Ocular Structures And Pharmacokinetics PDF
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Neisha M Rodriguez
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Summary
This document provides information on ocular structures and pharmacokinetics, including details about various structures within the eye (e.g., cornea, sclera), drug delivery methods, and the absorption of drugs by different eye tissues. It is intended for professional audiences like ophthalmologists.
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OCULAR STRUCTURES AND PHARMACOKINETICS Neisha M Rodriguez OD, MPH-G, PhD OBJECTIVES 01 LEARN OCULAR TISSUE STRUCTURES RELATED TO PHARMACOKINETICS CLASS BOOK OCULAR STRUCTURES AND PHARMACOKINETICS • PHARMACOKINETICS DRUG ABSORBTION DISTRIBUTION METABOLISM ELIMINATION • CAN BE DELIVERED 1....
OCULAR STRUCTURES AND PHARMACOKINETICS Neisha M Rodriguez OD, MPH-G, PhD OBJECTIVES 01 LEARN OCULAR TISSUE STRUCTURES RELATED TO PHARMACOKINETICS CLASS BOOK OCULAR STRUCTURES AND PHARMACOKINETICS • PHARMACOKINETICS DRUG ABSORBTION DISTRIBUTION METABOLISM ELIMINATION • CAN BE DELIVERED 1. LOCALLY – SOLUTIONS, OINTMENTS, EMULSIONS, INTRAVITRALLY ETC. 2. SYSTEMICALLY – ORALLY, INTRAVENOUSLY, INTRAMUSCULAR OCULAR STRUCTURES AND PHARMACOKINETICS TEAR FILM • THREE LAYERS LIPID AQUEOUS MUCUS • VOLUME 8 - 10 MICROLITERS • FLOW NORMAL (UNSTIMULATED) 0.5 - 22 mcl OCULAR STRUCTURES AND PHARMACOKINETICS CORNEA • EPITHELIUM TIGHT JUNCTIONS RESIST HYDROPHILIC DRUGS EX: FLUOROSCEIN • STROMA COLLAGEN FIBERS 90% CORNEAL THICKNESS HYDROPHILIC DRUGS • ENDOTHELIUM MONOLAYER MANTAIN OSMOSIS OCULAR STRUCTURES AND PHARMACOKINETICS SCLERA • OPAQUE VASCULAR STRUCTURE • CONJUNCTIVA – CONECTIVE TISSUE OVERLYING THE SCLERA • LIMITED ABSORBTION OF DRUGS SULFONAMIDES PROSTAGLANDINS OCULAR STRUCTURES AND PHARMACOKINETICS IRIS • REGULATES AMOUNT OF LIGHT • ADRENERGIC AND CHOLINERGIC INNERVATION • PIGMENT GRANULES - LIPOPHILIC DRUGS OCULAR STRUCTURES AND PHARMACOKINETICS AQUEOUS HUMOR • FORMED BY CILIARY BODY • EXIT TRBECULAR MESHWORK OR UVEOSCLERAL OUTFLOW OCULAR STRUCTURES AND PHARMACOKINETICS CILIARY BODY • PRODUCE AQUEOUS HUMOR • ACCOMODATION • SYSTEMIC DRUGS TO ANTERIOR CHAMBER • DRUG DETOX OCULAR STRUCTURES AND PHARMACOKINETICS C R Y S TA L L I N E L E N S • DOUBLE LAYER • GROW WITH AGE AND FLEXIBILITY IS REDUCED • RESISTANCE TO HYDROPHILIC DRUGS WITH HIGH MOLECULAR WEIGHT (CAPSULE) • LIPOPHILIC SLOWLY RATE (CORTEX) • BARRIER TO RAPID PENETRATING DRUGS • LENS REMOVAL (CATARACT SURGERY) OCULAR STRUCTURES AND PHARMACOKINETICS VITREOUS • VISCOELASTIC CONNECTIVE TISSUE • 80% OF THE OCULAR MASS • SOME MOLECULES CAN BE DIFUSSED • CAN BE A RESERVOIR FOR DRUGS OCULAR STRUCTURES AND PHARMACOKINETICS RETINA AND OPTIC NERVE • TIGHT JUNCTIONAL COMPLEX (ZONULA OCCLUDENTS) • CAPILLARIES DETERMINE MOLECULAR SELECTIVITY • BARRIER EFFECTIVE TOWARD HYDROPILIC DRUGS • LIPOPHILIC DRUGS CAN CROSS THE BARRIER
