Proteins3-Myoglobin-lecture notes PDF
Document Details
Uploaded by Deleted User
Vanderwel
Tags
Summary
These lecture notes cover the fundamentals of myoglobin and haemoglobin. The notes outline the function of myoglobin in oxygen storage, and oxygen transport, including oxygen binding curves. The information is presented in a lecture format.
Full Transcript
Fundamentals of Biochemistry Fifth Edition Donald Voet Judith G. Voet Charlotte W. Pratt Chapter 7 Protein Function: Myoglobin and Hemoglobin MYOGLOBIN Unless ot...
Fundamentals of Biochemistry Fifth Edition Donald Voet Judith G. Voet Charlotte W. Pratt Chapter 7 Protein Function: Myoglobin and Hemoglobin MYOGLOBIN Unless otherwise indicated, all slides taken from Voet, Voet and Pratt, Fundamentals of Biochemistry, 4th Ed (2013) or 5th Ed (2016), with permission. 1 2 Oxygen transport and storage Myoglobin Or storage Hemoglobin O2 transport Myoglobin (Mb) 3 Iron- and oxygen-binding protein found in muscle tissue of vertebrates and almost all mammals Present at relatively high concentration (~2 mg/g) Thought to facilitate diffusion of O2 into cells In deep-diving mammals, [Mb] in muscles is ~10-30 x higher than terrestrial mammals Acts as O2 storage molecule Vanderwel, 2021 Oxygen Binding Curve for Myoglobin Henry’s Law: the solubility of a gas in a liquid is directly proportional to the pressure of that gas above the surface of the solution SI unit for pressure: Pascal 101325 Pa ≈ 1 bar ≈ 1 atm ≈ 760 torr ≈ 760 mm Hg Oxygen binding curve for Myoglobin PO2 (tissues) ~ 30 torr PO2 (venous) ~ 40-50 torr 5 PO2 (arterial) ~ 80-100 torr Flounder chicken beef ~0%
