Lecture 19 – Protein Structure: Amnio acids and sequence
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Questions and Answers

How many commonly found amino acids are there in proteins?

  • 18
  • 20 (correct)
  • 22
  • 24

Which type of amino acids are considered hydrophilic?

  • Nonpolar amino acids
  • Charged and polar amino acids (correct)
  • Aromatic amino acids
  • Aliphatic amino acids

What characterizes positively charged (basic) amino acids?

  • Fully protonated at low pH (correct)
  • Fully deprotonated at high pH
  • Have no ionizable groups
  • Are always hydrophobic

What does a low pKa value indicate about an acid?

<p>It is a strong acid. (A)</p> Signup and view all the answers

Which amino acid is known for its role in forming disulfide bonds?

<p>Cysteine (B)</p> Signup and view all the answers

What is the primary function of disulfide bonds in proteins?

<p>To stabilize protein structure (B)</p> Signup and view all the answers

What is the general structure of an amino acid?

<p>Amino group, carboxyl group, R group, hydrogen atom (A)</p> Signup and view all the answers

Which statement best describes hydrophobic amino acids?

<p>They are typically located in the interior of globular proteins. (C)</p> Signup and view all the answers

What is the term for a chain of two amino acids?

<p>Dipeptide (B)</p> Signup and view all the answers

How does the pH affect the ionization of amino acids?

<p>It determines the charge state of the amino acids. (D)</p> Signup and view all the answers

Which amino acid is known for providing flexibility in proteins?

<p>Glycine (A)</p> Signup and view all the answers

What is the significance of the pKa value in amino acids?

<p>It predicts the protonation state at a given pH. (C)</p> Signup and view all the answers

What type of bond forms between two cysteine residues?

<p>Disulfide bond (C)</p> Signup and view all the answers

Which amino acid has a side chain that can engage in hydrogen bonding due to its hydroxyl group?

<p>Tyrosine (A)</p> Signup and view all the answers

What is the backbone structure of a polypeptide?

<p>N-Cα-C-N-Cα-C (C)</p> Signup and view all the answers

What do we call the end of a polypeptide with a free amino group?

<p>N-terminal (B)</p> Signup and view all the answers

What happens to the thiol (-SH) group of cysteine in a hydrophobic environment?

<p>It remains uncharged and stable. (C)</p> Signup and view all the answers

Which of the following amino acids is classified as aromatic?

Signup and view all the answers

What is the significance of the Henderson-Hasselbalch equation in relation to amino acids?

<p>It predicts the pH of buffer solutions. (B)</p> Signup and view all the answers

What is the common name for a peptide composed of more than 50 amino acids?

<p>Polypeptide (B)</p> Signup and view all the answers

Which amino acid is known for its role in stabilizing alpha-helices in proteins?

<p>Proline (B)</p> Signup and view all the answers

What type of amino acids are typically found at the water/protein interface?

<p>Hydrophilic amino acids (B)</p> Signup and view all the answers

What is the role of polar amino acids in proteins?

<p>Engaging in hydrogen bonding (C)</p> Signup and view all the answers

Which amino acid's side chain is considered reactive due to its thiol group?

<p>Cysteine (B)</p> Signup and view all the answers

What is the first protein to be sequenced?

<p>Insulin (C)</p> Signup and view all the answers

How are amino acids represented in protein sequences?

<p>By their 1-letter or 3-letter codes (B)</p> Signup and view all the answers

What is the primary characteristic of aromatic amino acids?

<p>They have a ring structure. (B)</p> Signup and view all the answers

What happens to the charge of acidic amino acids at low pH?

<p>They become positively charged. (A)</p> Signup and view all the answers

What stabilizes the structure of proteins in an oxidizing environment?

<p>Disulphide bonds (C)</p> Signup and view all the answers

Which of the following statements is true about the sequencing of proteins?

<p>Proteins are often sequenced indirectly via DNA. (C)</p> Signup and view all the answers

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