for hyponatermia
Arginine vasopressin (AVP)receptor antagonists: IV conivaptan hydrochloride (Vaprisol)
Serum sodium level higher than 145 mEq/L (145 mmol/L). It can occur in patients with normal fluid volume or in those with FVD or FVE.
Hypernatremia
Pathophysiology of Hypernatremia
Fluid deprivation in patients who cannot respond to thirst (Very old, very young, and cognitively impaired) Administration of hypertonic enteral feedings without adequate water supplements. Watery diarrhea Greatly increased insensible water loss (e.g., hyperventilation, burns) Diabetes insipidus IV administration of hypertonic saline
Clinical manifestations of Hypernatermia
thirst, restlessness, simple partial or tonic-clonic seizures, twitching
Medical management for Hypernatremia
Gradual lowering of the serum sodium level by the infusion of a hypotonic electrolyte solution (e.g., 0.3% sodium chloride) or an isotonic nonsaline solution (e.g., dextrose 5% in water [D5W]). Diuretics also may be prescribed to treat the sodium gain. Desmopressin acetate, a synthetic ADH, may be prescribed to treat diabetes insipidus if it is the cause of hypernatremia
Nursing Management for Hypernatremia
Assess for abnormal losses of water or low water intake Assess for large gains of sodium (diet, OTC medications,etc.) Assess for changes in behavior, such as restlessness, disorientation, and lethargy Prevent hypernatremia by providing oral fluids at regular intervals, particularly in patients who are unable to perceive or respond to thirst.
Binge - eating
Bulimia
Patho of Hypokalemia
Hyperaldosteronism increases renal potassium wasting and can lead to severe potassium depletion. Patients with persistent insulin hypersecretion because insulin promotes the entry of potassium into skeletal muscle and hepatic cells
An elevated ___________ is specific to hypokalemia.
U wave
A wave that can be seen for atrial contraction
P wave
A wave that can be seen fir ventricular contraction
Q, R, S Complex
A wave that can be seen for ventricular depolarization (relaxation)
T-Wave
Diuretic that should be avoided in Hypokalemia
Potassium Sparring diuretic
Serum potassium level greater than 5 mEq/L [5 mmol/L.
Hyperkalemia
Pathophysiology of Hyperkalemia
Decreased renal excretion of potassium. Rapid administration of potassium. Movement of potassium from the ICF compartment to the ECF compartment. Commonly seen in patients with untreated kidney injury (AKI or CKD) Patients with hypoaldosteronism or Addison disease Extensive tissue trauma (burns and crushing injuries).
Clinical manifestations for Hyperkalemia
muscle weakness, intestinal colic, cramps, abdominal distention,
ECG for Hyperkalemia
Tall tented or Peaked T wave, Wide PR interval, wide QRS duration
Emergency Pharmacologic Therapy for hyperkalemia
Ca gluconate Beta-2 agonists IV administration of regular insulin and a hypertonic dextrose solution Peritoneal dialysis or Hemodialysis.
Nursing management for Hyperkalemia
When measuring vital signs, an apical pulse should be taken. The presence of paresthesias and GI symptoms such as nausea and intestinal colic are noted. Encouraging the patient to adhere to the prescribed potassium restriction. Potassium-rich foods to be avoided. Administer and monitor potassium solutions closely.
This inhibits the Calcium in the bone.
Calcitonin
Acts as anticoagulant; eliminates calcium
Citrated blood
Serum calcium is controlled by PTH and calcitonin. As ionized serum calcium decreases, the parathyroid glands secrete PTH.
• Increases calcium absorption from the GI tract • Increases calcium reabsorption from the renal tubule • Releases calcium from the bone.
is a symptom that involves involuntary muscle contractions and overly stimulated peripheral nerves.
Tetany
Twitching of muscles enervated by the facial nerve
Chvostek Sign
ECG for hypocalcemia
A prolonged QT interval
Non vesicant fluid; Can cause tissue and cell damage
Infiltration
Vesicant fluid; Irritating; cellulitis and necrosis
Extravasation
Nutritional therapy for hypocalcemia
Vitamin D therapy Increasing the dietary intake of calcium to at least 1000 to 1500 mg/day in the adult is recommended. Calcium supplements must be given in divided doses of no higher than 500 mg to promote calcium absorption. Calcium-containing foods include milk products; green, leafy vegetables; canned salmon; canned sardines; and fresh oysters.
Serum calcium value greater than 10.2 mg/dL [2.6 mmol/L]).
Hypercalcemia
Pathophysiology of hypercalcemia
Hyperparathyroidism Excessive PTH secretion associated with hyperparathyroidism causes increased release of calcium from the bones and increased intestinal and renal absorption of calcium. Bone mineral is lost during immobilization
Clinical Manifestation of hyercalcemia
Muscle weakness Constipation Nausea and Vomiting Polyuria and Polydipsia DHN Hypoactive DTR Calcium stones Shortened ST segment and QT interval, bradycardia
Most abundant an ion in intracellular
Phosphate
Serum magnesium concentration (1.3 mg/dL [0.62 mmol/L]) and is frequently associated with hypokalemia and hypocalcemia.
hypomagnesemia
Pathophysiology if hypomagnasemia
Any disruption in small bowel function Chronic alcohol abuse:
Clinical Manifestations of hypomagnasemia
Neuromuscular irritability. Tetany: Trousseau sign and Chvostek sign Insomnia Mood changes Increased DTR ECG: PVCs, flat or inverted T waves, depressed ST segment, prolonged PR interval, and widened QRS
Medical Management for hypomagnasemia
Mild magnesium deficiency can be corrected by diet alone. Principal dietary sources of magnesium include green leafy vegetables, nuts, seeds, legumes, whole grains, seafood, peanut butter, and cocoa. Overt symptoms of hypomagnesemia are treated with parenteral administration of magnesium. Vital signs must be assessed frequently during magnesium administration to detect changes in cardiac rate or rhythm, hypotension, and respiratory distress.
Serum magnesium level higher than 3.0 mg/dL [1.25 mmol/L].
Hypermagnasemia
Clinical Manifestations of hypermagnasemia
Flushing Hypotension Muscle weakness Drowsiness Hypoactive reflexes Depressed respiration ECG: Prolonged PR interval and QRS, peaked T waves
Formula for Flow rate
Volume (ml)
Time (hrs)
ml per hour
Formula for Droprate
Volume (ml) divide Time (hrs) X Drop factor = IV flow rate per minute (gtt/min)
Immunosuppressive Agents
Methotrexate, azathioprine, cyclophosphamide
Scleroderma
An autoimmune disorder that involves hardening and tightening of the skin. It may also cause problems in the blood vessels, internal organs and digestive tract.
CREST syndrome
Calcinosis, Raynaud’s phenomenon, Esophageal Dysfunction, Sclerodactyly, Telangiectasis
group of diseases that are termed idiopathic inflammatory myopathies
Polymyositis
related condition, is most commonly identified by an erythematous smooth or scaly lesion found over the joint surface, which often occurs prior to symptoms of weakness.
Dermatomyositis
Diagnostic procedure to assess the health of muscles and the nerve cells. Can reveal nerve dysfunction, muscle dysfunction or problems with nerve-to-muscle signal transmission.
Electromyography
Practice exam for MEDSURG
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free