Tumor Treatment and 5-Fluorouracil MOA
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Questions and Answers

What is the main mode of action of 5-Fluorouracil (5-FU)?

  • Inhibition of thymidylate synthase (TS) (correct)
  • Incorporation of FdUTP into RNA resulting in alteration in RNA processing
  • Activation of thymineless death
  • Incorporation of FUTP into DNA resulting in inhibition of DNA synthesis
  • What are the possible treatments for tumors according to the text?

  • Surgery and systemic chemotherapy only
  • Local radiation and systemic chemotherapy only
  • Surgery and local radiation only
  • Surgery, local radiation, and/or systemic chemotherapy (correct)
  • What is the mechanism of action of most anticancer antibiotics?

  • Inhibition of DNA topoisomerases (correct)
  • Production of free radicals
  • Interference with cell division
  • Prevention of DNA replication
  • Anticancer antibiotics are isolated from?

    <p>Streptomyces</p> Signup and view all the answers

    What makes bleomycin different from other anticancer antibiotics in terms of its mode of action?

    <p>It has a cell cycle-specific action</p> Signup and view all the answers

    How do anticancer antibiotics like doxorubicin and bleomycin affect DNA?

    <p>They intercalate with DNA</p> Signup and view all the answers

    What is the main mechanism of action of Doxorubicin?

    <p>Causing single- and double-strand DNA breaks</p> Signup and view all the answers

    Which type of cancer is NOT listed as a use for Doxorubicin?

    <p>Prostate cancer</p> Signup and view all the answers

    How is Doxorubicin metabolized when administered intravenously?

    <p>inactivated in the GIT</p> Signup and view all the answers

    What is a potential adverse effect of Doxorubicin administration?

    <p>Extravasation</p> Signup and view all the answers

    What is the main adverse effect of Doxorubicin administration?

    <p>Cardiotoxicity</p> Signup and view all the answers

    How is the cardiotoxicity of Doxorubicin reduced?

    <p>Use of iron chelator (dexrazoxane)</p> Signup and view all the answers

    Which organ is NOT affected by Doxorubicin due to its inability to penetrate it?

    <p>Central Nervous System (CNS)</p> Signup and view all the answers

    How is Doxorubicin primarily excreted from the body?

    <p>Excretion through bile</p> Signup and view all the answers

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