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Lecture 19: Calcium Regulation & Metabolic Regulation
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Lecture 19: Calcium Regulation & Metabolic Regulation

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Questions and Answers

What is the primary function of food in the body?

  • To provide building blocks for the body's growth and repair (correct)
  • To provide energy for the body's functions (correct)
  • To absorb oxygen
  • To regulate body temperature
  • What is the primary characteristic of fat-soluble vitamins?

  • They are stored in the body's fat tissue (correct)
  • They have no specific function in the body
  • They are only found in plant-based foods
  • They are dissolved in bodily fluids
  • What is the primary function of vitamin A?

  • To aid in immune function
  • To facilitate blood clotting
  • To regulate calcium levels in the body
  • To act as a precursor molecule for the photopigment in the eye (correct)
  • What is the primary function of vitamin D?

    <p>To regulate calcium levels in the body</p> Signup and view all the answers

    What is the primary function of vitamin K?

    <p>To facilitate blood clotting</p> Signup and view all the answers

    What is the primary characteristic of water-soluble vitamins?

    <p>They are dissolved in bodily fluids</p> Signup and view all the answers

    What is the primary cause of scurvy?

    <p>A vitamin C deficiency</p> Signup and view all the answers

    What is the primary cause of rickets?

    <p>A vitamin D deficiency</p> Signup and view all the answers

    Which of the following is a major mineral?

    <p>Calcium</p> Signup and view all the answers

    What is the primary function of minerals in the body?

    <p>To regulate various bodily functions</p> Signup and view all the answers

    Food provides the body with energy for only muscle contractions and active transport.

    <p>False</p> Signup and view all the answers

    Vitamins are classified as macronutrients.

    <p>False</p> Signup and view all the answers

    Vitamin E is necessary for vision.

    <p>False</p> Signup and view all the answers

    Water-soluble vitamins are stored in the body's fat tissue.

    <p>False</p> Signup and view all the answers

    Folic acid is a fat-soluble vitamin.

    <p>False</p> Signup and view all the answers

    Minerals are only needed by the body in small quantities.

    <p>False</p> Signup and view all the answers

    Vitamin C is necessary for blood cell formation.

    <p>False</p> Signup and view all the answers

    Rickets is a deficiency of vitamin C.

    <p>False</p> Signup and view all the answers

    Iron is a major mineral.

    <p>False</p> Signup and view all the answers

    Calcium is a trace mineral.

    <p>False</p> Signup and view all the answers

    What is the primary role of calcium in muscle contraction?

    <p>It allows muscles to contract</p> Signup and view all the answers

    What happens to calcium levels in the blood during bone deposition?

    <p>They decrease</p> Signup and view all the answers

    What is the composition of the bone matrix?

    <p>Calcium, phosphate, and collagen</p> Signup and view all the answers

    What is the primary function of parathyroid hormone (PTH)?

    <p>To increase calcium levels in the blood</p> Signup and view all the answers

    What is the source of vitamin D?

    <p>Obtained from the diet, produced in small amounts in the body, and required for calcium absorption</p> Signup and view all the answers

    What is the effect of calcitonin on calcium levels in the blood?

    <p>It decreases calcium levels</p> Signup and view all the answers

    What is the role of osteoblasts and osteoclasts in bone remodeling?

    <p>Both osteoblasts and osteoclasts are involved in bone remodeling</p> Signup and view all the answers

    What is the function of calcium as a second messenger in signal transduction pathways?

    <p>It signals the release of neurotransmitters from neurons</p> Signup and view all the answers

    What is the effect of calcitonin on calcium and phosphate levels in the blood?

    <p>It decreases calcium and phosphate levels.</p> Signup and view all the answers

    Where is estrogen produced in females?

    <p>Ovaries</p> Signup and view all the answers

    What is the role of estrogen in bone health?

    <p>It stimulates bone growth and deposition.</p> Signup and view all the answers

    What is the condition characterized by porous bones and reduced bone density?

    <p>Osteoporosis</p> Signup and view all the answers

    What is the primary cause of osteoporosis in post-menopausal women?

    <p>Estrogen deficiency</p> Signup and view all the answers

    What is the effect of estrogen on growth plates during puberty?

    <p>It stimulates growth plate closure</p> Signup and view all the answers

    What is the outcome of decreased estrogen levels in older adults?

    <p>Osteoporosis</p> Signup and view all the answers

    What is the primary consequence of osteoporosis?

    <p>Increased risk of fractures</p> Signup and view all the answers

    Which of the following hormones stimulates bone deposition?

    <p>Estrogen</p> Signup and view all the answers

    Calcium is necessary for nerve impulse transmission.

    <p>False</p> Signup and view all the answers

    Bone resorption decreases calcium levels in the blood.

    <p>False</p> Signup and view all the answers

    Vitamin D is produced in the thyroid gland.

    <p>False</p> Signup and view all the answers

    Calcitonin increases calcium levels in the blood.

    <p>False</p> Signup and view all the answers

    The bone matrix is made of calcium, phosphate, and protein.

    <p>True</p> Signup and view all the answers

    Parathyroid hormone (PTH) decreases osteoclast activity.

    <p>False</p> Signup and view all the answers

    Calcium functions as a second messenger in signal transduction pathways and signals the release of hormones from neurons.

    <p>False</p> Signup and view all the answers

    Bones only provide structure and attachment points for muscles.

    <p>False</p> Signup and view all the answers

    Estrogen is produced by the pancreas in females.

    <p>False</p> Signup and view all the answers

    Calcitonin increases calcium and phosphate levels in the blood.

    <p>False</p> Signup and view all the answers

    Osteoporosis is characterized by an increase in bone density.

    <p>False</p> Signup and view all the answers

    Estrogen stimulates bone resorption.

    <p>False</p> Signup and view all the answers

    A decline in estrogen levels can lead to an increase in bone density.

    <p>False</p> Signup and view all the answers

    Osteoporosis is more common in young adults than older adults.

    <p>False</p> Signup and view all the answers

    Calcitonin inhibits bone deposition.

    <p>False</p> Signup and view all the answers

    Estrogen is produced indirectly in females.

    <p>True</p> Signup and view all the answers

    Osteoporosis is a condition characterized by an increase in the risk of fractures.

    <p>True</p> Signup and view all the answers

    What does the calorie amount on a nutrition label represent?

    <p>Total energy from all sources in the food</p> Signup and view all the answers

    What is the primary factor influencing basal metabolic rate (BMR)?

    <p>Body surface area and thyroid hormone secretion</p> Signup and view all the answers

    What happens when energy input exceeds energy expenditure?

    <p>Weight gain occurs</p> Signup and view all the answers

    Which hormone is released by the stomach when it's empty?

    <p>Ghrelin</p> Signup and view all the answers

    What is the role of leptin in energy balance?

    <p>Suppressing hunger and promoting satiety</p> Signup and view all the answers

    What is a possible consequence of extreme dieting on metabolic rate?

    <p>It lowers metabolic rate in the long term</p> Signup and view all the answers

    Which brain region regulates eating behavior?

    <p>Hypothalamus</p> Signup and view all the answers

    What is the primary function of CCK?

    <p>Suppressing hunger and promoting satiety</p> Signup and view all the answers

    What is the outcome of knocking out the leptin receptor or leptin gene in mice?

    <p>Decreased metabolic rate and weight gain</p> Signup and view all the answers

    What is the primary reason for the body's resistance to weight loss?

    <p>Homeostasis and the body's set point</p> Signup and view all the answers

    Calories listed on a nutrition label represent the amount of energy from fats only

    <p>False</p> Signup and view all the answers

    Metabolic rate measures energy expenditure per unit of volume

    <p>False</p> Signup and view all the answers

    Basal metabolic rate (BMR) is the metabolic rate during physical activity

    <p>False</p> Signup and view all the answers

    If energy input is equal to energy expenditure, weight loss occurs

    <p>False</p> Signup and view all the answers

    The body's set point makes it easy to gain or lose weight

    <p>False</p> Signup and view all the answers

    Ghrelin is released by the pancreas and suppresses hunger

    <p>False</p> Signup and view all the answers

    Insulin is released by the small intestine and promotes hunger

    <p>False</p> Signup and view all the answers

    Leptin is released by the hypothalamus and stimulates hunger

    <p>False</p> Signup and view all the answers

    Knocking out the leptin receptor or leptin gene leads to weight loss due to increased metabolism

    <p>False</p> Signup and view all the answers

    A study on The Biggest Loser contestants found that most regained weight

    <p>True</p> Signup and view all the answers

    Study Notes

    Why We Need to Eat

    • Food is a source of energy for the body, necessary for various activities such as movement, muscle contractions, and active transport.
    • Food provides building blocks for the body, including minerals, vitamins, and raw materials for making proteins, carbohydrates, nucleic acids, and other molecules.

    Vitamins and Minerals

    • Vitamins are small organic molecules needed by the body in smaller quantities, classified as micronutrients.
    • Minerals are inorganic molecules needed by the body, also classified as micronutrients.
    • Vitamins can be either fat-soluble (e.g., A, D, E, K) or water-soluble (e.g., B vitamins, folic acid, vitamin C).
    • Fat-soluble vitamins are hydrophobic and can be retained in the body's fat tissue.
    • Water-soluble vitamins are hydrophilic and dissolve in fluids, but tend not to be stored in the body and are cleared through the kidneys.

    Functions of Vitamins

    • Vitamin A is essential for vision, as it's a precursor molecule for the photopigment in the eye.
    • Vitamin D is important for calcium regulation and has other roles.
    • Vitamin E has various functions in the body.
    • Vitamin K is necessary for blood cell formation.
    • B vitamins, folic acid, and vitamin C have various functions in the body, including acting as coenzymes and being important for immune function.

    Vitamin Deficiencies

    • Scurvy is a vitamin C deficiency that can cause problems such as bleeding gums and bruising easily due to the importance of vitamin C in connective tissue production and immune function.
    • Rickets is a vitamin D deficiency that can lead to deformed bones in children due to the importance of vitamin D in calcium absorption and bone growth.

    Minerals

    • Major minerals include potassium, sodium, calcium, phosphorus, magnesium, and chloride.
    • Trace minerals, needed in very small quantities, include iron, zinc, copper, and others.
    • Minerals have various functions, such as acting as cofactors for enzymes, maintaining osmotic balance, and being involved in membrane potential and oxygen transport.
    • Iron is essential for oxygen transport.

    Why We Need to Eat

    • Food serves as a source of energy for the body, enabling various activities such as movement, muscle contractions, and active transport.
    • It provides building blocks for the body, including minerals, vitamins, and raw materials for producing proteins, carbohydrates, nucleic acids, and other molecules.

    Vitamins and Minerals

    • Vitamins are small organic molecules required by the body in small quantities, classified as micronutrients.
    • Minerals are inorganic molecules needed by the body, also classified as micronutrients.
    • Vitamins can be classified into two categories: fat-soluble (e.g., A, D, E, K) and water-soluble (e.g., B vitamins, folic acid, vitamin C).
    • Fat-soluble vitamins are hydrophobic and can be stored in the body's fat tissue.
    • Water-soluble vitamins are hydrophilic, dissolve in fluids, and tend not to be stored in the body, being cleared through the kidneys instead.

    Functions of Vitamins

    • Vitamin A is essential for vision, serving as a precursor molecule for the photopigment in the eye.
    • Vitamin D plays a crucial role in calcium regulation and has other functions.
    • Vitamin E has various functions in the body.
    • Vitamin K is necessary for blood cell formation.
    • B vitamins, folic acid, and vitamin C have various functions, including acting as coenzymes and being important for immune function.

    Vitamin Deficiencies

    • Scurvy is a vitamin C deficiency, leading to issues such as bleeding gums and bruising easily due to the importance of vitamin C in connective tissue production and immune function.
    • Rickets is a vitamin D deficiency, resulting in deformed bones in children due to the importance of vitamin D in calcium absorption and bone growth.

    Minerals

    • Major minerals include potassium, sodium, calcium, phosphorus, magnesium, and chloride.
    • Trace minerals, needed in very small quantities, include iron, zinc, copper, and others.
    • Minerals have various functions, such as acting as cofactors for enzymes, maintaining osmotic balance, and being involved in membrane potential and oxygen transport.
    • Iron is essential for oxygen transport.

    Why We Need to Eat

    • Food serves as a source of energy for the body, enabling various activities such as movement, muscle contractions, and active transport.
    • It provides building blocks for the body, including minerals, vitamins, and raw materials for producing proteins, carbohydrates, nucleic acids, and other molecules.

    Vitamins and Minerals

    • Vitamins are small organic molecules required by the body in small quantities, classified as micronutrients.
    • Minerals are inorganic molecules needed by the body, also classified as micronutrients.
    • Vitamins can be classified into two categories: fat-soluble (e.g., A, D, E, K) and water-soluble (e.g., B vitamins, folic acid, vitamin C).
    • Fat-soluble vitamins are hydrophobic and can be stored in the body's fat tissue.
    • Water-soluble vitamins are hydrophilic, dissolve in fluids, and tend not to be stored in the body, being cleared through the kidneys instead.

    Functions of Vitamins

    • Vitamin A is essential for vision, serving as a precursor molecule for the photopigment in the eye.
    • Vitamin D plays a crucial role in calcium regulation and has other functions.
    • Vitamin E has various functions in the body.
    • Vitamin K is necessary for blood cell formation.
    • B vitamins, folic acid, and vitamin C have various functions, including acting as coenzymes and being important for immune function.

    Vitamin Deficiencies

    • Scurvy is a vitamin C deficiency, leading to issues such as bleeding gums and bruising easily due to the importance of vitamin C in connective tissue production and immune function.
    • Rickets is a vitamin D deficiency, resulting in deformed bones in children due to the importance of vitamin D in calcium absorption and bone growth.

    Minerals

    • Major minerals include potassium, sodium, calcium, phosphorus, magnesium, and chloride.
    • Trace minerals, needed in very small quantities, include iron, zinc, copper, and others.
    • Minerals have various functions, such as acting as cofactors for enzymes, maintaining osmotic balance, and being involved in membrane potential and oxygen transport.
    • Iron is essential for oxygen transport.

    Calcium in the Body

    • Calcium plays crucial roles in maintaining bone health, signaling, muscle contraction, and blood clotting.
    • It functions as a second messenger in signal transduction pathways, signaling the release of neurotransmitters from neurons.
    • Calcium is necessary for muscle contraction, as its release into the cytoplasm allows muscles to contract.

    Calcium Regulation

    • Calcium levels in the blood are influenced by bone deposition, bone resorption, intestinal absorption, and kidney reabsorption and secretion.
    • Bone deposition reduces calcium levels in the blood by storing calcium in bones.
    • Bone resorption releases calcium into the blood, increasing calcium levels.

    Bones and Calcium

    • Bones provide structure, attachment points for muscles, and store calcium and phosphate.
    • The bone matrix is composed of calcium, phosphate, and collagen, providing hardness and strength to the bone.
    • Bone is dynamic, constantly changing and being remodeled by osteoblasts and osteoclasts.

    Hormonal Regulation

    • Calcium levels are regulated by parathyroid hormone (PTH), vitamin D, and calcitonin.
    • PTH is released in response to low calcium levels, stimulating osteoclast activity, promoting calcium reabsorption, and helping synthesize vitamin D.
    • Vitamin D is essential for calcium absorption, produced in the skin upon UV light exposure, and in the kidney.
    • Vitamin D stimulates calcium absorption, increasing calcium levels in the blood.
    • Calcitonin is released in response to high calcium levels, decreasing calcium and phosphate levels by stimulating bone deposition and inhibiting calcium and phosphate reabsorption.

    Hormonal Interaction

    • Estrogen is important for maintaining bone health, stimulating bone deposition, bone growth, and sealing growth plates during puberty.
    • A decline in estrogen levels can lead to osteoporosis.

    Osteoporosis

    • Osteoporosis is characterized by a loss of mineral and organic matrix, leading to reduced bone density and an increased risk of fractures.
    • It is common in older adults, particularly post-menopausal women, due to declining estrogen levels.

    Calcium in the Body

    • Calcium plays crucial roles in maintaining bone health, signaling, muscle contraction, and blood clotting.
    • It functions as a second messenger in signal transduction pathways, signaling the release of neurotransmitters from neurons.
    • Calcium is necessary for muscle contraction, as its release into the cytoplasm allows muscles to contract.

    Calcium Regulation

    • Calcium levels in the blood are influenced by bone deposition, bone resorption, intestinal absorption, and kidney reabsorption and secretion.
    • Bone deposition reduces calcium levels in the blood by storing calcium in bones.
    • Bone resorption releases calcium into the blood, increasing calcium levels.

    Bones and Calcium

    • Bones provide structure, attachment points for muscles, and store calcium and phosphate.
    • The bone matrix is composed of calcium, phosphate, and collagen, providing hardness and strength to the bone.
    • Bone is dynamic, constantly changing and being remodeled by osteoblasts and osteoclasts.

    Hormonal Regulation

    • Calcium levels are regulated by parathyroid hormone (PTH), vitamin D, and calcitonin.
    • PTH is released in response to low calcium levels, stimulating osteoclast activity, promoting calcium reabsorption, and helping synthesize vitamin D.
    • Vitamin D is essential for calcium absorption, produced in the skin upon UV light exposure, and in the kidney.
    • Vitamin D stimulates calcium absorption, increasing calcium levels in the blood.
    • Calcitonin is released in response to high calcium levels, decreasing calcium and phosphate levels by stimulating bone deposition and inhibiting calcium and phosphate reabsorption.

    Hormonal Interaction

    • Estrogen is important for maintaining bone health, stimulating bone deposition, bone growth, and sealing growth plates during puberty.
    • A decline in estrogen levels can lead to osteoporosis.

    Osteoporosis

    • Osteoporosis is characterized by a loss of mineral and organic matrix, leading to reduced bone density and an increased risk of fractures.
    • It is common in older adults, particularly post-menopausal women, due to declining estrogen levels.

    Energy from Food

    • Calories on a nutrition label represent the total energy in a food, regardless of its macronutrient source (fats, carbohydrates, proteins, etc.)
    • Percent daily values on nutrition labels are based on a 2000 calorie diet, but individual daily calorie requirements vary depending on metabolic rate

    Metabolic Rate

    • Metabolic rate is the rate at which the body expends energy per unit of time
    • It's measured by oxygen consumption and carbon dioxide production
    • Basal metabolic rate (BMR) is the metabolic rate under specific conditions: awake, comfortable temperature, 12-14 hours since eating, and relaxed
    • BMR varies depending on age, sex, body surface area, and thyroid hormone secretion
    • Physical activity, eating, and surrounding temperature are factors that influence metabolic rate

    Energy Balance and Weight

    • When energy input (caloric intake) exceeds energy expenditure, weight gain occurs
    • When energy input is less than energy expenditure, weight loss occurs
    • The body normally maintains a normal body weight range, with a set point, making it difficult to gain or lose weight
    • When trying to lose weight, a plateau may be reached due to the body's response to reduce appetite and increase metabolism

    Extreme Dieting and Weight Loss

    • A study on The Biggest Loser contestants found that 13 out of 14 regained weight, and 4 now weighed more than before the show
    • Extreme dieting may lower metabolic rate in the long term, making it harder to keep the weight off

    Eating Behavior Regulation

    • The hypothalamus is a key control center in the brain that regulates eating behavior
    • Hormones from various tissues (stomach, pancreas, small intestine, adipose tissue) influence the hypothalamus to regulate hunger and satiety
    • Hormones involved in eating behavior regulation include ghrelin, insulin, CCK, and leptin

    Hormones and Eating Behavior

    • Ghrelin stimulates hunger when released by the stomach when it's empty
    • Insulin suppresses hunger and promotes feelings of satiety when released by the pancreas after eating
    • CCK suppresses hunger and promotes feelings of satiety when released by the small intestine after a high-calorie meal
    • Leptin suppresses hunger and promotes feelings of satiety, and also influences metabolic rate, when released by adipose tissue

    Obesity and Hormones

    • A study on mice found that knocking out the leptin receptor or leptin gene led to constant hunger and weight gain due to overeating and slower metabolism
    • Leptin has implications for understanding obesity and its role in regulating metabolic rate and hunger

    Energy from Food

    • Calories on a nutrition label represent the total energy in a food, regardless of its macronutrient source (fats, carbohydrates, proteins, etc.)
    • Percent daily values on nutrition labels are based on a 2000 calorie diet, but individual daily calorie requirements vary depending on metabolic rate

    Metabolic Rate

    • Metabolic rate is the rate at which the body expends energy per unit of time
    • It's measured by oxygen consumption and carbon dioxide production
    • Basal metabolic rate (BMR) is the metabolic rate under specific conditions: awake, comfortable temperature, 12-14 hours since eating, and relaxed
    • BMR varies depending on age, sex, body surface area, and thyroid hormone secretion
    • Physical activity, eating, and surrounding temperature are factors that influence metabolic rate

    Energy Balance and Weight

    • When energy input (caloric intake) exceeds energy expenditure, weight gain occurs
    • When energy input is less than energy expenditure, weight loss occurs
    • The body normally maintains a normal body weight range, with a set point, making it difficult to gain or lose weight
    • When trying to lose weight, a plateau may be reached due to the body's response to reduce appetite and increase metabolism

    Extreme Dieting and Weight Loss

    • A study on The Biggest Loser contestants found that 13 out of 14 regained weight, and 4 now weighed more than before the show
    • Extreme dieting may lower metabolic rate in the long term, making it harder to keep the weight off

    Eating Behavior Regulation

    • The hypothalamus is a key control center in the brain that regulates eating behavior
    • Hormones from various tissues (stomach, pancreas, small intestine, adipose tissue) influence the hypothalamus to regulate hunger and satiety
    • Hormones involved in eating behavior regulation include ghrelin, insulin, CCK, and leptin

    Hormones and Eating Behavior

    • Ghrelin stimulates hunger when released by the stomach when it's empty
    • Insulin suppresses hunger and promotes feelings of satiety when released by the pancreas after eating
    • CCK suppresses hunger and promotes feelings of satiety when released by the small intestine after a high-calorie meal
    • Leptin suppresses hunger and promotes feelings of satiety, and also influences metabolic rate, when released by adipose tissue

    Obesity and Hormones

    • A study on mice found that knocking out the leptin receptor or leptin gene led to constant hunger and weight gain due to overeating and slower metabolism
    • Leptin has implications for understanding obesity and its role in regulating metabolic rate and hunger

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