Introduction to Immunology GN PDF

Introduc)on to immunology Tutor: Ms P Lazarou Module: Biomedical Sciences 2 Student Learning guidelines The premise of this session is for you to complete the tasks in a self-directed way Work through each PowerPoint slide and follow the instructions There are links t...

Introduc)on to immunology Tutor: Ms P Lazarou Module: Biomedical Sciences 2 Student Learning guidelines The premise of this session is for you to complete the tasks in a self-directed way Work through each PowerPoint slide and follow the instructions There are links to documents and research articles which will enable you to gain knowledge of this subject and to complete the tasks as you proceed You are encouraged to use various methods of notetaking such as spider diagrams/pictures/tables to help you build up your Immunology notes It is important that you complete and have your notes in preparation for the next session in order that knowledge of the subject matter is consolidated. GDC Learning Outcomes The aim of this subject is to apply to the practice of dental therapy and dental hygiene principles that derive from the biomedical, behavioural and materials sciences. To develop knowledge in the study of immunology. GDC 1.1 Intended learning outcomes By the end of the session you will be able to: De#ne immunology and recognise the terminology associated with it Describe the natural defence systems of the body Iden8fy the components and func8ons of the non-speci#c (innate) and adap8ve (acquired) immune systems Di?eren8ate between non-speci#c (innate) and adap8ve (acquired) immunity Recognise and list the cells of the non-speci#c immune system and the adap8ve immune system Assessment Forma8ve Summa8ve Complete ‘Introduc8on to Biomedical Sciences Eassessment Immunology’ Workbook Student Learning Task 1 Download the following ar)cle from Moodle and read up to (10 of 14) ‘An)body-mediated vs. cell-mediated immunity’ An introduc)on to immunology and immunopathology Jean S. Marshall, Richard Warrington, Wade Watson and Harold L. Kim (2018) An introduc8on to immunology and immunopathology (biomedcentral.com) (15 minutes) Innate immunity - first immunological mechanism to intruding pathogen, initiated quickly, has no immunological memory. 4 defensive barriers; physiologic (temperature, pH, chemical mediators), anatomic (skin, mucous membrane), endocytic/phagocytic and inflammatory barriers. Relies on pattern recognition receptors (PRRs) -detect and respond rapidly to wide range of pathogens that share similar structure. Rapid recruitment of immune cells to sits of injection and inflammation. (Cytokines and chemokines) Phagocytes = neutrophils (short lived) and macrophages (long lived) = phagocytose microbes. Eosinophil Dendritic cells Mast cells Basophils T cells - lymphocytes Epithelial cells Cytokines Proteins and glycoproteins Adaptive immunity - development is aided by actions of innate immune system, antigen-dependent and antigen specific; capacity for memory. Enables host to mound a more rapid and efficient immune response but does involve a lag time. Recognise specific non self antigens and distinguish from self antigens. Cells - Antigen specific T cells, B cells which differentiate into plasma cells to produce antibodies. T cells & APC’s - derive from hamatopotetic stem cells in bone marrow. Express series of unique antigen binding receptors on membrane, T cell receptors. T cells require action of APCs to recognise specific antigens. Defects in either system can cause illness or disease. Immune system- collection of cells, chemical and processes that function to protect the skin, respiratory passages, intestinal tract and other areas from foreign antibodies. 2 lines of defence; innate and adaptive Student Learning Task 2 Research and make own notes/spider diagram/memory map on the organs and 2ssues of the Immune System in the Immunology Workbook (suggested resources): What are the organs of the immune system? - InformedHealth.org - NCBI Bookshelf (nih.gov) hDps://www.immunology.org/public-informaGon/bitesized-immunology hDps://www.healio.com/hematology-oncology/learn-immuno-oncology/the-immune-system/components-of-the-immune-system (15 minutes)  Within these organs, cells of immune system ‘fight Lymph nodes off’ foreign substances. Thymus Spleen Special immune system cells; Secondary organs lymphocytes Tonsils Primary organs Various mucous membranes Bone marrow S Components of immune system Student Learning Task 3 Notate and review terminology associated with immunology* Complete Worksheet 1 in the Immunology Workbook (20 minutes) Con