Human Papillomavirus (HPV) Infection and Female Cervical Cancer PDF
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School of Medical and Health Sciences, Tung Wah College
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This document discusses human papillomavirus (HPV) infection and its connection to female cervical cancer. It covers the causes of the infection, the pathologic mechanisms involved, and the development/progression of the disease. The document also details signs, symptoms, and prevention strategies. It is a comprehensive overview of the topic.
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Human papillomavirus (HPV) infection Group 23 ...
Human papillomavirus (HPV) infection Group 23 CHENG Ka Wing 23002398 CHOI Ka Wai 24007086 HE Zuyuan 23007482 and female cervical cancer LEE Kai Yiu 23006962 NG Ki Lam 22003926 WONG Yat San 23007553 85% of people get an YEUNG Ho Yin 22007944 HPV infection introduction It is significantly contributes to the Human papillomavirus (HPV) infection is a development of cervical cancer in women. common sexually transmitted infection that is 20% develop to cervical cancer The 4th most common cancer in women spread through direct contact during sexual worldwide, activity. More than 200 Genotypes of HPV have ~660,000 new cases worldwide(2022) been discovered so far. 596 new confirmed cases in Hong Kong (2021) cause Micro-abrasions in the epithelial layer Pathologic mechanisms Cellular transformation: E6 and E7 oncoproteins Skin-to-skin sexual contact interact with essential cellular regulatory proteins, Multiple sex partners including p53 and pRb, resulting in the impairment of Initiating sexual activity too early cell cycle regulation and apoptosis. This alteration Weakened immune system facilitates the unrestrained proliferation of affected prolong infection cells. Development/progress of disease Progression to precancerous lesions: Persistent 1.HPV latent infection: 90% of HPV will be infection with high-risk types of HPV may result in Early stage of HPV infection. cleared by the immune the formation of precancerous lesions, including system within 1-2 years. HPV virus exists in the body. cervical intraepithelial neoplasia. After 5-10 years symptoms Viral integration: The viral DNA becomes incorporated or even longer into the genome of the host cell. This incorporation 2.HPV subclinical infection: interferes with the standard regulatory mechanisms The activity of the HPV virus of the cell cycle. begins to increase. Cervical precancerous Oncogene expression: The incorporation of HPV DNA columnar epithelium gradually lesion stage. can result in the production of viral oncoproteins, transforms into squamous specifically E6 and E7. These oncoproteins are epithelium. essential in facilitating cell growth and preventing programmed cell death. 3.Cervical lesion CIN1: 5.Cervical cancer: 4.Cervical lesions CIN2, CIN3: The primary stage of Changes in cervical cells more serious cervical cell intracervical disease. Mild have developed into cervical abnormalities. abnormal cells abnormal changes in cervical cancer. requires more increases cells. complex treatment. Change are more significant. Signs and symptoms symptom Treatment 1. Vaginal bleeding: Loop Electrosurgical premenopausal: intermenstrual bleeding Excision postmenopausal: always pathological Procedure (LEEP), 2. Vaginal discharge: Conization. (Wang & Palefsky, 2015) slight but continuous watery discharge: foul smell discharge 3. Advanced disease Progressive backache or pain prevention Urinary symptoms: from bladder irritation to hydronephrosis 1. Regular Screening: and vesico-vaginal fistula Pap smears Rectal symptoms: constipation; bleeding HPV Testing Metastatic symptoms: weight loss, nausea and vomiting 2. Encourage vaccination: HPV vaccines, Gardasil Cervarix. 3. Educate HPV transmission (Wang & Palefsky, 2015) References Bolhassani, A. (2018). HPV Infections: Diagnosis, Prevention and Treatment. Bentham Science Publishers Ltd. HPV infections: diagnosis, Prevention, and treatment. (2018). In BENTHAM SCIENCE PUBLISHERS eBooks. https://doi.org/10.2174/97816810861701180101 Luria, L., & Cardoza-Favarato, G. (2023, January 16). Human papillomavirus. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK448132/ World Health Organization. (2021). Cervical cancer. Retrieved from https://www.who.int/news-room/fact-sheets/detail/cervical-cancer Wang, C. J., & Palefsky, J. M. (2015). Human papillomavirus (HPV) infections and the importance of HPV vaccination. Current Epidemiology Reports, 2(2), 101–109. https://doi.org/10.1007/s40471-015-0039-3 Wang, M. Y., & Cun, Y. N. (2023). Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 57(10), 1647–1654. https://doi.org/10.3760/cma.j.cn112150-20221026-01037
