Module 1 - Important Info PDF

lOMoARcPSD|42413340 Module 1 - Important Info Physiology 1 (York University) Scan to open on Studocu Studocu is not sponsored or endorsed by any college or university Downloaded by Sandra Salama ([email protected]) ...

lOMoARcPSD|42413340 Module 1 - Important Info Physiology 1 (York University) Scan to open on Studocu Studocu is not sponsored or endorsed by any college or university Downloaded by Sandra Salama ([email protected])  lOMoARcPSD|42413340 All cells contain Nucleus Cytosol 3 PM Plasma Membrane lipid bilayer Selectively control movement of molecules Nucleus genetic Material directs protein Synthesis Smooth ER Packages Secretory Product into transport vesicles which then move to golgi Rough ER synthesizes proteins to be secreted or incorporated into PM Golgi Complex Modifies Packages 3 distributes newly synthesized proteins Lysosomes Break down organic molecules w Powerful hydrolytic enzymes Peroxisomes Oxidative Detoxify waste Products or foreign toxic compound Mitochondria Double membrane innerfoldings cristse inner cavity matrix Produces ATP contain enzyme for CTA s Etc Oxidative Phosphorylation Centrioles cylindrical Struc at right angles Form organize microtubies form Lilia s Flagella allow cells to move around part of cytoskeleton Vaults Carry cargo from nucleus to PM cytoskeleton Microtubles long hollow tubes made from tubulin largest cytoskel Protein highways for transport of secretory vesicles main Struc in flagella 3 Cilia assemble into mitotic spindle Microfilaments Smallest part of cytoskel helical chains of actin 3 myosin microfil Vital role in muscle contraction s amoeboid movement Change Shape Intermediate Filaments Irregular threadlike Proteins resists mechanical stress cytosol cell get Cellular Metabolism Intermediary Metabolism cytosol Chem runs that involve degradation synthesis 3 transformation of Small organic molecules Anabolic synth 3 Catabolic oles ATP contains high E phosphate bonds body's common currency has to be Produced Creatine Phosphate Substrate level Phosphorylation ATP in resting state ADP using LP 1stSource of E stored in cytoplasm LP contains high E bonds catalyzed by creatine kinase Downloaded by Sandra Salama ([email protected])  lOMoARcPSD|42413340 Respiration Glycolysis 10 Sequential runs break glue 6 c in 2 Pyruvates 3 c some E from bonds of glue r used to convert ADP into ATP occurs in cytosol Produces 2 ATP 3 2NADH Pyruvate Decarboxylation Removing L molecules enters mitochondrial matrix catalyzed in Acetyl cot 12 C eliminate I C molecule that gets exhaled Citric Acid Cycle TCA Krebs 8 Separatein mitochondrial matrix Z C r runs sequentially removed from G c citrate s converted back into 4C oxaloacetate s ready to accept new Acetyl CoA 2 r converted into coz the 2 Coz one from PD pass out to blood Oz comes from molecules involved in cycle not from breathing H atoms r removed which is a key Part NADt 3 FAD I ATP Produced 5 Processing of ACoA releases E GDP GTP 2 ACoA i 2 CAC spins Z ATP Produced 4 Atp in total Electron Transport Chain Most E is in H donates é easily occurs in inner mitochondrial membrane e extracted from NADH J FADHz e is Passed to Oz final e acceptor I exhaled Aka Oxidative Phosphorylation NADH s FADH leave H 3 go back to TCA AS e moves through release free E part of this E is used to transport Ht from matrix into intermembrane space at complexes I 3 Plasma Membrane Plasma Membrane Bilayer of lipid Seperates ECF 3 Ice controls movement of molecules in out of cell Structure Composition Phospholipids Polar hydrophilic head 3 2 nonPolar hydrophobic fatty acid chain tail Fluid Mosaic Model Mostly lipids fluidity 3 ever Changing membrane Mosaic Pattern many Proteins float freely Channels for 10.8mm water Soluble molecules Carrier molecules Docking Marker Acceptors Membrane bound enzymes Receptors for communication CAM Peripheral Proteins Cell to cell Adhesions Cell Adhesion Molecules CAM tissue cohesion like Velcro Extracellular Matrix Fibrous Proteins in a watery gel like substance composed of complex carbs Interstitial Fluid Pathway for diffusion of nutrients wastes 3 other water soluble traffic Collagen cable like fibres tensile strength 3 most abundant Protein 12 Protein by weight Downloaded by Sandra Salama ([email protected])  lOMoARcPSD|42413340 Elastin Rubber like stretching recoiling Fibronectin Promotes cell adhesion 3 holds cell in position reduced Y'Altitjtiontieriis instepithelial tissues abundant in Ct specialized cell Junctions Desmosomes Anchor 2 adjacent but non touching cells are where stretching occurs strongest connection Tight Junctions Stitched to 3 r impermeable bind tightly to found Primarily in sheets of epithelial tissue Gap Junctions exist btwn adjacent cells which r linked by Gaps connexons communicating Junctions Small watersoluble Abundant in cardiac 5 Smooth muscle Majority of Membrane Transport is on other Notes Tonicity effect Solin has on cell V determined by nonpenetrating solutes Osmolarity Measure of solute conc per unit V takes penetrating 3 non into account Pinocytosis non selective cell drinking Chacropinocytosis Receptor Mediated Endocytosis Selective uptake of large molecules Phagocytosis selective uptake of multimolecular particles cell eating Exocytosis No lysosome fusion Secretion of large Polar molecules addition of components of membrane Downloaded by Sandra Salama ([email protected])