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Tumor Treatment and 5-Fluorouracil MOA

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Questions and Answers

What is the main mode of action of 5-Fluorouracil (5-FU)?

Inhibition of thymidylate synthase (TS) (correct)

Incorporation of FdUTP into RNA resulting in alteration in RNA processing

Activation of thymineless death

Incorporation of FUTP into DNA resulting in inhibition of DNA synthesis

What are the possible treatments for tumors according to the text?

Surgery and systemic chemotherapy only

Local radiation and systemic chemotherapy only

Surgery and local radiation only

Surgery, local radiation, and/or systemic chemotherapy (correct)

What is the mechanism of action of most anticancer antibiotics?

Inhibition of DNA topoisomerases (correct)

Production of free radicals

Interference with cell division

Prevention of DNA replication

Anticancer antibiotics are isolated from?

Streptomyces (B) Signup and view all the answers

What makes bleomycin different from other anticancer antibiotics in terms of its mode of action?

It has a cell cycle-specific action (A) Signup and view all the answers

How do anticancer antibiotics like doxorubicin and bleomycin affect DNA?

They intercalate with DNA (B) Signup and view all the answers

What is the main mechanism of action of Doxorubicin?

Causing single- and double-strand DNA breaks (D) Signup and view all the answers

Which type of cancer is NOT listed as a use for Doxorubicin?

Prostate cancer (A) Signup and view all the answers

How is Doxorubicin metabolized when administered intravenously?

inactivated in the GIT (C) Signup and view all the answers

What is a potential adverse effect of Doxorubicin administration?

Extravasation (B) Signup and view all the answers

What is the main adverse effect of Doxorubicin administration?

Cardiotoxicity (C) Signup and view all the answers

How is the cardiotoxicity of Doxorubicin reduced?

Use of iron chelator (dexrazoxane) (D) Signup and view all the answers

Which organ is NOT affected by Doxorubicin due to its inability to penetrate it?

Central Nervous System (CNS) (A) Signup and view all the answers

How is Doxorubicin primarily excreted from the body?

Excretion through bile (A) Signup and view all the answers