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Questions and Answers

Which condition has the highest risk of osteoradionecrosis?

  • Traumatic procedures such as extractions (correct)
  • Smokers who have received no radiation
  • Radiation doses less than 65 Gy
  • Patients with good oral hygiene
  • What precaution should be taken to minimize complications after radiotherapy?

  • Use epinephrine during procedures
  • Perform extractions routinely
  • Implement hyperbaric oxygen therapy (correct)
  • Avoid prophylactic antibiotics
  • Which indicator suggests the need for tooth extraction in patients about to receive head and neck irradiation?

  • Presence of a non-painful tooth
  • Good overall dental health
  • Extensive mobility of a tooth (correct)
  • Pocket depths less than 3mm
  • In managing dental care for HIV patients, what is a crucial consideration?

    <p>Compromised immunity may need special attention</p> Signup and view all the answers

    Which factor is NOT a consideration when planning dental procedures for patients on chemotherapy?

    <p>Excessive tooth mobility</p> Signup and view all the answers

    What is the recommended period for a drug holiday before restarting Oral Bisphosphonates after treatment?

    <p>2 months</p> Signup and view all the answers

    What is a primary contributing factor to Osteoradionecrosis in the mandible compared to the maxilla?

    <p>More direct involvement of the mandible during radiation therapy</p> Signup and view all the answers

    Which of the following is NOT part of the recommended management following a surgical procedure in patients with Osteoradionecrosis?

    <p>Aggressive brushing</p> Signup and view all the answers

    What is the initial step in the case treatment sequence for managing Medication-Related Osteonecrosis of the Jaw (MRONJ)?

    <p>Antibiotics administration</p> Signup and view all the answers

    What is the purpose of Hyperbaric Oxygen (HBO) therapy in the management of Osteoradionecrosis?

    <p>To enhance healing of soft tissue necrosis</p> Signup and view all the answers

    What is the suggested platelet count threshold for transfusion prior to dental extraction?

    <p>50,000/mm3</p> Signup and view all the answers

    What is the minimum time frame recommended before initiating radiation therapy for dental extractions?

    <p>2 weeks</p> Signup and view all the answers

    In dental care for HIV patients, which of the following is a recommended precaution before a surgical procedure?

    <p>Administration of prophylactic antibiotics</p> Signup and view all the answers

    Which of the following symptoms is NOT associated with MRONJ?

    <p>Nausea and vomiting</p> Signup and view all the answers

    What oral health measure should be avoided in patients at risk for Osteoradionecrosis post-radiation therapy?

    <p>Aggressive brushing</p> Signup and view all the answers

    Which factor increases the risk of Osteoradionecrosis after radiation therapy?

    <p>Tobacco use post-therapy</p> Signup and view all the answers

    What is the AAOMS recommended drug holiday duration before and after dental procedures?

    <p>2 months before and 2 months after</p> Signup and view all the answers

    Which is the correct recommendation regarding packing agents during extraction in patients at risk for MRONJ?

    <p>Avoid gel foam due to infection risk</p> Signup and view all the answers

    Which of the following management strategies can help in the prevention of ONJ in at-risk patients?

    <p>Regular screening prior to drug therapy</p> Signup and view all the answers

    What is the defining feature of MRONJ?

    <p>Exposed bone in the maxillofacial region for more than 8 weeks</p> Signup and view all the answers

    Which radiographic finding is NOT characteristic of osteoradionecrosis?

    <p>Normal bone density</p> Signup and view all the answers

    Study Notes

    Evidence and Risk Considerations

    • Category X indicates existence of fetal abnormalities and risks in pregnancies; benefits do not justify use of certain medications.

    Oncologic Considerations

    • Primary goals in cancer treatment include reducing risks of infection and osteoradionecrosis (ORN).
    • Increased risk of ORN occurs in:
      • Patients with radiation to the posterior mandible
      • Those receiving >65 Gy radiation doses
      • Smokers
      • Patients with a history of traumatic dental procedures, such as extractions.

    Dental Management Post-Radiotherapy and Chemotherapy

    • Avoid epinephrine to prevent hypovascularity post-radiotherapy.
    • Hyperbaric oxygen (HBO) treatment and prophylactic antibiotics are recommended.
    • Extractions should be avoided during radiotherapy unless absolutely necessary.

    Tooth Extraction Guidelines

    • Extractions are indicated for severe dental issues such as:
      • Deep pockets (≥6mm), excessive mobility, or drainage of pus.
      • Broken, non-restorable, or poorly maintained teeth.
      • Associated inflammatory or infectious diseases.
    • Emergency situations warrant extraction regardless of conditions.

    Chemotherapy Considerations

    • Patients exhibit compromised immunity; risk increases over time (notably after 4 years).
    • Insufficient data exists to warrant stopping medications due to chemotherapy.
    • Oral Bisphosphonates (O.BPs) may require a drug holiday two months prior to surgery; medications not resumed until osseous healing is confirmed.

    Osteoradionecrosis (ORN)

    • Occurs following surgery or spontaneously in irradiated areas, characterized by non-healing exposed bone more than 6 months post-radiotherapy.
    • Predominantly observed in the posterior mandible due to reduced blood supply.

    Prevention and Management of ORN

    • Dental evaluations should occur at least two weeks before radiotherapy.
    • Extractions post-radiotherapy should be avoided, especially in the mandible.
    • Maintain optimal oral hygiene, utilize prophylactic antibiotics, and consider plain local anesthetics.
    • Hyperbaric oxygen may be beneficial pre- and post-operatively.
    • Limit extractions to minimal trauma – use saline irrigation and ensure no bony edges are left exposed.

    Guidelines for Postoperative Care

    • Employ gentle care with warm saline rinses, chlorhexidine mouthwash, and fluoride gel while avoiding tobacco.
    • Schedule follow-ups every three months for monitoring.

    AIDS and Extraction Guidelines

    • Patients with AIDS define severe immunosuppression; CD4+ count of less than 200 cells/uL necessitates caution.
    • Extraction precautions include:
      • Timing extractions two weeks prior to starting radiation or chemotherapy.
      • Avoiding sharp edges and ensuring primary closure post-extraction.
      • Monitoring platelet and white blood cell counts before procedures.
    • Defined by current or prior treatments with antiresorptive or antiangiogenic drugs.
    • Characterized by persistent exposed bone for over eight weeks without prior jaw radiation or metastatic disease.
    • Symptoms include pain, discomfort, tooth loss, and halitosis.

    Management and Prevention of MRONJ

    • Prevention strategies report up to a 50% decrease in jaw osteonecrosis when screening is utilized prior to therapy.
    • Cessation recommendations for medications vary; some guidelines suggest stopping two months prior to dental procedures, supported by limited evidence.

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