PHA6133 Overview of Cosmetic Science Directive PDF

Unit I: Overview of Cosmetic Science based on ASEAN Cosmetic Directive OUTLINE Top 5 Mass Beauty Companies and Brands in the PH I. Introduction to Cosmetic Product Development...

Unit I: Overview of Cosmetic Science based on ASEAN Cosmetic Directive OUTLINE Top 5 Mass Beauty Companies and Brands in the PH I. Introduction to Cosmetic Product Development COMPANIES (SHARES % VALUE 2023) A. Market Overview B. Definition of Terms 1. Unilever Philippines Inc. II. ASEAN Cosmetic Directive (ACD) 2. Procter & Gamble Philippines Inc. A. Appendix I – Illustrative List of Cosmetic Head & Shoulders, Pantene, Olay, Oral-B Products by Categories 3. Avon Cosmetics Inc. B. Appendix III – ASEAN Cosmetic Claim 4. Johnson & Johnson (Philippines) Inc. Guideline Johnson’s, Aveeno, Listerine, Lubriderm C. Annexes of the ASEAN Cosmetic Directive 5. Splash Corp. III. Product Categorization in Different Markets SkinWhite, Vitress, Maxi-peel, Hygienix Market Overview BRANDS (SHARES % VALUE 2023) Mass Beauty and Personal Care Market 1. Safeguard (Procter & Gamble Co, The) Remains as the Top 1 Brand for many years Cosmetics that are affordable and used for basic 2. Cream Silk (Unilever Group) functions, such as cleansing (e.g., shampoo and soap) 3. Avon (Natura&Co - International Name) Retail value sales rise by 10% in current terms in 2023 4. Dove (Unilever Group) to ₱195 billion (2022 vs 2023 – there is an increase of 5. Johnson’s (Kenvue Inc. - International Name) purchasing power due to lesser pandemic restrictions) 6. Colgate and Palmolive (Colgate-Palmolive) Mass colour cosmetics or makeup is the best Dati nasa Top 5 siya, pero ngayon wala na performing category in 2023, with retail value sales *Examples were not stated, for supplementary purposes only rising by 25% in current terms to ₱18.2 billion Unilever Philippines Inc. is the leading player in 2023, Premium Beauty and Personal Care Market with a retail value share of 18% Cosmetics that are expensive – luxury lines. Aside from their main functions, they also have secondary claims ○ Use of exclusive, newly-discovered ingredients Retail value sales increase by 16% in current term in 2023 to ₱23.5 billion ○ This is due to the rise of promotions due to social media influencers and celebrities ○ Makes it more accessible, since young populations are more exposed to the brands ○ “Kaka-tiktok mo yan” ADDITIONAL INFORMATION Premium deodorants is the best performing category Remember that cosmetics is a highly competitive industry in 2023, with retail value sales growing by 29% in that checks trends, it is not formulated to treat diseases and is only used for cleansing, beautifying, or aesthetic purposes current terms to ₱865 million Estée Lauder Cos Inc. is the leading player in 2023, Thus, we refer to people as consumers instead of patients with a retail value share of 4% Retail sales are set to rise at a current value CAGR of 9% (2023 constant value CAGR of 6%) over the forecast period to ₱303 billion ○ Possibility of improvement in retail sales 6% if we account the inflation rate It is very important if we develop a cosmetic product based on the industry as a whole. Such as identifying which companies and brand products are leading. PAL, AAL | 1 PHA6133 LEC: OVERVIEW OF COSMETIC SCIENCE BASED ON ASEAN COSMETIC DIRECTIVE Retail sales are set to increase at a current value CAGR Scientific Areas Contributing to Cosmetic Science of 13% (2023 constant value CAGR of 10%) over the Anatomy and Since cosmetics are externally forecast period to ₱44.0 billion Physiology applied (topical; on the surface) ○ 10% if we account the inflation rate Ingredients should be stable Top 5 Premium Beauty Companies and Brands in the PH Chemistry enough when mixed together COMPANIES (SHARES % VALUE 2023) Should not produce degradants For secondary functions 1. Estée Lauder Cos Inc. 2. Elizabeth Arden Inc. ○ Main function: anti-aging 3. Shiseido Philippines Corp Pharmacology and antioxidant 4. L'Oréal Philippines Inc. ○ Secondary function: 5. Procter & Gamble Philippines Inc. skin-whitening Aside from the mass cosmetics market, it has a Manufacturing procedures line for premium cosmetics market as well Formulation ○ Research on suitable Technology product presentations BRANDS (SHARES % VALUE 2023) Always be updated 1. Elizabeth Arden (Revlon Inc. - International Name) Current Rules How to sell the product 2. Shiseido (Shiseido Co Ltd) and Regulations ○ Proper labeling and 3. Estèe Lauder packaging to avoid recall 4. SK-II (Procter & Gamble Co) 5. Chanel Analytical Sciences Will still undergo safety, quality, as 2023 Key Trends well as effectivity assessment Microbiology Skin Whitening Products Customer Needs Sun care products Main focus of cosmetic industries Marketing and ○ Sunscreen (Lotion, Stick, and Spray) Business Dermocosmetics brands ○ Increased products from Dra. Vicki Belo, Dr. Manny Calayan, and Dra. Aivee Teo Cosmetics Versus Drugs Celebrities and influencers Drugs Cosmetics Market Forecast Substance or preparation for Substance or preparation Increase in sales in beauty and personal care market human or veterinary use that intended to be placed in ○ Benefit sales of premium brands is intended to modify or contact with the external ○ Benefit from resumption of pre-pandemic explore physiological parts of the human body lifestyle systems or pathological (epidermis, hair system, Personal shopping services (online shopping makes states for the benefit of the nails, lips and external cosmetic products more accessible post-pandemic) recipient (WHO) genital organs) or with Continuous improvement the teeth and the mucous ○ Sun Care The intention is to membranes of the oral ○ Color Cosmetics cure or treat; there is cavity with a view exclusively ○ Men's Grooming change on the or mainly to cleansing them, physiological system perfuming them, changing Cosmetic Science their appearance, and/or correcting body odours ADDITIONAL INFORMATION and/or protecting or keeping Why is it important for us to know the market overview? them in good condition When we delve into cosmetic science, it is multidisciplinary. (ACD – Schedule B) Thus, we need to be knowledgeable in certain fields, such as: customer needs, marketing, and business. For a certain product to be considered as Because it focuses on customer needs and income rather a cosmetic, it should than treatment (since only a few ingredients are required) not be ingested or (talc + binder, may blush or eyeshadow ka na). Added have any other ROA expenses are only due to packaging and presentation. PAL, AAL | 2 PHA6133 LEC: OVERVIEW OF COSMETIC SCIENCE BASED ON ASEAN COSMETIC DIRECTIVE ONLY external use ADDITIONAL INFORMATION (such as Lactacid and What if the antidandruff shampoo was reviewed in the PH? Is pH care for external it considered a drug, cosmetic, or both a drug and cosmetic? genital organs) The antidandruff shampoo will be considered as a cosmetic Also take note of in the Philippines since we entertain secondary functions. their intended use Unlike in the USA, where cosmetics should be exclusive. Paano yung products with secondary-use? Go back to the definition of cosmetics, it should be MAINLY Cosmeceuticals used for cleansing, perfuming… etc. However there are still exceptions depending on the ingredients and claims used. Cosmetic Products Definition of Cosmetic Products Not legally recognized by ACD ○ Other countries call these as quasi drug Cosmetic products that have medicinal or drug-like benefits Why do we still include this? Because some cosmetic industries prefer to use the term “cosmeceuticals” Classified within a GRAY AREA: These have ingredients with drug-like effects but do not have enough concentration in order to be classified as a drug ○ 0.5% lang pero to be considered as a drug 10% There are 6 different markets ○ Drugs with vitamins, antioxidant, niacinamide ○ ACD is mostly patterned with Europe International Nomenclature ○ Meanwhile, in the USA, it should not have any secondary function (take note: EXCLUSIVELY) Cosmetic Ingredients (INCI) A certain product can fall into 2 If this is for cosmetics, the ones for drugs are New different categories: it can be a drug, or Chemical Entity (NCE), or Chemically Adopted Names a cosmetic. If the product is both a Systematic names internationally-recognized to identify drug and a cosmetic, it should follow its cosmetic ingredients corresponding guidelines. Published in the International Cosmetic Ingredient PIC/S for drugs Dictionary and Handbook (book of ingredients which ACD for cosmetics can be used for cosmetics, some even for drugs) Examples: ○ Glycerin, Butylated Hydroxytoluene (BHT - antioxidant), Alpha-arbutin, Glycerin (and) Aqua (and) Dipeptide diaminobutyroyl, benzylamide diacetate ASEAN Cosmetic Directive (ACD) Antidandruff ingredient - Selenium Additional examples for products that have both drug Category of Cosmetic Products and cosmetic functions include the following: Cosmetic Labeling Requirements ○ Toothpaste (anticavity, tooth decay prevention) Cosmetic Claim Guidelines ○ Deodorants (antiperspirant) Cosmetic GMP ○ Mouthwash (antibacterial) Cosmetic Ingredients ○ Facial foundation Cosmetic Product Notification ○ Facial cleanser (anti-acne) ○ Hand soaps (antibacterial) *Red is for Lecture, and those in black is for Laboratory PAL, AAL | 3 PHA6133 LEC: OVERVIEW OF COSMETIC SCIENCE BASED ON ASEAN COSMETIC DIRECTIVE Appendix I. Illustrative List of Cosmetic Products by Categories Since cosmetics are continuously innovative, this appendix just gives a short list of the categories of cosmetics. Take note that it is NOT EXHAUSTIVE. Categories Creams, emulsions, lotions, gels and oils for the skin (hands, face, feet, etc.) Face masks (with the exception of chemical peeling products - heavily exfoliating ingredients that may be classified as drugs already instead of cosmetics which should only be used when there is health professional) Tinted bases (liquids, pastes, powders) Make-up powders, after-bath powders, hygienic powders etc. Toilet soaps, deodorant soaps, etc. Perfumes, toilet waters and eau de Cologne Bath and shower preparations (salts, foams, oils, gels, etc.) Depilatories (for hair removal; e.g., Veet) Deodorants and antiperspirants Hair care products ○ Hair tints and bleaches, ○ Products for waving, straightening and fixing, ○ setting products, or cleansing products (lotions, powders, shampoos), ○ Conditioning products (lotions, creams, oils), ○ Hairdressing products (lotions, lacquers, brilliantines) Explanation Shaving products (creams, foams, lotions, etc.) Products for making-up and removing make-up from COMPOSITION the face and the eyes 1. Does the product contain only ingredients permitted Products intended for application to the lips by the ACD and no ingredients banned by the ACD? ○ Lipstick and Lipgloss Check the ingredient list (raw materials). Products for care of the teeth and the mouth Ingredients should be in the allowable list, ○ Mouthwash and Toothpaste there are ingredients that are banned for Products for nail care and make-up cosmetics but allowed in drug products. Products for external intimate hygiene TARGET SITE ○ Lactacid and pH care 2. Is the product intended for contact with the external Sunbathing products parts of the human body (epidermis, hair system, Products for tanning without sun nails, lips, and external genital organs) or with the Skin-whitening products teeth and the mucous membranes of the oral cavity? Anti-wrinkle products It should ALWAYS be externally applied. Sunstick Once the product is ingested, it is already ○ Externally applied and for protecting the skin – considered as a non-cosmetic product. not on the list but since it is nonexhaustive, this can be considered as a cosmetic product MAIN FUNCTION 3. Is the product intended exclusively or mainly to Appendix III. clean, perfume, change the appearance, and/or ASEAN Cosmetic Claim Guideline correct body odors and/or protext or keep the defined parts of the human body in good condition? This appendix serves as a guide whether a given If the product suggests “treatment of acne” product can be considered as a cosmetic or not which is to permanently remove it instead of If you want to market your product, in order for it to be only helping to reduce the acne, or considered as a cosmetic, this guideline is followed PAL, AAL | 4 PHA6133 LEC: OVERVIEW OF COSMETIC SCIENCE BASED ON ASEAN COSMETIC DIRECTIVE “skin-rejuvenating” meaning that it affects Completely prevents the skin cells, it is a non-cosmetic product. Deodorants & sweating/perspiration (“Helps you Antiperspirants stay dry for around 7 hours” is better) NON-COSMETIC PRESENTATION (Secondary Function) 4. Is the product presented as treating or preventing Perfumes or disease in human beings? Fragrances or Aphrodisiac or hormonal attraction Colognes NON-COSMETIC FUNCTION (Secondary Function) 5. Does the product permanently restore, correct, or Note that claims can be softened i.e. made less modify physiological function by exerting a functional and more cosmetic in nature by the use of pharmacological, immunological or metabolic action? modifiers. An example of this would be a claim for removing all oil from skin. This could be softened: Product Type Unacceptable Claims ○ Helps to remove oil from skin ○ Suitable for oily skin types Eliminates dandruff permanently ○ Reduces the shine of oily skin ○ You can claim that your ○ Makes your skin feel less oily product is anti-dandruff, but Hair Care only as dandruff reduction Products Restores hair cells Hair loss can be arrested or reversed REMEMBER Stimulates hair growth Using cosmetic claims is just a matter of words. Once products use “Treatment” and “Permanently,” that already denotes physiological change in the body. Thus, the Depilatories Stops/retards/prevents hair growth marketed product is considered as a non-cosmetic product. Reference to growth resulting from ANNEXES OF ASEAN COSMETIC DIRECTIVE (ACD) nourishment Annex II Part 1: Nail Products ○ It can be called as a ○ List of substances which must not form part of “nourishing product” but not the composition of cosmetic products in relation to growth itself ○ E.g., Theophylline (Methylxanthine) for asthma Prevents, reduces, or reverses the ANNEXES FOR REGULATED / RESTRICTED PRODUCTS physiological changes and Annex III Part 1: degeneration conditions brought ○ List of substances which cosmetics products about by aging must not contain except subject to Removes scars restrictions and conditions laid down Numbing effect Prevents, heals, treats or stops acne Annex III Part 2: Skin Products Treatment of cellulite (can be ○ List of substances provisionally allowed lightening of cellulite instead) ○ The product cannot be inhaled, but we can Lose centimeters utilize it (fragrance, spray-type cosmetics) Reduces/controls swelling/oedema Removes/burns fat Fungicidal action (use of API) ANNEXES FOR PERMITTED / ALLOWED PRODUCTS Virucidal action (use of API) Annex IV Part 1: ○ List of colouring agents allowed for use in Treatment or prevention of dental cosmetic products abscess, gumboils, inflammation, ○ Some colouring agents are not allowed due Oral or Dental mouth ulcers, periodontitis, to close contact with the eye, or prolonged Hygiene pyorrhoea, periodontal disease, contact with the skin which may cause skin Products stomatitis, thrush, or any oral irritation, dermatitis, and other skin problems diseases or infections Whitens tetracycline-induced stains Annex VI ○ List of preservatives allowed PAL, AAL | 5 PHA6133 LEC: OVERVIEW OF COSMETIC SCIENCE BASED ON ASEAN COSMETIC DIRECTIVE ○ There are some preservatives or Silver Nitrate antimicrobials that are used in drugs but not ○ Nagkukulay pag 7761-88-8 A1143 on cosmetic due to the nature of product natapon satin usage (Mas frequent and longer exposure ang cosmetic compared to a drug) N,N-diethyl-m-toluamide/Di 134-62-3, ○ E.g., Toothpaste ethyltoluamide (DEET) A1144 26545-51-7 ○ Insect repellant Annex VII ○ List of permitted UV filters which cosmetic N-5-Chloro 35783-57-4 1 products may contain. Benzoxazol-2-yl acetamide ○ E.g., Sunscreen 2-acetoxy ethyl 51-84-3/2260-5 trimethylammonium 0-6/927-866/6 2 hydroxide (acetylcholine) ANNEX II PART 1 6-23-9/60-31-1 and its salts List of substances which must not form part of the composition of cosmetic products Dimethyl sulfoxide (INN) (DMSO) Substances CAS No. Ref. No ○ Acts as a solvent Aminophylline or used for ○ Asthma treatment suspensions 317-34-0 A1136 ○ Good profile for 67-68-5 338 ○ Dose-related ADR (cardiotoxicity) skin permeation (nagiging Theophylline bioavailable since 58-55-9 A1137 it goes to the ○ Asthma treatment bloodstream) Methylene chloride (Dichloromethane) (DCM) Diphenhydramine (INN) ○ Used for lab and its salts experiments ○ Antihistamine 75-09-2 A1138 58-73-1/147-24- ○ Cold chemical, ○ Drowsiness 0/88637-37-0 339 carcinogenic, and (First generation) permeable to skin ○ Anticholinergic: and lung tissues dry mouth Chlorofluorocarbons (CFC) 4-tert-Butylphenol 98-54-4 340 ○ Degrades the - A1139 ozone layer 4-tert-butylpyrocatechol 98-29-3 341 Diethylene glycol (except if Dihydrotachysterol (INN) 67-96-9 342 it is present as 111-46-6 A1140 Dioxane unavoidable trace limit of 0.1% in finished product) ○ Carcinogenic ○ Common 123-91-1 343 Azelaic acid contaminant for ○ At certain cosmetic products concentration, it 123-99-99 1141 24556-64-7/87 will cure acne and Dibromo Salicylanilides -12-7/2577-72- 351 skin pigmentation 2 Bimatoprost Bithionol (INN) ○ Improves eyelash ○ Causes 97-18-7 352 growth 155206-00-1 A1142 photosensitivity ○ Glaucoma treatment Thiuram monosulphides 97-74-5 353 PAL, AAL | 6 PHA6133 LEC: OVERVIEW OF COSMETIC SCIENCE BASED ON ASEAN COSMETIC DIRECTIVE Column 4: Coloring agents allowed exclusively in cosmetic Additional information for ANNEX II PART 1 products intended to come into contact only briefly with the skin. These ingredients are already in the annex list because it is potent enough to be considered a drug HIGHLIGHTED BY MAAM Green (10006): can only be used if it is intended to We generally want to avoid ingredients with high come into contact only briefly with the skin permeability to skin since the cosmetics are not Red (12085): can be used for all cosmetic products, intended for anything other than topical applications but only at a maximum concentration of 3% ○ DCM and DMSO Orange (15510): can be used for all except eye-makeup products due to eye irritation Tandaan na pag ang primary function ng ingredient is pharmaceutical, it is not allowed in cosmetics. Pwede lang yung ingredients na may beneficial COSMETIC INGREDIENT REVIEW (CIR) secondary function BUT NOT beneficial primary The cosmetic ingredient review studies individual function (e.g., azelaic acid and bimatoprost). chemical compounds as they are used in cosmetic products. CIR relies heavily on the International ANNEX IV PART 1 Nomenclature of Cosmetic Ingredients (INCI) when List of Colouring Agents Allowed identifying the ingredients to be assessed. For Use in Cosmetic Products ○ Website where we can search for INCI names; can be used as a reference for the ingredients in our product development project ○ Safety precautions, profile, and function PRODUCT CATEGORIZATION IN DIFFERENT MARKETS EU Same in following the ACD guidelines Their soap can be categorized into 3 ○ Cleansing: Cosmetic ○ Anti-aging, Anti-whitening: Drug USA Anti-dandruff shampoo is already considered as both a drug AND a cosmetic since well-established na yung Colors can be red, yellow, but it all differs based on API niya in their manufacturing industries their color index number or denomination Field of application NHP: Natural Herbal Product (rosemary) Canada OTC: Synthetically-derived (niacinamide) Column 1: Colouring agents allowed in all cosmetic Classified based on ingredients used products Cosmeceuticals is not a legally Column 2: Colouring agents are allowed in all cosmetic recognized term, they make use of the products except those intended to be applied Japan term “quasi drug” instead in the vicinity of eyes, in particular eye make-up Anti-acne, anticaries, antiperspirant, hair and eye make-up remover. dye, anti-dandruff shampoo If antibacterial, anti-whitening, it is a Column 3: Colouring agents allowed exclusively in China non-cosmetic product already cosmetic products intended not to come into contact with the mucous membranes Brazil All are considered cosmetics PAL, AAL | 7  ANNEX III List of substances which cosmetic products must not contain except subject to restrictions and conditions laid down Ref No ACD # Substance/CAS No Restrictions Conditions of use and (EU #) warning which must be Field of application Maximum authorized Other limitations and printed on the labels and/or use concentration in the requirements ready for use preparation A B C D E F 2b Thioglycolic acid esters Hair waving or The directions for use drawn up in 1. Reducing agents straightening products: the national or official language(s) Contains thioglycolate Breaks disulfide must obligatorily incorporate the Follow the instructions bonds of hair 1. General use 1. 8% ready for following sentences: Keep out of reach of which makes it use at pH 6-9.5 May cause sensitization in children easier to reshape the event of skin contact. 2. Professional use 2. 11% ready for Avoid contact with eyes. 2. use at pH 6-9.5 In the event of contact with For professional use eyes, rinse immediately only with plenty of water and Contains thioglycolate Percentages calculated seek medical advice. Follow the instructions as thioglycolic acid Wear suitable gloves. Keep out of reach of children 31 Sodium fluoride (a) Oral hygiene 0.15% calculated as F. (a) & (b) products (except When mixed with other Contains sodium fluoride Sodium fluoride mouthwash) fluorine compounds CAS No. 7681-49-4 (b) Mouthwash permitted under this (a) Annex, total F “Children of 6 years and concentration must not younger: use a pea-sized exceed 0.15% (fluoride amount for supervised ALONE, not salt form) brushing to minimize swallowing. In case of intake of fluoride from other sources,  Too much fluoride consult a dentist or doctor.” (fluorosis) can cause enamel defects, (b) discoloration, white Do not use for children below spots thus the dose 6 years of age must be closely monitored for this. Children are prone to ingesting the toothpaste thus the dose should be monitored (Kaya pea size lang sila para at least pag nag mukbang sila ng toothpaste di delikado yung health nila.) 30 Calcium fluoride (a) Oral hygiene 0.15% calculated as F. (a) & (b) products (except When mixed with other Contains calcium fluoride Calcium fluoride mouthwash) fluorine compounds CAS No. 7789-75-5 (b) Mouthwash permitted under this (a) Annex, total F “Children of 6 years and concentration must not younger: use a pea-sized exceed 0.15% (fluoride amount for supervised ALONE, not salt form) brushing to minimize swallowing. In case of intake of fluoride from other sources, Too much fluoride consult a dentist or doctor.” (fluorosis) can cause enamel defects, (b) discoloration, white Do not use for children below spots thus the dose 6 years of age must be closely monitored for this. Children are prone to ingesting the toothpaste thus the dose should be monitored (Kaya pea size lang sila para at least pag nag mukbang sila ng toothpaste di delikado yung health nila.) 50 Aluminum zirconium Anti-perspirants 20% as anhydrous 1. The ratio of the number of Do not apply to irritated or chloride hydroxide aluminum aluminum atoms to that of damaged skin complexes zirconium chloride zirconium atoms must be AlxZr(OH)yClz and the hydroxide between 2 and 10 aluminum zirconium 5.4% as zirconium 2. The ratio of the number of chloride hydroxide Take note of the (Al + Zr) atoms to that of glycine complexes ratio since too chlorine atoms must be much AlZr(OH)Cl between 0.9 and 2.1 can cause 3. Prohibited in aerosol neurotoxicity (if dispensers (sprays) this is given through damaged or irritated skin) 49 Selenium sulfide Anti-dandruff shampoo 1% Contains selenium disulphide Selenium disulphide Avoid contact with CAS No. 7488-56-4 eyes or damaged skin 286 C16-alkyl trimethyl (a) Rinse-off hair products (a) 2.5% for the For purposes other than inhibiting ammonium chloride Mabilis lang individual the development of ginagamit concentrations or the microorganisms in the product. The C18-alkyl trimethyl (winawash agad) sum of the individual purpose has to be apparent from ammonium chloride concentrations of the presentation of the product. cetrimonium chloride Cetrimonium chloride and steartrimonium As a preservative, see Annex VI CAS No. 112-02-7 chloride Part 1, No 44. Steartrimonium (b) Leave-on hair products (b) 1.0% for the chloride Iniiwan sa buhok individual CAS No. 112-03-8 thus prolonged concentrations or the skin contact sum of the individual All of these are concentrations of preservatives cetrimonium chloride (antimicrobial agents) and steartrimonium chloride  (c) 0.5% for the (c) Face products individual Take note of the concentrations or the concentration sum of the individual and type. Pag concentrations of mas matagal cetrimonium chloride ginagamit, mas and steartrimonium mababa ang chloride concentration para less exposure. Toxicity may cause skin irritation and eye irritation, as well as development of allergic reactions.  ANNEX VI List of Preservatives which Cosmetic Products May Contain (may cause cardiotoxicity kaya konti lang siya) Reference Substance Maximum authorized Limitations and requirements Conditions of use and Number concentration warnings which must be printed on the label A B C D E 1 Benzoic acid (CAS No. 65-85-0), and its Rinse off products, except oral Take note of the sodium salt (CAS No. 532-32-1) care products; 2.5% (acid) concentration and type. Pag mas matagal Oral care products; 1.7% (acid) ginagamit, mas mababa ang concentration para Leave-on products; 0.5% (acid) less exposure. 25 5-Chloro-2-(2,4-dichlorophenoxy) phenol (a) 0.3% (a) Toothpastes, Hand soaps, Body (INCI) soaps/Shower gels, Deodorants Triclosan (INN) (non-spray), Face powders and blemish concealers, Nail products CAS No. 3380-34-5 for cleaning the fingernails and toenails before application of Very good preservative but due to artificial nail systems, Shampoo, this, it can also cause AMRs Hair conditioner, Facial cleanser (b) 0.2% (b) Mouthwashes  ANNEX VII List of UV Filters which Cosmetic Products May Contain (for sunscreen) Reference Substance Maximum authorized Limitations and requirements Conditions of use and Number concentration warnings which must be printed on the label A B C D E A28 Menthyl anthranilate 5% Used as fragrance or aromatic instead of a UV filter A29 Zinc oxide 25% Not to be used in applications that may lead to exposure of the CAS No. 1314-13-2 end-user’s lungs by inhalation (can cause difficulty in breathing) 27 Titanium dioxide 25% Titanium dioxide in powder form Usual UV filter used in sunscreens containing 1% or more of particles Under allowed ingredients, as with aerodynamic diameter ≤ 10 long as its size is ≤ 10 μm μm, to be used in compliance with Cause of white mask when using Annex III, No.. For the sunscreen due to particle size product types under letter (c) of column (c) in Annex III, No. , CAS No. 13463-67-7/1317-70-0/1317-80-2 the maximum concentration in ready for use preparation provided in column (c) of this entry applies 27a Titanium dioxide (nano) 25% Not to be used in applications that may lead to exposure of the CAS No. 13463-67-7/1317-70-0/1317-80-2) end-user’s lungs by inhalation Only nanomaterials having the following characteristics are allowed: - Purity ≥ 99% May specifications needed - Rutile form, or rutile with that’s why nanoparticle size is up to 5% anatase, with allowed for titanium dioxide. crystalline structure and Not all were discussed, briefly physical appearance as mentioned yung highlighted. clusters of spherical, needle, or lanceolate, - Median particle size based on number size distribution ≥ 30 nm, - Aspect ratio from 1 to 4.5 and volume specific surface area ≤ 460 m2/cm3 - Coating materials can be used that have been demonstrated to be safe and not to affect the nanoparticle properties related to the behavior and/or effects - Photocatalytic activity ≤ 10% compared with corresponding non-coated or non-doped reference, - Nanoparticles are photostable in the final formulation