Pathology Papers (1) PDF - February 2024 Past Paper

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- - - - - - = - - - - - - - - - - - - - - - - - = - - - - - I - E - - - - - = - - = E - - - - - - - - - - - - - - - - E E  All India Institute of Medical Sciences, Kalyani Second Professional MBBSExamination, February 2024 Time: 3 Hrs. Pathology (Paper—I) Marks: 100 (General Pathology, Hematopathology, Childhood diseases) Answer all questions. Answer the questions in the same serial order strictly. Illustrate your answers with well labelled diagram wherever necessary. Answer each section in a separate answer book. sECT10N - A (50MARKS) Long answer question: [1+2+3+4=101 2. A 28-yr-old female patient presented with easy fatigability and a red coloured butterfly - shaped rash in the face,which flaredup on sun exposure. She had a past bad obstetric history. Her preliminary evaluation demonstrated ANApositivity. a. What is the most probable diagnosis? b. What are the criteria for its diagnosis? c. What are the pathologicalchanges you see in the heart in this disease? d. Describe its pathogenesis. Write Short notes on: (8x5=401 -Z. Define paraneoplastic syndrome and give suitable examples. -Discuss the pathogenesis of septic shock. - Enumerate the differences between necrosis and apoptosis. Draw labelled diagrams depicting multistep evolution of colorectal carcinogenesis and briefly mention the roles of involved genes. -2. Enumerate pediatric small round cell tumors. Write a brief note on Neuroblastoma. -Diagnosis of amyloidosis -Klinefelter Syndrome -Pathogenesis of primary tuberculosis. Draw the microscopic findings in tubercular lymphadenitis.  SECTION - B (50MARKS) [2+4+4=101 Long answer question: with -8 years old girl presented with malaise and fatigue. On examination yellowish sclera hepatosplenomegalynoted. Familyhistory revealed similar complaints in her sibling also. Her hemoglobinlevel is 7.8g/dl. X-ray skull showed 'crewcut" appearance. a. What is your diagnosis? b. Write in detail about the pathogenesis and morphologicalfeatures of the disease. c. Enlist the various laboratory investigations required to confirm the diagnosis. Write Short notes on: Z. WHO classification - of acute myeloid leukemia -Rh incompatibility —-4< - Enumerate the causes of pancytopenia. Write the bone marrow findings of aplastic anemia. - -5. Enumerate causes of megaloblastic anemia. Briefly describe the pathogenesis megaloblastic anemia. --61 Disseminated intravascular coagulation - - diagnosis of multiple myeloma -F. Blood components and their uses and storage conditions - Chronic myeloid leukemia- Peripheral smear and Bone marrow findings.  All India Institute of Medical Sciences, Kalyani Second Professional MBBSExamination, February 2024 Time: 3 Hrs. Pathology (Paper—Il) Marks: 100 (Systemic Pathology) e Answer all questions. Answerthe questions in the same serial order strictly. Illustrate your answers with well labelled diagram wherever necessary. Answer each section in a separate answer book. Section A (50 Marks) [1+2+3+4=101 Long answer question: and cola coloured Z. A 18-yr-old female patient presented with fever, decreased urination back. urine. She had an episode of sore throat 2 months a. What is the most probable diagnosis? b. What are the urine examination findings in this case? disease? c. What are the pathological changes you see in the kidney in this d. Describe its pathogenesis. Write Short notes on: gross and microscopic morpholog r Z. Enumerate the osteogenic bone tumors. Describe the of osteosarcoma. features of HBV Enumerate the aeti010Uof chronic hepatitis and describe the microscopic hepatitis. X. Brieflydescribe the - aetio-pathogenesisof atherosclerosis.Draw a labelled diagram of an atheromatous plaque. d. MEN syndromes -.-8. Hydatidiform mole 7. Krukenberg tumor. X. Write about the pathogenesis and complications of Type 2 diabetes mellitus. Meningioma  Section B (50 Marks) Long answer question: [2+4+4=101 A 30-year-old female presented with a history of clyspareunia and post-coital bleeding. Per speculum examinationrevealedan unhealthy cervix which was irregular and bled on touch. 3. What is your probable diagnosis and why? Discuss the etiopathogenesisof the diagnosis. p. Discuss the screening methods for early detection of this condition Write Short notes on: 4. Describe the - etiopathogenesisof lobar pneumonia. Write its gross and microscopic features. Enumerate the differencesbetween Crohn's disease and Ulcerativecolitis. 8. What are metabolic liver diseases? Describe the pathogenesis of fatty liver disease. 3. Malignant melanoma- types and diagnosis. —6.Hashimoto thyroiditis a. Molecularclassification of breast cancers Enumerate the salivary gland neoplasms. Discuss the gross and microscopic findings in pleomorphicadenoma. Classifythe testicular tumors and describe the morph010U of seminoma.  DEPARTMENT OF PATHOLOGY & LAB MEDICINE A.I.I.M.S., KALYANI IVd Professional MBBS (4th Duration: 3 hrs Semester) Examination (Pathology) Total mark: 100 marks Answer all questions Thefigures in right hand margin indicate marks Mention the proper question number and sectionfor each answer. Draw diagram 's wherever necessary. SECTION - A (50 marks) - l) Define Acute Lymphoblastic Leukemia (ALL). Classify ALL as per FAB classification and WHO Classification. What are good and bad prognostic factors in ALL? Describe in short, the investigations of ALL. ( 1+3+2+4=10) 2) Short Notes: (5x8=40) - Peripheral blood smear and bone marrow findings of Megaloblastic Anaemia - Hodgkin Lymphoma c) Hereditary - spherocytosis- Pathogenesis and Morphological features. - Define Hypersplenism. List the causes of Splenomegaly - e) Etiopathogenesis of thrombotic microangiopathies f) Discuss laboratory approach for the diagnosis of Jaundice - Discuss the pathogenesis of Atherosclerosis. h) - Cardiac changes (morphology) in Rheumatic heart disease. SECTION- B (50 marks) 3) What are the differences between nephrotic and nephritic syndrome? Briefly write the pathogenesis of focal segmental glomerulosclerosis (FSGS). Write down the light microscopy, fluorescent and electron microscopy ofFSGS. (2+3+5=10) 4) Short Notes: (5x8=40) a) PAP smear is an important tool for screemng of cervical cancer- Discuss — Enumerate the germ cell tumours of Ovary. Describe the histological features of dysgerminoma with diagram. c) Non-invasive papillary tumours of urinary bladder d) Cystic diseases of the Kidney — Difference between complete and partial mole A f) Role of serum tumour markers in testicular tumours Discuss etiopathogenesis and pathology of emphysema. h) Summarise the differences between Phyllodes tumour & fibroadenoma of the — breast.  Department of Pathology All India Institute of Medical Sciences (AIIMS), Kalyani T€qruft, 741245 National Highway-34 Connector, Basantapur, Saguna, Kalyani, West Bengal 741245 PATHOLOGY Time 3 Hours MCQ : 10 Marks Theory : 90 Marks Total : 100 Marks YMCQ : Ix10 (I mark for correct answer and negative mark 0.25 for each incorrect answer) 1. For HBV infection, the term "healthy carrier" has been used for an individual with A. HBsAg and anti-HBe, without HBeAg B. Anti HBsAg and anti-HBe with HBeAg C. HBsAg and anti-HBe, with HBeAg D. Anti HBsAg with HBeAg yPatients with HemophiliaA have A. Prolonged APTT and a normal PT B. ProlongedAPIT and a prolonged PT C. Prolonged PT and normal APTT D. Normal PT and APTT Ill MPRSS6 gene mutation is associated with- A. Congenital sideroblastic anemia B. Iron resistant iron deficiency anemia C. Thalassemia D. Megaloblastic anemia IV chuller- Duval bodies are seen in- A. Dysgerminoma B. Choriocarcinoma C. Yolk sac tumour D. Teratoma YMalformations associated with predominantly Left- to- Right shunt except A. Atrial septal defect B. Ventricular septa! defect C. Patent ductus arteriosus D. Tetralogy of Fallot M¯WelI-established granulation tissue with new blood vessels and starting of collagen deposition occur in evolution of Myocardial Infarction at A. 1-3 days B. 3-7 days C. 7-10 days D.10-14 days YJzGenotype of -/- a /a with two normal alpha genes is seen in A. Hydrops fetalis B. HbH disease C. Alpha thalassemia trait D. Silent carrier of a thalassemia vKClara cells are seen in A. Alveoli B. Bronchus C. Trachea D. Bronchiole Udymphocytic infiltration and epithelial injury involving the small interlobular bile ducts with presence of poorly formed epithelioid cell granulomas is a morphological hallmark of -. A. Primary sclerosing cholangitis B. Primary biliary cholangitis C. Neonatal hepatitis D. Extrahepatic biliary atresia Koilocytes are most commonly seen in — A. HSIL B. LSIL C. Squamous cell carcinoma D. Candidiasis  oedema. (10) 2 patient presented with massive proteinuria, hypoalbuminemia and generalized V) What is your provisional diagnosis? (1) b What are the different causes? (2) seen in adults. Describe the types of pathogenesis and morphology of most common primary cause (64+3) Describe alcoholic liver disease under the following headings: (10) a)/ Pathogenesis of the disease. (3) Y ZMorphology of the disease. (3) Clinical features and complications. (2+2 = 4) 4. Write Short Notes: (5*10 =50) -Haemolytic Transfusion reaction: Types and Pathogenesis (2+3) Wilson Disease: Aetiology & Pathogenesis (2+3) c Comment on the role of exfoliative cytology on the screening of cervical cancer. -Differential diagnoses and approach to the diagnosis of microcytic hypochromic anaemia. (2+3) Write in brief about the adenoma-carcinomasequence in colorectal cancers. -Acute Promyelocytic Leukemia. Write about Gleason's grading of prostatic adenocarcinoma? h) Write a short note on Hydatidiformmole. - i) Etiopathogenesis and pathology of emphysema.(2+3) -Coal worker pneumoconiosis: types and pathogenesis (2+3) 5. Differences between the following: (4*5 = 20) Crohn's disease and Ulcerative colitis -ITP and TTP c) Mantle cell lymphoma and marginal zone lymphoma - d) Complete and partial hydatidiform mole -Chronic bronchitis and bronchial asthma. 4  DEPARTMENT OF PATJIO A.I.J.M.S., J IJ 'id Professional MBB.S (5th Semester I)uration: 3 hrs /fn.mer all Thefigure,} in rtght Separate sheet "Villbe pro Mention the proper quectcon num) Drcrø; diagram "g SECTION - A (50 marks) -. Describe thrombosis under following headings: 1 +3+2+4=101 a Define thrombosis. What are the causes of primary and secondary hypercoagulable states? rite in short about heparin induced thrombocytopenia. Describe morphology of different types of thrombi. 2. hort notes: - 15x5=251 - Pathogenesis of Septic shock. b Role of complement in inflammation. I Graft-Versus Host disease. - Viral Carcinogenesis. e) Neuroblastoma. - Brief answer: - [5x3=151 a - Enumerate the types of hypersensitivity reactions with one example each. - alanced reciprocal & Robertsonian translocation. - Acute phase reactants. - enal manifestation of SLE. - p53 mutation.  PATHOLOGY & LAB MEDICINE 1.1.M.S.,KALYANI Semester) Examination (Paper I - Pathology) Total mark: 100marks Answer all questions n right hand margin indicate marks t will be provided for section A & B. zestion number and section for each answer. iagram 's wherever necessary. SECTION - B (50 marks) -VA 2-year-old male child suffers from severe growth retardation prominent cheek bones and X-ray skull shows crew-cut appearance.Peripheral smear shows target cells and microcytes. +3+2+4=101 What is your provisional diagnosis? Describe the molecular pathogenesis of this disease. c) Classify the disease based on clinical features and genetic defects. Write in short the diagnostic approach of this disease. 5. Short notes: - [5x5=251 a - Peripheral smear and bone marrow findings of megaloblastic anemia. Pathogenesis and laboratory diagnosis of sickle cell anemia. / I WHO classification of Acute Myeloid Leukemia. d Pathogenesisof DIC z - - Laboratory diagnosis of Multiple Myeloma. 6. Brief answer: - [5x3=151 -Leucoerythroblastic blood picture. - Enumerate causes of eosinophilia. c) Mention storage conditions of - different blood components. -Transfusion transmitted infections. 4 -Burkitt's lymphoma.  A.J.J.M S Il Professional MBB.S (5th Semcqtcr) ration: 3 hrs 'Thefigures in '1%ht han Separate sheet will be pn Mention the proper question nun /)raw diagram "s SECTION - A (50 marks). A 12-yearold - boy had a history of sore throat. Now he has presented with fever, recurrentjoint pain and swelling of large joints. I-lehas pericardial friction rub and ECG abnormalities. 12+2+4+2=101 What is the most likely diagnosis? Explain with reasons. Outline the pathogenesis of the above condition. What are the morphological changes seen in heart? Enlist the long-term complications of the above condition. 2. Short tes: - 15x5=251 a) Describe the gross, light microscopic& electron microscopic changes in the - evolution of Myocardial infarction. [2+2+1=51 -Describe the classification & histopathology of Hodgkin lymphonpa. [1+4=5] Germ cell tumors of the ovary. X-ray, gross and histological findings of Osteoclastoma.-- [1+1+3=5] e) - Coal worker's pneumoconiosis. 3. Brief answer: - 15x3=151 Histomorphological features of Pleomorphic adenoma salivary gland. Barrett's Esophagus. Laboratory diagnosis of Wilson's disease. d Define - aneurysm and mention the four common clinical manifestations of abdominal aortic aneurysm. [1+231 e) Differentiate between Tubercular ulcer and Typhoid ulcer of small intestine.  LOGY & LAB MEDICINE KALYANI Examination (Paper Il - Pathology) Total mark: 1100 marks questions margin indicate marks videdfor section A & B. ber and section for each answer. herever necessary. SECTION B (50 marks) 4. -year-female in her first trimester of pregnancy presented with spontaneous eeding per vaginum with passage of occasional grape like vesicles with excessive vomiting. Her serum ß-HCG level was markedly elevated. 12+4+4=101 a What is your provisional diagnosis? Explain with reasons. Describe the cytogenetic abnormalities with diagram. c) abulate the differentiating features between the two morphological subtypes. 5. Short Notes: - 156=251 M dullary carcinoma of thyroid. Describe the light microscopy, immunofluorescence and electron microscopy features of Membranous nephropathy. [3+1+1=5] Endometrial Hyperplasia. d) Paget's disease of bone. Molecular classification of breast carcinoma. rief answer: - 150=151 Multiple endocrine neoplasm. Prostate Specific Antigen. - c Hypersplenism. / d pes of Melanoma. 4 Seminoma. - -